Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OA (ProHipQ-OA)
Osteoarthritis, Hip, Total Hip Arthroplasty, Prosthetic-joint Infection
About this trial
This is an interventional prevention trial for Osteoarthritis, Hip focused on measuring Antibiotic Prophylaxis, OA, Osteoarthritis, Osteoarthritis, Hip, Total Hip Replacement, Total Hip Arthroplasty, Prosthetic Joint Infection, PJI, Cluster Randomized Controlled Trial, Randomized Controlled Trial, RCT, THA
Eligibility Criteria
Inclusion Criteria:
1. All patients receiving a primary Total Hip Arthroplasty (THA) due to primary and secondary causes of osteoarthritis
Exclusion Criteria:
- Patients receiving a primary THA due to either acute or sequelae of proximal femoral or acetabular fractures
- Patients receiving a primary THA due to bone tumor or metastasis
Sites / Locations
- Department of Orthopedic Surgery, Hospital of Southern Jutland, Aabenraa and SønderborgRecruiting
- Capio Private Hospital, AalborgRecruiting
- Department of Orthopedic Surgery, Aalborg, Aalborg University HospitalRecruiting
- Capio Private Hospital, AarhusRecruiting
- Aleris Private Hospital, AarhusRecruiting
- Deaprtment of Orthopaedic Surgery, Aarhus University HospitalRecruiting
- Capio Private Hospital, GildhøjRecruiting
- Department of Orthopedic Surgery and Traumatology, Bispebjerg, Copenhagen University Hospital - Bispebjerg and FrederiksbergRecruiting
- Adeas Private Hospital, ParkenRecruiting
- Department of Orthopedic Surgery, Esbjerg, Hospital of South West JutlandRecruiting
- Department of Orthopedic Surgery, Farsø, Aalborg University HospitalRecruiting
- CPH Private HospitalRecruiting
- Department of Orthopedic Surgery, Frederikshavn, Aalborg University HospitalRecruiting
- Department of Orthopedic Surgery, Grindsted, Hospital of South West JutlandRecruiting
- Capio Private Hospital, Hellerup and OdenseRecruiting
- Department of Orthopaedic Surgery, Gentofte, Copenhagen University Hospital - Herlev and GentofteRecruiting
- Department of Orthopaedic Surgery, Herlev, Copenhagen University Hospital - Herlev and GentofteRecruiting
- Department of Orthopedic Surgery, Gødstrup Regional HospitalRecruiting
- Department of Orthopedic Surgery, Hillerød, Copenhagen University Hospital - North ZealandRecruiting
- Department of Orthopedic Surgery, Copenhagen University Hospital - HolbækRecruiting
- Department of Orthopedic Surgery, Horsens Regional Hospital, DenmarkRecruiting
- Department of Orthopedic Surgery, Hvidovre, Copenhagen University Hospital - Amager and HvidovreRecruiting
- Acure Private HospitalRecruiting
- Kollund Private Hospital, KollundRecruiting
- Department of Orthopedic Surgery, Zealand University Hospital, KøgeRecruiting
- Department of Orthopedic Surgery, Copenahegn University Hospital - Nykøbing FRecruiting
- Department for Planned Orthopaedic Surgery, Næstved, Copenhagen University Hospital - Næstved, Slagelse and RingstedRecruiting
- Department of Orthopedic Surgery and Traumatology, Odense University Hospital and Svendborg HospitalRecruiting
- Deparmtent of Orthopedic Surgery, Randers Regional HospitalRecruiting
- Aleris Private Hospital, RingstedRecruiting
- Department of Surgery, Copenhagen University Hospital - BornholmRecruiting
- Center for Planned Surgery, Silkeborg Regional HospitalRecruiting
- Aleris Private Hospital, SøborgRecruiting
- Department of Orthopedics, Lillebaelt Hospital, VejleRecruiting
- Mølholm Private Hospital, VejleRecruiting
- Deparmtent of Orthopedic Sugery, Viborg Regional HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Treatment A, Single-dose practice
Treatment B, Multiple-dose practice
One preoperative single dose of either Dicloxacillin/Cloxacillin 2g OR Cefuroxime 1.5g administered intravenously prior to surgical incision. As the study is a non-inferiority trial, we have chosen the Experimental design category.
One preoperative dose of either Dicloxacillin/Cloxacillin 2g OR Cefuroxime 1.5g administered intravenously prior to surgical incision followed by 3 postoperative doses of Dicloxacillin/Cloxacillin 1g x 3 OR Cefuroxime 750mg x 3 within 24 hours after the preoperative dose.