Efficacy of Chinese Traditional Medicine "Smart Soup" in Cognition and Behavior Regulation in Alzheimer's Disease
Alzheimer Disease, Mild Cognitive Impairment
About this trial
This is an interventional treatment trial for Alzheimer Disease focused on measuring Alzheimer's disease, Traditional Chinese Medicine, Smart soup
Eligibility Criteria
Inclusion Criteria:
- NIA-AA 2011 AD probable Alzheimer's disease, mild to moderate, stable use donepezil 10mg/d for 3 months
- NIA-AA 2011 AD probable Alzheimer's disease, severe, stable use donepezil 10mg/d and memantine 20mg/d for 3 months
- NIA-AA 2011 MCI probable criteria
- stable care giver
- Traditional Chinese medicine diagnosis: pixu tanzhuo
Exclusion Criteria:
- Severe systemic disease (heart, liver ,kidney function failure)
- contradictions of MRI examination
Sites / Locations
- Peking Union Medical College HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Sham Comparator
Active Comparator
Sham Comparator
Active Comparator
Sham Comparator
Group I severe AD
Group II severe AD
Group III Mild or moderate AD
Group IV Mild or moderate AD
Group V MCI
Group VI MCI
Patients over 40 years of age and eligible for NIA-AA 2011 probable severe AD will be given donepezil 10 mg, memantine 20 mg and smart soup
Patients over 40 years of age and eligible for NIA-AA 2011 probable severe AD will be given donepezil 10 mg, memantine 20 mg and placebo
Patients over 40 years of age and eligible for NIA-AA 2011 probable mild or moderate AD will be given donepezil 10 mg and smart soup
Patients over 40 years of age and eligible for NIA-AA 2011 probable mild or moderate AD will be given donepezil 10 mg and placebo
Patients over 40 years of age and eligible for NIA-AA 2011 probable MCI will be given smart soup
Patients over 40 years of age and eligible for NIA-AA 2011 probable MCI will be given placebo