Observation of the Comfort and Efficacy of CO2 Laser Combined With Cryo 6 for Burn or Linear Scars.
Cryotherapy Effect, Burn Scar, Scar; Previous Cesarean Section
About this trial
This is an interventional supportive care trial for Cryotherapy Effect
Eligibility Criteria
Inclusion Criteria:
- Age 14-60 years;
- The patient agreed to participate in the experiment and signed the informed consent by himself/herself or his/her legal representative;
- The clinical diagnosis was burn scar or post-operative linear scar, and the total area was more than 5 cm2.
- No other treatment such as laser or chemical exfoliation was performed on the lesion within the recent half year.
- Skin lesions were free of bleeding, ulceration, infection and other conditions affecting the visual field of laser treatment.
Exclusion Criteria:
- Patients with an active or established sun tan;
- Patients with history of allergic reaction to to topical anesthesia;
- Patients with history of keloid scarring, abnormal wound healing and/or prone to bruising;
- Skin malignant tumors or precancerous lesions;
- Patients with diabetes, heart disease, epilepsy, connective tissue disease, etc.;
- Pregnant or breastfeeding patients;
- Patients with recent skin infections (such as viral and bacterial infections);
- Patients who are using other methods to treat similar diseases;
- Patients who had taken isotretinoin within the past year;
- History of cryoglobulinaemia;
- History of cold agglutinin disease and cold haemolysis;
- History of cold urticaria;
- Parts of the body with impaired circulation;
- Raynaud's disease;
- Parts of the body with impaired sensitivity;
- Trophic disorders;
- Hypersensitivity to cold;
- Patients with mental illness;
- Other ineligible patients.
Sites / Locations
- Xinhua Hospital affiliated to Shanghai Jiaotong University School of MedicineRecruiting
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
Control group: CO2 fractional laser alone
Combination group: CO2 fractional laser combined with Cryo 6
This group of patients is the treatment control group. During the treatment period, the cold-air cooling device Cryo 6 will be placed next to the laser equipment but not started. The air outlet position is about 3 to 7 centimeters away from the skin, and it will move slowly and synchronously according to the laser position. The skin temperature will be synchronously monitored and recorded by hand-held infrared thermometry. After the operation, the investigators use hospital's routine aftercare procedures, and continue to use hand-held infrared thermometry to synchronously monitor the skin temperature.
During the CO2 fractional laser treatment, cool the skin with cold-air cooling device Cryo 6. Set the wind to level 5, and the maximum time to 30 minutes. The air outlet position is about 3 to 7 centimeters away from the skin, and it will move slowly and synchronously according to the laser position. The skin temperature will be synchronously monitored by hand-held infrared thermometry and maintained at 0°C to 5°C. After the operation, the investigators use hospital's routine aftercare procedures and cooling with Cryo 6 on the skin synchronously. The wind level can be selected by patients themselves from level 3 to 7, and the time can be set for 5 minutes. Put the air outlet about 3 to 7 centimeters away from the skin, and move it slowly and dynamically in this area of skin to monitor and record the skin temperature synchronously.