Adjunctive Duration-doubled tDCS for the Treatment of Depressive Patients With Suicidal Ideation
Suicidal Ideation
About this trial
This is an interventional treatment trial for Suicidal Ideation
Eligibility Criteria
Inclusion Criteria:
- Ages are from 18 to 50;
- Meeting the criteria of the Diagnostic and Statistical Manual of Mental Disorder (DSM-5) for current unipolar MDD, which is assessed by at least one professional psychiatrist;
- Han ethnicity;
- Right handedness;
- With a score≥17 on the HAMD-1713;
- With a score≥6 on the BSI14;
- Without any pharmacotherapy at baseline or maintaining actual pharmacotherapy for at least 2 weeks before the stimulation initiation and during the total stimulation period.
Exclusion Criteria:
- Assessed through applying the Mini-International Neuropsychiatric Interview (MINI)15 by professional psychiatrists that diagnosed any other current or past psychiatric axis-I disorders (except MDD in the patients);
- Severe liver and kidney diseases, active endocrine diseases or clinical symptoms. Severe cardiovascular disease, respiratory system disease, haematologic diseases and cancer;
- Any clinically significant abnormal laboratory examination that may influence the health of participants;
- A history of any aignificant medical illness such as neurological disorders (such as cerebral trauma, seizure disorder, etc);
- Known current psychosis as determined by the DSM-5 or a history of a non-mood psychotic disorder;
- Current alcohol and drug abuse;
- Pregnancy or lactation;
- Abnormal scalp such as open wounds;
- HAMD-17 item 3 (suicide) score=4;
- Receiving modified electroconvulsive therapy (MECT) or repetitive transcranial magnetic stimulation (rTMS) in the past 1 month;
- Participation in another clinical trial concurrently or no more than 1 month prior to randomisation.
Sites / Locations
- Shanghai Mental Health CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
active tDCS
sham tDCS
tDCS devices (Neuroelectrics, Starstim 8, USA) are used. The anode and cathode electrodes are inserted in saline-soaked sponges with diameter of 3.2cm and then positioned over the left and right dorsolateral prefrontal cortex (DLPFC) using specific headgear. Each session uses a 2mA current and lasts 60 minutes. Ten sessions are daily performed.
The anode and cathode electrodes are inserted in saline-soaked sponges with diameter of 3.2cm and then positioned over the left and right dorsolateral prefrontal cortex (DLPFC) using specific headgear. Each session uses a 2mA current and lasts 60 minutes. Ten sessions are daily performed. For sham, the current rapidly ramp up to 2mA over the first 30s and rapidly ramped down to 0mA over the next 30s automatically to allow participants to feel typical initial sensations of active tDCS.