Micro-UltraSound In Cancer - Active Surveillance (MUSIC-AS)
Prostate Cancer
About this trial
This is an interventional diagnostic trial for Prostate Cancer focused on measuring Active surveillance, micro-ultrasound
Eligibility Criteria
Inclusion Criteria:
- Adult men with Gleason Grade Group 1 prostate cancer managed by active surveillance who require a confirmatory prostate biopsy
Exclusion Criteria:
- Men who cannot undergo a prostate MRI
- Men who cannot undergo a prostate biopsy
Sites / Locations
- Kipnes Urology Centre - Kaye Edmonton ClinicRecruiting
Arms of the Study
Arm 1
Experimental
Combined MRI and micro-ultrasound guided prostate biopsy.
In a single biopsy session, first, a microUS-guided biopsy of regions of interest (ROIs) will be performed. The MRI fusion software will then be turned on, the clinician unblinded to the MRI results, and biopsy cores from within the boundaries of the MRI-fused lesion will be sampled from ROIs. Up to two ROIs identified on microUS or MRI will be targeted with up to 3 cores per ROI. If the MRI ROIs overlap with the microUS ROIs after unblinding, then the cores taken during the microUS-guided biopsy will be counted as both microUS and MRI-guided. Finally, a standard 12-core systematic biopsy will be performed.