Intrathecal Dexamethasone and Atropine on Morphine Induced Post-operative Nausea and Vomiting on Caesarean Section
Morphine Adverse Reaction
About this trial
This is an interventional prevention trial for Morphine Adverse Reaction
Eligibility Criteria
Inclusion Criteria:
- Female
- 18-45 years old
- ASA: 1, 2
- Elective caesarean section under spinal anaesthesia.
Exclusion Criteria:
- Patient refusal.
- Contraindications to spinal anaesthesia as coagulopathy, infection at site of injection, hemodynamic instability and uncooperative patient.
- Contraindications to administration of morphine as asthmatic patient and hypersensitivity and contraindications to any of the study drugs.
- Adult-Emergency CS as there is no time for preparation and risk on fetus and mother for time consuming
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Other
Other
Dexamethasone group (D)
Atropine group (A)
Dexamethasone and Atropine group (DA)
Patients will receive intrathecal hyperbaric bupivacaine 0.5% in a dose of 12.5 mg (2.5 ml) mixed with morphine in a dose of 200 µg (0.5 ml was withdrawn from a syringe containing 4 mg morphine sulfate diluted in 10 ml normal saline) [Total volume 4 ml], followed by intrathecal dexamethasone 4 mg (1ml).
Patients will receive intrathecal hyperbaric bupivacaine 12.5 mg (2.5 ml 0.5%) mixed with morphine 200 µg (0.5 ml) and atropine100 µg (0.5 ml was withdrawn from a syringe containing 2 mg atropine sulfate diluted in 10 ml normal saline) [Total volume 3.5 ml].
Patients will receive intrathecal hyperbaric bupivacaine in a dose of 12.5 mg (2.5 ml) mixed with morphine 200 µg (0.5 ml) and atropine 100 µg (0.5 ml), followed by intrathecal injection of dexamethasone 4 mg (1 ml) [Total volume 4.5 ml] .