PROFAST Intervention in Precursor Multiple Myeloma (PROFAST)
Cancer Prevention, Weight Loss, Smoldering Waldenstrom Macroglobulinemia(WM)
About this trial
This is an interventional prevention trial for Cancer Prevention focused on measuring Cancer prevention, Weight loss, Smoldering Waldenstrom Macroglobulinemia(WM), MGUS, Smoldering Multiple Myeloma, Prolonged nightly fasting, Multiple Myeloma
Eligibility Criteria
Inclusion Criteria:
- BMI >= 25 kg/m2
- Documented diagnosis of MGUS or Smoldering MM(SMM) or Smoldering Waldenstrom Macroglobulinemia(WM) via EMR review. *note: please review case with PI or treating MD if diagnosis is uncertain.
- At least 18 years of age
- Currently fasting for <14 hours per night, as assessed using 24-hour food recalls
- Owns a cell phone and is comfortable sending and receiving text messages
- Ability to understand and the willingness to sign a written informed consent document
Exclusion Criteria:
- Diagnosis of overt MM or WM
- Patients diagnosed with another malignancy requiring active therapy
- Clinical diagnosis of diabetes, which may increase the risk of hypoglycemia with a prolonged fast. Note: patients with diabetes may enroll with consent from MD that manages their clinical care.
- Any other condition that, in the investigator's judgment, would contraindicate prolonged nightly fasting or otherwise interfere with participation in the trial, including night shift work, night eating syndrome, taking weight loss medication, or participation in another weight loss program
Sites / Locations
- Dana Farber Cancer InstituteRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
PROLONGED FASTING INTERVENTION
EDUCATION CONTROL
The prolonged nightly fasting (PROFAST) intervention involves gradually working up to a 14-hour fast during the nighttime hours. Participants will be supported by means of calls with a health coach during the first 4 weeks of the study. Participants will also be asked to use a text messaging platform to record their first and last meal of the day, and will receive personalized feedback based on the meal times they record via the text messaging system. The text messaging system will be used throughout the duration of the study.
For participants randomized to the control group, an introductory session with a health coach and educational information will be provided. Participants will also receive one email and one text message per week with tips on healthy living during the 4 months of the study