Oxidative Stress, Carbohydrate Metabolism Disorders and G6PD Deficiency
G6PD Deficiency, Carbohydrate Metabolism Disorder, Oxidative Stress
About this trial
This is an interventional treatment trial for G6PD Deficiency
Eligibility Criteria
Inclusion Criteria:
- Individuals with normal G6PD activity
- Individuals with G6PD deficiency
- Individuals with CHO metabolism disorders (diabetes, prediabetes)
- Individuals with G6PD deficiency and CHO metabolism disorders (diabetes, prediabetes)
Exclusion Criteria:
- Health problems that contraindicate participation to exercise
- Should not take any medication that affects the body's antioxidant mechanisms as well as dietary supplements containing antioxidants
- Women during lactation or gestation
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
G6PD deficiency (only) - Intervention
G6PD deficiency (only) - Placebo
G6PD deficiency and CHO metabolism disorder - Intervention
G6PD deficiency and CHO metabolism disorder - Placebo
CHO metabolism disorder (only) - Intervention
CHO metabolism disorder (only) - Placebo
Controls - Intervention
Controls - Placebo
Alpha-lipoic acid supplementation (600 mg/day) for 4 weeks in a counterbalanced manner to 10 G6PD deficient individuals.
Placebo administration for 4 weeks in a counterbalanced manner to 120 G6PD deficient individuals.
Alpha-lipoic acid supplementation (600 mg/day) for 4 weeks in a counterbalanced manner to 10 individuals with G6PD deficiency and a CHO metabolism disorder.
Placebo for 4 weeks in a counterbalanced manner to 10 individuals with G6PD deficiency and a CHO metabolism disorder.
Alpha-lipoic acid supplementation (600 mg/day) for 4 weeks in a counterbalanced manner to 10 individuals with a CHO metabolism disorder.
Placebo for 4 weeks in a counterbalanced manner to 10 individuals with a CHO metabolism disorder.
Alpha-lipoic acid supplementation (600 mg/day) for 4 weeks in a counterbalanced manner to 10 individuals without G6PD deficiency and/or any CHO metabolism disorder.
Placebo for 4 weeks in a counterbalanced manner to 10 individuals without G6PD deficiency and/or any CHO metabolism disorder.