Different Catheter Ablation Strategy in Vasovagal Syncope
Syncope, Vasovagal
About this trial
This is an interventional prevention trial for Syncope, Vasovagal focused on measuring Vasovagal syncope, cardioneuroablation
Eligibility Criteria
Inclusion Criteria:
- Sign the informed consent form.
- Definitely diagnosed as vasovagal syncope (according to the 2018 ESC syncope diagnosis and management guidelines).
- Positive head-up tilt test (cardiac inhibition type, vascular inhibition type, mixed type).
- Syncope attacks ≥ 3 times in 1 year before operation and / or recurrence of syncope in the last 6 months.
- More than 2 kinds of routine treatment were ineffective or could not tolerate their side effects.
Exclusion Criteria:
- Syncope caused by other causes.
- Heart failure (NYHA grade Ⅲ or IV), congenital heart disease, valvular heart disease, deficiency. Bloody heart disease, hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic cardiomyopathy and myocarditis, chronic. Hepatic and renal insufficiency, diabetes, nervous system diseases, etc.
- Acute coronary syndrome or myocardial infarction occurred in recent 6 months; cerebrovascular events occurred in recent 3 months (such as short. Transient ischemic attack, stroke) or other disturbance of cerebral blood supply.
- Previously undergone cardiac catheter ablation, cardiac surgery and / or permanent cardiac pacemaker implantation.
- Left atrial thrombus and / or left atrial diameter > 55mm or EF < 35% were found by echocardiography or CT.
- Pregnancy and lactation.
Sites / Locations
- China National Center for Cardiovascular DiseasesRecruiting
- Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Ablation of left atrial ganglion plexus
combined ablation of left and right atrial ganglion plexus
In this arm, ablation of GPs will only performed in the left atrium, including ablation of right anterior ganglion plexus (RAGP),left superior ganglion plexus (LSGP),left ganglion plexus (LLGP), left interior ganglion plexus (LIGP) and right interior ganglion plexus(RIGP).
In the arm the, ablation of GPs will perform in both atrium, including ablation of right anterior ganglion plexus (RAGP),left superior ganglion plexus (LSGP),left ganglion plexus (LLGP), left interior ganglion plexus (LIGP), right interior ganglion plexus (RIGP), and superior vena cava ganglion plexus (SVCGP). SVCGP were ablated in the right atrium,the left GPs were ablated through the left atrium