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ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study) (ACTION)

Primary Purpose

H3 K27M, Glioma

Status
Recruiting
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
ONC201
ONC201 + Placebo
Placebo
Sponsored by
Chimerix
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for H3 K27M focused on measuring H3 K27M, H3 K28M, H3 K27-altered, histone, H3F3A, HIST1H3B, HIST1H3C, H3.1, H3.3, DMG, thalamus, thalamic, midline

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Able to understand the study procedures and agree to participate in the study by providing written informed consent (by participant or legally authorized representative), and assent when applicable.
  2. Body weight ≥ 10 kg at time of randomization.
  3. Histologically diagnosed H3 K27M-mutant diffuse glioma (new diagnosis). Detection of a missense K27M mutation in any histone H3-encoding gene detected by testing of tumor tissue (immunohistochemistry [IHC] or next-generation sequencing [NGS] in a Clinical Laboratory Improvement Amendments [CLIA]-certified or equivalent laboratory). [Site to provide (as available): ≥ 10 unstained formalin-fixed paraffin-embedded (FFPE) slides from tumor tissue.]
  4. At least one, high-quality, contrast-enhanced MRI of the brain obtained prior to starting radiotherapy for submission to sponsor's imaging vendor for central read. For participants who had a surgical resection, this scan must be post-resection; for participants who did not have a resection, this scan may be pre- or post-biopsy.
  5. At least one, high-quality, contrast-enhanced MRI of the brain obtained 2 to 6 weeks after completion of frontline radiotherapy. [Site to also provide all available MRIs completed prior to initiating treatment with study intervention.]
  6. Completed standard frontline radiotherapy within 2 to 6 weeks prior to randomization. Standard frontline radiotherapy is defined as a dose of 54 to 60 Gy at 1.8 to 2.2 Gy/fraction. Radiotherapy must be initiated within 12 weeks from initial diagnosis of H3 K27M-mutant diffuse glioma and within 8 weeks of most recent surgical resection/biopsy.
  7. Karnofsky Performance Status or Lansky Performance Status ≥ 70 at time of randomization.
  8. Stable or decreasing dose of corticosteroids and anti-seizure medications for 7 days prior to randomization, if applicable. Stable steroid dose is defined as ≤ 2 mg/day increase (based on dexamethasone dose or equivalent dose of an alternative steroid).

Exclusion Criteria:

  1. Primary spinal tumor.
  2. Diffuse intrinsic pontine glioma (DIPG), defined as tumors with a pontine epicenter and diffuse involvement of the pons.
  3. Evidence of leptomeningeal spread of disease or cerebrospinal fluid dissemination.
  4. Any known concurrent malignancy.
  5. New lesion(s) outside of the radiation field.
  6. Received whole-brain radiotherapy.
  7. Received proton therapy for glioma.

  8. Use of any of the following treatments within the specified time periods prior to randomization:

    1. ONC201 or ONC206 at any time.
    2. Bevacizumab (includes biosimilars) at any time.
    3. Temozolomide within past 3 weeks.
    4. Tumor treating fields at any time.
    5. DRD2 antagonist within past 2 weeks.
    6. Any investigational therapy within past 4 weeks.
    7. Strong CYP3A4/5 inhibitors within 3 days.
    8. Strong CYP3A4/5 inducers (includes enzyme-inducing antiepileptic drugs) within 2 weeks.

  9. Laboratory test results meeting any of the following parameters within 2 weeks prior to randomization:

    1. Absolute neutrophil count < 1.0 × 109/L or platelets < 75 × 109/L.
    2. Total bilirubin > 1.5 × upper limit of normal (ULN) (participants with Gilbert's syndrome may be included with total bilirubin > 1.5 × ULN if direct bilirubin is ≤ 1.5 × ULN).
    3. Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 2.5 × ULN.
    4. Creatinine clearance ≤ 60 mL/min as calculated by the Cockcroft Gault equation (or estimated glomerular filtration rate < 60 mL/min/1.73 m2).
  10. QTc > 480 msec (based on mean from triplicate electrocardiograms) during screening.
  11. Known hypersensitivity to any excipients used in the study intervention formulation.
  12. Pregnant, breastfeeding, or planning to become pregnant while receiving study intervention or within 3 months after the last dose. Participants of childbearing potential must have a negative serum pregnancy test within 72 hours prior to receiving the first dose of study intervention.
  13. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection requiring systemic therapy or psychiatric illness/social situations that would limit compliance with study requirements.
  14. Any other condition (eg, medical, psychiatric, or social) that, in the opinion of the investigator, may interfere with participant safety or the ability to complete the study according to the protocol.

Sites / Locations

  • Barrow Neurological InstituteRecruiting
  • Banner MD Anderson Cancer CenterRecruiting
  • Phoenix Childrens HospitalRecruiting
  • University of California IrvineRecruiting
  • UC San Diego Moores Cancer CenterRecruiting
  • UCLA University of California Los AngelesRecruiting
  • Children's Hospital of Orange CountyRecruiting
  • Providence Saint John's Cancer InstituteRecruiting
  • Stanford Cancer CenterRecruiting
  • Yale UniversityRecruiting
  • MedStar Georgetown University HospitalRecruiting
  • Miami Cancer InstituteRecruiting
  • St Joseph's Children's Hospital of TampaRecruiting
  • Moffitt Cancer CenterRecruiting
  • Indiana University School of Medicine - IndianapolisRecruiting
  • University of Iowa Hospitals & ClinicsRecruiting
  • The Stephen E. and Catherine Pappas Center for Neuro-OncologyRecruiting
  • Dana Farber Cancer InstituteRecruiting
  • University of Michigan HospitalRecruiting
  • Washington University School of MedicineRecruiting
  • Benefis Hospital Sletten Cancer InstituteRecruiting
  • University of Nebraska Medical CenterRecruiting
  • Overlook Medical CenterRecruiting
  • Albany Medical CenterRecruiting
  • Children's Hospital at Montefiore Medical CenterRecruiting
  • Montefiore Medical ParkRecruiting
  • Columbia University Medical CenterRecruiting
  • Levine Cancer Institute/ Atrium HealthRecruiting
  • Duke Cancer InstituteRecruiting
  • Cincinnati Children's Hospital Medical CenterRecruiting
  • Cleveland ClinicRecruiting
  • Ohio Statue UniversityRecruiting
  • University of Oklahoma Peggy and Charles Stephenson Cancer CenterRecruiting
  • Providence Health and Services St. Vincent Medical CenterRecruiting
  • University of PennsylvaniaRecruiting
  • Thomas Jefferson UniversityRecruiting
  • UPMC Hillman Cancer CenterRecruiting
  • Neuro-Oncology AssociatesRecruiting
  • University of Texas Southwestern Medical CenterRecruiting
  • University of Texas MD Anderson Cancer CenterRecruiting
  • UT Health Science Center Houston Department of NeurosurgeryRecruiting
  • University of Utah - Huntsman Cancer InstituteRecruiting
  • Inova Schar Cancer InstituteRecruiting
  • Children's Hospital of The King's DaughterRecruiting
  • University of WashingtonRecruiting
  • University Of Wisconsin - MadisonRecruiting
  • Sydney Children's HospitalRecruiting
  • Royal North Shore HospitalRecruiting
  • Royal Hobart HospitalRecruiting
  • Olivia Newton-John Cancer Research Institute (ONJCRI)Recruiting
  • BC Cancer - The Vancouver CenterRecruiting
  • Sunnybrook Health Sciences CentreRecruiting
  • Princess Margaret HospitalRecruiting
  • Copenhagen University HospitalRecruiting
  • Aalborg UniversitetshospitalRecruiting
  • Odense UniversitetshospitalRecruiting
  • Universitätsklinikum HeidelbergRecruiting
  • Universitätsklinikum AugsburgRecruiting
  • University Clinic RegensburgRecruiting
  • Klinikum der Johann-Wolfgang Goethe-UniversitatRecruiting
  • Universitätsklinikum BonnRecruiting
  • Universitätsklinikum EssenRecruiting
  • Uniklinik KölnRecruiting
  • Vivantes Klinikum NeuköllnRecruiting
  • Klinikum Mannheim Universitätsklinikum gGmbHRecruiting
  • Universitätsklinikum TübingenRecruiting
  • Sheba Medical CenterRecruiting
  • Soroka University Medical CentreRecruiting
  • Rambam Medical CenterRecruiting
  • Hadassah Ein Kerem Medical CenterRecruiting
  • Schneider Children's Medical Center of IsraelRecruiting
  • Rabin Medical CenterRecruiting
  • Tel Aviv Sourasky Medical CenterRecruiting
  • Ospedale BellariaRecruiting
  • Istituto Nazionale Tumori Regina ElenaRecruiting
  • Ospedale San Raffaele S.r.l.Recruiting
  • Fondazione IRCCS Di Rilievo Nazionale Istituto Nazionale Neurologico Carlo BestaRecruiting
  • Istituto Clinico HumanitasRecruiting
  • Azienda Ospedaliera Città della Salute e della Scienza di TorinoRecruiting
  • Istituto Oncologico VenetoRecruiting
  • CHA Bundang Medical CenterRecruiting
  • National Cancer CenterRecruiting
  • Samsung Medical CenterRecruiting
  • Gangnam Severance Hospital, Yonsei University Health SystemRecruiting
  • Seoul National University HospitalRecruiting
  • Severance Hospital Yonsei University Health SystemRecruiting
  • The Catholic University of Korea, Seoul St. Mary's HospitalRecruiting
  • Erasmus MCRecruiting
  • Universitair Medisch Centrum Utrecht Cancer CenterRecruiting
  • Hospital Sant Joan de DeuRecruiting
  • Clinica Universidad NavarraRecruiting
  • Hospital Clinic de BarcelonaRecruiting
  • Hospital Universitario Vall d'HebronRecruiting
  • Hospital Infantil Universitario Niño JesusRecruiting
  • Hospital Universitario 12 de OctubreRecruiting
  • Hospital Universitario HM SanchinarroRecruiting
  • Hospital Universitari i Politecnic La Fe de ValenciaRecruiting
  • Hospital Universitari i Politecnic La Fe de ValenciaRecruiting
  • Centre Hospitalier Universitaire VaudoisRecruiting
  • Universitätsspital ZürichRecruiting
  • Addenbrooke's HospitalRecruiting
  • Beatson West of Scotland Cancer CentreRecruiting
  • Royal Hospital for Children (Glasgow)Recruiting
  • Clatterbridge Cancer Centre - LiverpoolRecruiting
  • The Christie NHS Foundation TrustRecruiting
  • The Royal Marsden in Sutton, SurreyRecruiting
  • Royal Victoria InfirmaryRecruiting
  • Freeman HospitalRecruiting
  • St James University HospitalRecruiting
  • The Leeds Teaching Hospitals NHS Trust, Leeds General InfimaryRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Placebo Comparator

Arm Label

ONC201 Twice Weekly Group

ONC201 Once Weekly Group

Placebo Group

Arm Description

Outcomes

Primary Outcome Measures

Overall survival (OS)
Overall Survival is defined as the time from randomization to death due to any cause.
Progression free survival (PFS) as assessed by using RANO-HGG criteria
PFS is defined as time from randomization to disease progression (PD) or death.

Secondary Outcome Measures

Incidence of adverse events
Incidence of overall, treatment-related, Grade 3 or higher in severity, serious, fatal, those resulting in treatment discontinuation, and events of special interest
Change from baseline in clinical laboratory parameters
Percentage of participants with clinically significant laboratory results
PFS using RANO-HGG criteria
PFS using RANO-HGG criteria for participants with measurable contrast-enhancing disease
Corticosteroid response
Corticosteroid response will be measured by a confirmed 50% decrease in use of dexamethasone or equivalent
Performance status response
Performance status response will be measured by confirmed increase in Karnofsky Performance Status (KPS) or Lansky Performance Status (LPS)

Full Information

First Posted
September 27, 2022
Last Updated
October 16, 2023
Sponsor
Chimerix
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1. Study Identification

Unique Protocol Identification Number
NCT05580562
Brief Title
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
Acronym
ACTION
Official Title
ONC201 for the Treatment of Newly Diagnosed H3 K27M-mutant Diffuse Glioma Following Completion of Radiotherapy: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study
Study Type
Interventional

2. Study Status

Record Verification Date
October 2023
Overall Recruitment Status
Recruiting
Study Start Date
January 23, 2023 (Actual)
Primary Completion Date
August 2026 (Anticipated)
Study Completion Date
August 2026 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Chimerix

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
This is a randomized, double-blind, placebo-controlled, parallel-group, international, Phase 3 study in patients with newly diagnosed H3 K27M-mutant diffuse glioma to assess whether treatment with ONC201 following frontline radiotherapy will extend overall survival and progression-free survival in this population. Eligible participants will have histologically diagnosed H3 K27M-mutant diffuse glioma and have completed standard frontline radiotherapy.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
H3 K27M, Glioma
Keywords
H3 K27M, H3 K28M, H3 K27-altered, histone, H3F3A, HIST1H3B, HIST1H3C, H3.1, H3.3, DMG, thalamus, thalamic, midline

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigator
Allocation
Randomized
Enrollment
450 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
ONC201 Twice Weekly Group
Arm Type
Experimental
Arm Title
ONC201 Once Weekly Group
Arm Type
Experimental
Arm Title
Placebo Group
Arm Type
Placebo Comparator
Intervention Type
Drug
Intervention Name(s)
ONC201
Intervention Description
Participants ≥ 52.5 kg will receive 625 mg of ONC201 (5 × 125-mg capsules) dosing days; participants < 52.5 kg will receive a dose (and corresponding number of capsules) scaled by body weight and rounded to 125-mg increments.
Intervention Type
Drug
Intervention Name(s)
ONC201 + Placebo
Intervention Description
Participants ≥ 52.5 kg will receive 625 mg of ONC201 (5 × 125-mg capsules) or matching placebo on dosing days; participants < 52.5 kg will receive a dose (and corresponding number of capsules) scaled by body weight and rounded to 125-mg increments
Intervention Type
Other
Intervention Name(s)
Placebo
Intervention Description
Participants will receive placebo (same number of capsules as the ONC201 dose) on dosing days
Primary Outcome Measure Information:
Title
Overall survival (OS)
Description
Overall Survival is defined as the time from randomization to death due to any cause.
Time Frame
From date of randomization until date of death from any cause, assessed up to approximately 44 months
Title
Progression free survival (PFS) as assessed by using RANO-HGG criteria
Description
PFS is defined as time from randomization to disease progression (PD) or death.
Time Frame
From date of randomization until the date of first documented progression assessed up to approximately 44 months
Secondary Outcome Measure Information:
Title
Incidence of adverse events
Description
Incidence of overall, treatment-related, Grade 3 or higher in severity, serious, fatal, those resulting in treatment discontinuation, and events of special interest
Time Frame
From date of randomization up to 44 months
Title
Change from baseline in clinical laboratory parameters
Description
Percentage of participants with clinically significant laboratory results
Time Frame
From date of randomization up to 44 months
Title
PFS using RANO-HGG criteria
Description
PFS using RANO-HGG criteria for participants with measurable contrast-enhancing disease
Time Frame
From date of randomization up to 44 months
Title
Corticosteroid response
Description
Corticosteroid response will be measured by a confirmed 50% decrease in use of dexamethasone or equivalent
Time Frame
From date of randomization up to 44 months
Title
Performance status response
Description
Performance status response will be measured by confirmed increase in Karnofsky Performance Status (KPS) or Lansky Performance Status (LPS)
Time Frame
From date of randomization up to 44 months

10. Eligibility

Sex
All
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Able to understand the study procedures and agree to participate in the study by providing written informed consent (by participant or legally authorized representative), and assent when applicable. Body weight ≥ 10 kg at time of randomization. Histologically diagnosed H3 K27M-mutant diffuse glioma (new diagnosis). Detection of a missense K27M mutation in any histone H3-encoding gene detected by testing of tumor tissue (immunohistochemistry [IHC] or next-generation sequencing [NGS] in a Clinical Laboratory Improvement Amendments [CLIA]-certified or equivalent laboratory). [Site to provide (as available): ≥ 10 unstained formalin-fixed paraffin-embedded (FFPE) slides from tumor tissue.] At least one, high-quality, contrast-enhanced MRI of the brain obtained prior to starting radiotherapy for submission to sponsor's imaging vendor for central read. For participants who had a surgical resection, this scan must be post-resection; for participants who did not have a resection, this scan may be pre- or post-biopsy. At least one, high-quality, contrast-enhanced MRI of the brain obtained 2 to 6 weeks after completion of frontline radiotherapy. [Site to also provide all available MRIs completed prior to initiating treatment with study intervention.] Completed standard frontline radiotherapy within 2 to 6 weeks prior to randomization. Standard frontline radiotherapy is defined as a dose of 54 to 60 Gy at 1.8 to 2.2 Gy/fraction. Radiotherapy must be initiated within 12 weeks from initial diagnosis of H3 K27M-mutant diffuse glioma and within 8 weeks of most recent surgical resection/biopsy. Karnofsky Performance Status or Lansky Performance Status ≥ 70 at time of randomization. Stable or decreasing dose of corticosteroids and anti-seizure medications for 7 days prior to randomization, if applicable. Stable steroid dose is defined as ≤ 2 mg/day increase (based on dexamethasone dose or equivalent dose of an alternative steroid). Exclusion Criteria: Primary spinal tumor. Diffuse intrinsic pontine glioma (DIPG), defined as tumors with a pontine epicenter and diffuse involvement of the pons. Evidence of leptomeningeal spread of disease or cerebrospinal fluid dissemination. Any known concurrent malignancy. New lesion(s) outside of the radiation field. Received whole-brain radiotherapy. Received proton therapy for glioma. Use of any of the following treatments within the specified time periods prior to randomization: ONC201 or ONC206 at any time. Bevacizumab (includes biosimilars) at any time. Temozolomide within past 3 weeks. Tumor treating fields at any time. DRD2 antagonist within past 2 weeks. Any investigational therapy within past 4 weeks. Strong CYP3A4/5 inhibitors within 3 days. Strong CYP3A4/5 inducers (includes enzyme-inducing antiepileptic drugs) within 2 weeks. Laboratory test results meeting any of the following parameters within 2 weeks prior to randomization: Absolute neutrophil count < 1.0 × 109/L or platelets < 75 × 109/L. Total bilirubin > 1.5 × upper limit of normal (ULN) (participants with Gilbert's syndrome may be included with total bilirubin > 1.5 × ULN if direct bilirubin is ≤ 1.5 × ULN). Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 2.5 × ULN. Creatinine clearance ≤ 60 mL/min as calculated by the Cockcroft Gault equation (or estimated glomerular filtration rate < 60 mL/min/1.73 m2). QTc > 480 msec (based on mean from triplicate electrocardiograms) during screening. Known hypersensitivity to any excipients used in the study intervention formulation. Pregnant, breastfeeding, or planning to become pregnant while receiving study intervention or within 3 months after the last dose. Participants of childbearing potential must have a negative serum pregnancy test within 72 hours prior to receiving the first dose of study intervention. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection requiring systemic therapy or psychiatric illness/social situations that would limit compliance with study requirements. Any other condition (eg, medical, psychiatric, or social) that, in the opinion of the investigator, may interfere with participant safety or the ability to complete the study according to the protocol.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Tarapore, PhD
Phone
1-919-806-1074
Email
clinicaltrials@chimerix.com
Facility Information:
Facility Name
Barrow Neurological Institute
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
085013
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Robert Yoo, DO
Phone
602-406-8605
Email
research@ivybraintumorcenter.org
First Name & Middle Initial & Last Name & Degree
Robert Yoo, DO
Facility Name
Banner MD Anderson Cancer Center
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85006
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Na Tosha Gatson
First Name & Middle Initial & Last Name & Degree
Na Tosha Gatson
Facility Name
Phoenix Childrens Hospital
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85016
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lindsey Hoffmann, DO
Email
lhoffman1@phoenixchildrens.com
First Name & Middle Initial & Last Name & Degree
Lindsey Hoffmann, DO
Facility Name
University of California Irvine
City
Costa Mesa
State/Province
California
ZIP/Postal Code
92628
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiao-Tang Kong, MD, PhD
Email
xkong@hs.uci.edu
First Name & Middle Initial & Last Name & Degree
Xiao-Tang Kong, MD, PhD
Facility Name
UC San Diego Moores Cancer Center
City
La Jolla
State/Province
California
ZIP/Postal Code
92093
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jessica Schulte, MD
Email
jdschulte@health.ucsd.edu
First Name & Middle Initial & Last Name & Degree
Jessica Schulte, MD
Facility Name
UCLA University of California Los Angeles
City
Los Angeles
State/Province
California
ZIP/Postal Code
90095
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Phioanh Nghiemphu, MD
Email
PNghiemphu@mednet.ucla.edu
First Name & Middle Initial & Last Name & Degree
Phioanh Nghiemphu, MD
Facility Name
Children's Hospital of Orange County
City
Orange
State/Province
California
ZIP/Postal Code
92868
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mariko Sato, MD, PhD
Email
Mariko.Sato@choc.org
First Name & Middle Initial & Last Name & Degree
Mariko Sato, MD, PhD
Facility Name
Providence Saint John's Cancer Institute
City
Santa Monica
State/Province
California
ZIP/Postal Code
90404
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Akanksha Sharma, MD
Email
neuro.research@providence.org
First Name & Middle Initial & Last Name & Degree
Akanksha Sharma, MD
Facility Name
Stanford Cancer Center
City
Stanford
State/Province
California
ZIP/Postal Code
94350
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kate Therkelsen, MD
Email
ktherk@stanford.edu
First Name & Middle Initial & Last Name & Degree
Kate Therkelsen, MD
Facility Name
Yale University
City
Fairfield
State/Province
Connecticut
ZIP/Postal Code
06824
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicholas Blondin, MD
Email
nblondin@anscneuro.com
First Name & Middle Initial & Last Name & Degree
Nicholas Blondin, MD
Facility Name
MedStar Georgetown University Hospital
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20007
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Edina Komlodi-Pasztor, MD, PhD
Email
Edina.Komlodi-Pasztor@medstar.net
First Name & Middle Initial & Last Name & Degree
Edina Komlodi-Pasztor, MD, PhD
Facility Name
Miami Cancer Institute
City
Miami
State/Province
Florida
ZIP/Postal Code
33176
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yazmin Odia, MD
Phone
786-596-2000
Email
YazminO@BaptistHealth.net
First Name & Middle Initial & Last Name & Degree
Paul R Ferguson
Email
Paul.Ferguson@baptisthealth.net
First Name & Middle Initial & Last Name & Degree
Yazmin Odia, MD
Facility Name
St Joseph's Children's Hospital of Tampa
City
Tampa
State/Province
Florida
ZIP/Postal Code
33607
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Trisha Larkin, MD
Email
trisha.larkin@baycare.org
First Name & Middle Initial & Last Name & Degree
Trisha Larkin, MD
Facility Name
Moffitt Cancer Center
City
Tampa
State/Province
Florida
ZIP/Postal Code
33612
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Vogelbaum, MD
Email
michael.vogelbaum@moffitt.org
First Name & Middle Initial & Last Name & Degree
Michael Vogelbaum, MD
Facility Name
Indiana University School of Medicine - Indianapolis
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Daniel Runco, MD
Email
drunco@iupui.edu
First Name & Middle Initial & Last Name & Degree
Daniel Runco, MD
Facility Name
University of Iowa Hospitals & Clinics
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Dickens, MD
Email
david-dickens@uiowa.edu
First Name & Middle Initial & Last Name & Degree
David Dickens, MD
Facility Name
The Stephen E. and Catherine Pappas Center for Neuro-Oncology
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Isabel Arrillaga-Romany, MD
Email
iarrillaga@mgh.harvard.edu
First Name & Middle Initial & Last Name & Degree
Isabel Arrillaga-Romany, MD
Facility Name
Dana Farber Cancer Institute
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Patrick Wen, MD
Email
pwen@partners.org
First Name & Middle Initial & Last Name & Degree
Patrick Wen, MD
Facility Name
University of Michigan Hospital
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carl Koschmann, MD
Email
ckoschma@med.umich.edu
First Name & Middle Initial & Last Name & Degree
Carl Koschmann, MD
Facility Name
Washington University School of Medicine
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andrew Cluster, MD
Email
acluster@wustl.edu
First Name & Middle Initial & Last Name & Degree
Andrew Cluster, MD
Facility Name
Benefis Hospital Sletten Cancer Institute
City
Great Falls
State/Province
Montana
ZIP/Postal Code
59405
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Matthew Smith-Cohn, DO
Email
MatthewSmith-Cohn@Benefis.org
First Name & Middle Initial & Last Name & Degree
Matthew Smith-Coh, DO
Facility Name
University of Nebraska Medical Center
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68114
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chittalsinh Raulji, MD
Email
craulji@childrensomaha.org
First Name & Middle Initial & Last Name & Degree
Chittalsinh Raulji, MD
Facility Name
Overlook Medical Center
City
Summit
State/Province
New Jersey
ZIP/Postal Code
07901
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Robert Aiken
Email
Robert.Aiken@atlantichealth.org
First Name & Middle Initial & Last Name & Degree
Robert Aiken
Facility Name
Albany Medical Center
City
Albany
State/Province
New York
ZIP/Postal Code
12208
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lauren Weintraub, MD
Email
weintrl@amc.edu
First Name & Middle Initial & Last Name & Degree
Lauren Weintraub, MD
Facility Name
Children's Hospital at Montefiore Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Adilia Hormigo, MD, PhD
Email
adilia.hormigo@einsteinmed.edu
First Name & Middle Initial & Last Name & Degree
Adilia Hormigo, MD, PhD
Facility Name
Montefiore Medical Park
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Adilia Hormigo, MD, PhD
Email
adilia.hormigo@einsteinmed.edu
First Name & Middle Initial & Last Name & Degree
Adilia Hormigo, MD, PhD
Facility Name
Columbia University Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10032
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Aya Haggiagi
Email
amh2237@cumc.columbia.edu
First Name & Middle Initial & Last Name & Degree
Aya Haggiagi
Facility Name
Levine Cancer Institute/ Atrium Health
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ashley Sumrall, MD
Email
ashley.sumrall@atriumhealth.org
First Name & Middle Initial & Last Name & Degree
Ashley Sumrall, MD
Facility Name
Duke Cancer Institute
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27710
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Margaret Johnson, MD, MPH
Email
margaret.o.johnson@duke.edu
First Name & Middle Initial & Last Name & Degree
Margaret Johnson, MD, MPH
Facility Name
Cincinnati Children's Hospital Medical Center
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45229
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Peter de Blank, MD
Email
cancer@cchmc.org
First Name & Middle Initial & Last Name & Degree
Peter de Blank, MD
Facility Name
Cleveland Clinic
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christine Cordova, MD
Email
cordovc@ccf.org
First Name & Middle Initial & Last Name & Degree
Christine Cordova, MD
Facility Name
Ohio Statue University
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shirley Ong, MD
Email
Shirley.Ong@osumc.edu
First Name & Middle Initial & Last Name & Degree
Shirley Ong, MD
Facility Name
University of Oklahoma Peggy and Charles Stephenson Cancer Center
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73104
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maya Hrachova, DO
Email
maya-hrachova@ouhsc.edu
First Name & Middle Initial & Last Name & Degree
Maya Hrachova, DO
Facility Name
Providence Health and Services St. Vincent Medical Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Prakash Ambady
Email
Prakash.Ambady@providence.org
First Name & Middle Initial & Last Name & Degree
Prakash Ambady, MB, MD
Facility Name
University of Pennsylvania
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stephen Bagley, MD
Email
sbagley@pennmedicine.upenn.edu
First Name & Middle Initial & Last Name & Degree
Stephen Bagley, MD
Facility Name
Thomas Jefferson University
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nina Martinez, MD
Email
nina.martinez@jefferson.edu
First Name & Middle Initial & Last Name & Degree
Nina Martinez, MD
Facility Name
UPMC Hillman Cancer Center
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15232
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Frank Lieberman, MD
Email
liebermanf@upmc.edu
First Name & Middle Initial & Last Name & Degree
Frank Lieberman, MD
Facility Name
Neuro-Oncology Associates
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Karen Fink, MD, PhD
Email
karenfin@baylorhealth.edu
First Name & Middle Initial & Last Name & Degree
Karen Fink, MD, PhD
Facility Name
University of Texas Southwestern Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Daniel Bowers, MD
Email
daniel.bowers@utsouthwestern.edu
First Name & Middle Initial & Last Name & Degree
Daniel Bowers, MD
Facility Name
University of Texas MD Anderson Cancer Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nazanin Majd
Email
NKMajd@mdanderson.org
First Name & Middle Initial & Last Name & Degree
Nazanin Majd
Facility Name
UT Health Science Center Houston Department of Neurosurgery
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jay-Jiguang Zhu, MD
Email
Jay.Jiguang.Zhu@uth.tmc.edu
First Name & Middle Initial & Last Name & Degree
Jay-Jiguang Zhu, MD
Facility Name
University of Utah - Huntsman Cancer Institute
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84112
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rachel Kingsford
Phone
801-585-0115
Email
rachel.kingsford@hci.utah.edu
First Name & Middle Initial & Last Name & Degree
Yuri Kida
Phone
801-646-4397
Email
yuri.kida@hci.utah.edu
First Name & Middle Initial & Last Name & Degree
Joe Mendez, MD
Facility Name
Inova Schar Cancer Institute
City
Fairfax
State/Province
Virginia
ZIP/Postal Code
22031
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Adam Cohen, MD
Email
adam.cohen@inova.org
First Name & Middle Initial & Last Name & Degree
Adam Cohen, MD
Facility Name
Children's Hospital of The King's Daughter
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23507
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Melissa Mark, MD
Email
melissa.mark@chkd.org
First Name & Middle Initial & Last Name & Degree
Melissa Mark, MD
Facility Name
University of Washington
City
Seattle
State/Province
Washington
ZIP/Postal Code
98195
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tresa McGranahan, MD
Email
tresa@uw.edu
First Name & Middle Initial & Last Name & Degree
Tresa McGranahan, MD
Facility Name
University Of Wisconsin - Madison
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53792
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ankush Bhatia, MD
Email
bhatia@neurology.wisc.edu
First Name & Middle Initial & Last Name & Degree
Ankush Bhatia, MD
Facility Name
Sydney Children's Hospital
City
Randwick
State/Province
New South Wales
ZIP/Postal Code
2031
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Ziegler, BS, MB, MD
Email
d.ziegler@unsw.edu.au
First Name & Middle Initial & Last Name & Degree
David Ziegler, BS, MB, MD
Facility Name
Royal North Shore Hospital
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Helen Wheeler, MD
Email
helen.wheeler@health.nsw.gov.au
First Name & Middle Initial & Last Name & Degree
Helen Wheeler, MD
Facility Name
Royal Hobart Hospital
City
Hobart
State/Province
Tasmania
ZIP/Postal Code
7000
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
John Heath
Email
john.heath@ths.tas.gov.au
First Name & Middle Initial & Last Name & Degree
John Heath
Facility Name
Olivia Newton-John Cancer Research Institute (ONJCRI)
City
Heidelberg
State/Province
Victoria
ZIP/Postal Code
3084
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lawrence Cher
Email
lawrence.cher@austin.org.au
First Name & Middle Initial & Last Name & Degree
Lawrence Cher
Facility Name
BC Cancer - The Vancouver Center
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 4E6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rebecca Harrison, MD
Email
rebecca.harrison@bccancer.bc.ca
First Name & Middle Initial & Last Name & Degree
Rebecca Harrison, MD
Facility Name
Sunnybrook Health Sciences Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mary Lim-Fat, MD
Email
maryjane.limfat@sunnybrook.ca
First Name & Middle Initial & Last Name & Degree
Mary Lim-Fat, MD
Facility Name
Princess Margaret Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 1X8
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Julie Bennett, MD
Email
julie.bennett@sickkids.ca
First Name & Middle Initial & Last Name & Degree
Julie Bennett, MD
Facility Name
Copenhagen University Hospital
City
Copenhagen
State/Province
Capital
ZIP/Postal Code
2100
Country
Denmark
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Søren Møller, MD
Email
soeren.moeller.01@regionh.dk
First Name & Middle Initial & Last Name & Degree
Søren Møller, MD
Facility Name
Aalborg Universitetshospital
City
Aalborg
State/Province
Nordjylland
ZIP/Postal Code
9000
Country
Denmark
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Charlotte Aaquist Haslund, MD
Email
cah@rn.dk
First Name & Middle Initial & Last Name & Degree
Charlotte Aaquist Haslund, MD
Facility Name
Odense Universitetshospital
City
Odense
State/Province
South Denmark
ZIP/Postal Code
5000
Country
Denmark
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rikke Dahlrot, MD
Email
rikke.dahlrot@rsyd.dk
First Name & Middle Initial & Last Name & Degree
Rikke Dahlrot, MD
Facility Name
Universitätsklinikum Heidelberg
City
Heidelberg
State/Province
Baden-Württemberg
ZIP/Postal Code
69120
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Antje Wick, MD
Email
antje.wick@med.uni-heidelberg.de
First Name & Middle Initial & Last Name & Degree
Antje Wick, MD
Facility Name
Universitätsklinikum Augsburg
City
Augsburg
State/Province
Bayern
ZIP/Postal Code
86156
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Frühwald, MD
Email
michael.fruehwald@klinikum-augsburg.de
First Name & Middle Initial & Last Name & Degree
Michael Frühwald, MD
Facility Name
University Clinic Regensburg
City
Regensburg
State/Province
Bayern
ZIP/Postal Code
93053
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Peter Hau, MD
Email
peter.hau@ukr.de
First Name & Middle Initial & Last Name & Degree
Peter Hau, MD
Facility Name
Klinikum der Johann-Wolfgang Goethe-Universitat
City
Frankfurt am Main
State/Province
Hessen
ZIP/Postal Code
60528
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Ronellenfitsch, MD
Email
michael.ronellenfitsch@kgu.de
First Name & Middle Initial & Last Name & Degree
Michael Ronellenfitsch, MD
Facility Name
Universitätsklinikum Bonn
City
Bonn
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
53127
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ulrich Herrlinger, MD
Email
ulrich.herrlinger@ukb.uni-bonn.de
First Name & Middle Initial & Last Name & Degree
Ulrich Herrlinger, MD
Facility Name
Universitätsklinikum Essen
City
Essen
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
45147
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Glas, MD
Email
martin.glas@uk-essen.de
First Name & Middle Initial & Last Name & Degree
Martin Glas, MD
Facility Name
Uniklinik Köln
City
Köln
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
50937
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Roland Goldbrunner, MD, PhD
Email
roland.goldbrunner@uk-koeln.de
First Name & Middle Initial & Last Name & Degree
Roland Goldbrunner, MD, PhD
Facility Name
Vivantes Klinikum Neukölln
City
Berlin
ZIP/Postal Code
12351
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andreas Jödicke, MD
Email
andreas.joedicke@vivantes.de
First Name & Middle Initial & Last Name & Degree
Andreas Jödicke, MD
Facility Name
Klinikum Mannheim Universitätsklinikum gGmbH
City
Manheim
ZIP/Postal Code
68167
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Katharina Sahm, MD
Email
katharina.sahm@umm.de
First Name & Middle Initial & Last Name & Degree
Katharina Sahm, MD
Facility Name
Universitätsklinikum Tübingen
City
Tübingen
ZIP/Postal Code
72076
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sylvia Kurz, MD
Email
sylvia.kurz@med.uni-tuebingen.de
First Name & Middle Initial & Last Name & Degree
Sylvia Kurz, MD
Facility Name
Sheba Medical Center
City
Ramat Gan
State/Province
Tel-Aviv
ZIP/Postal Code
5262100
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michal Yalon, MD, PhD
Email
michal.yalon@sheba.health.gov.il
First Name & Middle Initial & Last Name & Degree
Michal Yalon, MD, PhD
Facility Name
Soroka University Medical Centre
City
Be'er Sheva
ZIP/Postal Code
50937
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Abed El Salem Abu Quider, MD
Email
abeda@clalit.org.il
First Name & Middle Initial & Last Name & Degree
Abed El Salem Abu Quider, MD
Facility Name
Rambam Medical Center
City
Haifa
ZIP/Postal Code
31096
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Liat Oren
Email
li_oren@rmc.gov.il
First Name & Middle Initial & Last Name & Degree
Liat Oren
Facility Name
Hadassah Ein Kerem Medical Center
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alexander Lossos, MD
Email
alos@hadassah.org.il
First Name & Middle Initial & Last Name & Degree
Alexander Lossos, MD
Facility Name
Schneider Children's Medical Center of Israel
City
Petah Tikvah
ZIP/Postal Code
4920235
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Helen Toledano, MD
Email
Helent@clalit.org.il
First Name & Middle Initial & Last Name & Degree
Helen Toledano, MD
Facility Name
Rabin Medical Center
City
Petah Tikva
ZIP/Postal Code
49372
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shlomit Yust-Katz, MD
Email
shlomit2@clalit.org.il
First Name & Middle Initial & Last Name & Degree
Shlomit Yust-Katz, MD
Facility Name
Tel Aviv Sourasky Medical Center
City
Tel Aviv
ZIP/Postal Code
64239
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Deborah Blumenthal, MD
Email
Dvorab@tlvmc.gov.il
First Name & Middle Initial & Last Name & Degree
Deborah Blumenthal, MD
Facility Name
Ospedale Bellaria
City
Bologna
State/Province
Emilia-Romagna
ZIP/Postal Code
40139
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Enrico Franceschi, MD
Email
e.franceschi@ausl.bo.it
First Name & Middle Initial & Last Name & Degree
Enrico Franceschi, MD
Facility Name
Istituto Nazionale Tumori Regina Elena
City
Roma
State/Province
Lazio
ZIP/Postal Code
00144
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andrea Pace, MD, PhD
Email
andrea.pace@ifo.it
First Name & Middle Initial & Last Name & Degree
Andrea Pace, MD, PhD
Facility Name
Ospedale San Raffaele S.r.l.
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20132
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gaetano Finocchiaro, MD
Email
gaetano.finocchiaro@hsr.it
First Name & Middle Initial & Last Name & Degree
Gaetano Finocchiaro, MD
Facility Name
Fondazione IRCCS Di Rilievo Nazionale Istituto Nazionale Neurologico Carlo Besta
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20133
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paola Gaviani, MD
Email
paola.gaviani@istituto-besta.it
First Name & Middle Initial & Last Name & Degree
Paola Gaviani, MD
Facility Name
Istituto Clinico Humanitas
City
Rozzano
State/Province
Lombardia
ZIP/Postal Code
20089
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Matteo Simonelli, MD
Email
matteo.simonelli@humanitas.it
First Name & Middle Initial & Last Name & Degree
Matteo Simonelli, MD
Facility Name
Azienda Ospedaliera Città della Salute e della Scienza di Torino
City
Torino
State/Province
Piemonte
ZIP/Postal Code
10126
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alessia Pellerino, MD
Email
alessia.pellerino@unito.it
First Name & Middle Initial & Last Name & Degree
Alessia Pellerino, MD
Facility Name
Istituto Oncologico Veneto
City
Padova
State/Province
Veneto
ZIP/Postal Code
35128
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Giuseppe Lombardi, MD, PhD
Email
giuseppe.lombardi@iov.veneto.it
First Name & Middle Initial & Last Name & Degree
Giuseppe Lombardi, MD, PhD
Facility Name
CHA Bundang Medical Center
City
Bundang-Gu, Seongnam-Si
State/Province
Gyeonggido
ZIP/Postal Code
13496
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jaejoon Lim, MD
Email
coolppeng@naver.com
First Name & Middle Initial & Last Name & Degree
Jaejoon Lim, MD
Facility Name
National Cancer Center
City
Ilsandong-Gu, Goyang-Si
State/Province
Gyeonggido
ZIP/Postal Code
10408
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Heon Yoo, MD, PhD
Email
heonyoo@ncc.re.kr
First Name & Middle Initial & Last Name & Degree
Heon Yoo, MD, PhD
Facility Name
Samsung Medical Center
City
Gangnam-Gu
State/Province
Seoul Teugbyeolsi
ZIP/Postal Code
06351
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ji Won Lee, MD, PhD
Email
leejw.lee@samsung.com
First Name & Middle Initial & Last Name & Degree
Ji Won Lee, MD, PhD
Facility Name
Gangnam Severance Hospital, Yonsei University Health System
City
Gangnam
State/Province
Seoul Teugbyeolsi
ZIP/Postal Code
06273
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jun Won Kim, MD, PhD
Email
junwon@yuhs.ac
First Name & Middle Initial & Last Name & Degree
Jun Won Kim, MD, PhD
Facility Name
Seoul National University Hospital
City
Jongno-Gu
State/Province
Seoul Teugbyeolsi
ZIP/Postal Code
03080
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hyoung Jin Kang, MD
Email
kanghj@snu.ac.kr
First Name & Middle Initial & Last Name & Degree
Hyoung Jin Kang, MD
Facility Name
Severance Hospital Yonsei University Health System
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jong Hee Chang, MD, PhD
Email
changjh@yuhs.ac
First Name & Middle Initial & Last Name & Degree
Jong Hee Chang, MD, PhD
Facility Name
The Catholic University of Korea, Seoul St. Mary's Hospital
City
Seoul
ZIP/Postal Code
6591
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jae-Sung Park, MD, PhD
Email
jspark82@catholic.ac.kr
First Name & Middle Initial & Last Name & Degree
Jae-Sung Park, MD
Facility Name
Erasmus MC
City
Rotterdam
State/Province
Zuid-Holland
ZIP/Postal Code
3015 GD
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin van den Bent, MD, PhD
Email
m.vandenbent@erasmusmc.nl
First Name & Middle Initial & Last Name & Degree
Martin van den Bent, MD, PhD
Facility Name
Universitair Medisch Centrum Utrecht Cancer Center
City
Utrecht
ZIP/Postal Code
3584 CX
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tom J Snijders
Email
t.j.snijders@umcutrecht.nl
First Name & Middle Initial & Last Name & Degree
Tom J Snijders
Facility Name
Hospital Sant Joan de Deu
City
Esplugues De Llobregat
State/Province
Barcelona
ZIP/Postal Code
8950
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vicente Santa-Maria Lopez, MD
Email
vicente.santamaria@sjd.es
First Name & Middle Initial & Last Name & Degree
Vicente Santa-Maria Lopez, MD
Facility Name
Clinica Universidad Navarra
City
Pamplona
State/Province
Navarra
ZIP/Postal Code
31008
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jaime Gallego Perez de Larraya, MD
Email
jgallego@unav.es
First Name & Middle Initial & Last Name & Degree
Jaime Gallego Perez de Larraya, MD
Facility Name
Hospital Clinic de Barcelona
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Estela Pineda, MD
Email
epineda@clinic.cat
First Name & Middle Initial & Last Name & Degree
Estela Pineda, MD
Facility Name
Hospital Universitario Vall d'Hebron
City
Barcelona
ZIP/Postal Code
8035
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria Vieito Villar, MD, MSc
Email
mvieito@vhio.net
First Name & Middle Initial & Last Name & Degree
Maria Vieito Villar, MD, MSc
Facility Name
Hospital Infantil Universitario Niño Jesus
City
Madrid
ZIP/Postal Code
28009
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alvaro Lassaletta, MD
Email
lassaalvaro@yahoo.com
First Name & Middle Initial & Last Name & Degree
Alvaro Lassaletta, MD
Facility Name
Hospital Universitario 12 de Octubre
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Juan Manuel Sepulveda Sánchez, MD
Email
sepulvedasanchez@seom.org
First Name & Middle Initial & Last Name & Degree
Juan Manuel Sepulveda Sánchez, MD
Facility Name
Hospital Universitario HM Sanchinarro
City
Madrid
ZIP/Postal Code
28050
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gema Maria Garcia Ledo
Email
gmgarcialedo@hmhospitales.com
First Name & Middle Initial & Last Name & Degree
Gema Maria Garcia Ledo
Facility Name
Hospital Universitari i Politecnic La Fe de Valencia
City
Valencia
ZIP/Postal Code
46026
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Regina Gironés Sarrió, MD
Email
girones_reg@gva.es
First Name & Middle Initial & Last Name & Degree
Regina Gironés Sarrió, MD
Facility Name
Hospital Universitari i Politecnic La Fe de Valencia
City
Valencia
ZIP/Postal Code
46026
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Antonio Juan Ribelles, MD
Email
juan_antrib@gva.es
First Name & Middle Initial & Last Name & Degree
Antonio Juan Ribelles, MD
Facility Name
Centre Hospitalier Universitaire Vaudois
City
Lausanne
State/Province
Vaud
ZIP/Postal Code
1011
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andreas Hottinger, MD, PhD
Email
andreas.hottinger@chuv.ch
First Name & Middle Initial & Last Name & Degree
Andreas Hottinger, MD, PhD
Facility Name
Universitätsspital Zürich
City
Zürich
ZIP/Postal Code
8091
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Emilie Le Rhun, MD, PhD
Email
emilie.lerhun@usz.ch
First Name & Middle Initial & Last Name & Degree
Emilie Le Rhun, MD, PhD
Facility Name
Addenbrooke's Hospital
City
Cambridge
State/Province
Cambridgeshire
ZIP/Postal Code
CB2 0QQ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fiona Harris, MBBS, MD
Email
f.harris3@nhs.net
First Name & Middle Initial & Last Name & Degree
Fiona Harris, MBBS, MD
Facility Name
Beatson West of Scotland Cancer Centre
City
Glasgow
State/Province
Lanarkshire
ZIP/Postal Code
G12 0YN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stefan Nowicki, MD, PhD
Email
stefan.nowicki@ggc.scot.nhs.uk
First Name & Middle Initial & Last Name & Degree
Stefan Nowicki, MD, PhD
Facility Name
Royal Hospital for Children (Glasgow)
City
Glasgow
State/Province
Lanarkshire
ZIP/Postal Code
G51 4TF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jairam Sastry, MD
Email
jairam.sastry@ggc.scot.nhs.uk
First Name & Middle Initial & Last Name & Degree
Jairam Sastry, MD
Facility Name
Clatterbridge Cancer Centre - Liverpool
City
Liverpool
State/Province
Lancashire
ZIP/Postal Code
L7 8YA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shaveta Mehta, MD, PhD
Email
shaveta.mehta1@nhs.net
First Name & Middle Initial & Last Name & Degree
Shaveta Mehta, MD, PhD
Facility Name
The Christie NHS Foundation Trust
City
Manchester
State/Province
Lancashire
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Catherine McBain, MD
Email
catherine.mcbain1@nhs.net
First Name & Middle Initial & Last Name & Degree
Catherine McBain, MD
Facility Name
The Royal Marsden in Sutton, Surrey
City
Sutton
State/Province
Surrey
ZIP/Postal Code
SM2 5PT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fernando Carceller, MD
Email
fernando.carceller@rmh.nhs.uk
First Name & Middle Initial & Last Name & Degree
Fernando Carceller, MD
Facility Name
Royal Victoria Infirmary
City
Newcastle Upon Tyne
State/Province
Tyne And Wear
ZIP/Postal Code
NE1 4LP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joanne Lewis, MRCPCH
Email
joanne.lewis@nhs.net
First Name & Middle Initial & Last Name & Degree
Joanne Lewis, MRCPCH
Facility Name
Freeman Hospital
City
Newcastle Upon Tyne
State/Province
Tyne And Wear
ZIP/Postal Code
NE7 7DN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joanne Lewis, MRCPCH
Email
joanne.lewis@nhs.net
First Name & Middle Initial & Last Name & Degree
Joanne Lewis, MRCPCH
Facility Name
St James University Hospital
City
Leeds
State/Province
West Yorkshire
ZIP/Postal Code
LS9 7TF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Susan Short, MD, MRCPCH
Email
s.c.short@leeds.ac.uk
First Name & Middle Initial & Last Name & Degree
Susan Short, MD, MRCPCH
Facility Name
The Leeds Teaching Hospitals NHS Trust, Leeds General Infimary
City
Leeds
ZIP/Postal Code
LS1 3EX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Simone Wilkins, MD
Email
simonewilkins@nhs.net
First Name & Middle Initial & Last Name & Degree
Simone Wilkins, MD

12. IPD Sharing Statement

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ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

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