Remote Ischemic Conditioning and Dynamic Cerebral Autoregulation in Patients With Intracranial and Extracranial Arteriosclerosis

Inclusion Criteria: Age≥18 years, < 80 years, regardless of sex; Patients with clinically definite diagnosis of intracranial and extracranial atherosclerosis. Baseline Glasgow Coma Scale (GCS) ≥8; Be able to accept remote ischemic conditioning; Bilateral temporal windows were well penetrated; Signed and dated informed consent is obtained Exclusion Criteria: Patients who undergo intravenous thrombolysis or endovascular treatment; Patients with consciousness disorder or restlessness who cannot cooperate with dynamic cerebral autoregulation; Patients whose stable cerebral blood flow velocity envelope cannot be obtained by transcranial Doppler ultrasound or whose cerebral blood vessels have not been detected; Patients with severe arrhythmia (frequent ventricular or supraventricular arrhythmia diagnosed by 24 hours dynamic ECG), hyperthyroidism, severe anemia, unstable blood pressure and other factors affecting the hemodynamics; CT shows cerebral hemorrhagic diseases: hemorrhagic stroke, epidural hematoma, subdural hematoma, intracranial hematoma, ventricular hemorrhage, subarachnoid hemorrhage, etc; Other intracranial lesions, such as cerebrovascular malformations, cerebral venous lesions, tumors and other diseases involving the brain craniocerebral planning for surgical treatment; Other serious diseases and have a life expectancy of less than 3 months; Serious blood system diseases or severe coagulation dysfunction; Severe organ dysfunction or failure; Previously received remote ischemic conditioning or similar treatment; Contraindications of remote ischemic conditioning, such as severe soft tissue injury, fracture or vascular injury, peripheral vascular disease in the contralateral upper limb; Unqualified laboratory test indicators: Aspartate aminotransferase or alanine aminotransferase was 3 times higher than the upper limit of normal range, serum creatinine was > 265umol/l (> 3mg/dl), platelet was < 100×109/ l, international normalized ratio (INR), activated partial thromboplastin time (APTT), prothrombin time (PT) were above the upper limit of normal range; Pregnant or lactating women; Participating in other clinical investigators, or having participated in other clinical investigators within 3 months before enrollment; Patients who do not follow up or have poor treatment compliance; Other conditions deemed inappropriate for inclusion by the investigator