Optimal rTMS for Cognitive Deficits and Negative Symptoms in Schizophrenia
Schizophrenia, Negative Symptoms in Schizophrenia, Cognitive Impairment
About this trial
This is an interventional treatment trial for Schizophrenia
Eligibility Criteria
Inclusion Criteria: Met the Diagnostic and Statistical Manual of Mental Disorders, Five Edition (DSM-V) diagnostic criteria for schizophrenia and the diagnosis was verified by an experienced psychiatrist based on the Mini-International Neuropsychiatric Interview (MINI) 7.0 . Age between 18 and 60. Patients with prominently negative symptoms, which was defined as: PANSS negative subscore≥15 points and one of items N1-N7 scoring≥4. All patients were in stable clinical conditions (reduction rate of PANSS score<10% within 4 weeks), stable antipsychotic treatment for at least 4 weeks, and able to provide informed consent. Exclusion Criteria: Any contraindication for rTMS (e.g., intracranial metal, pacemakers, cochlear and intracranial hypertension). Unstable clinical condition (e.g., being aggressive and uncooperative). Current substance abuse. Any other psychiatric diagnosis. Significant medical condition including neurological disease, severe cardiovascular, hepatic, renal diseases. Previous treatment with modified electric convulsive therapy (MECT) within 3 months before enrollment.
Sites / Locations
- Shanghai Xuhui Mental Health CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Sham Comparator
Active rTMS over bilateral dorsolateral prefrontal cortex
Active rTMS over left dorsolateral prefrontal cortex
Sham rTMS over bilateral dorsolateral prefrontal cortex
Active rTMS over bilateral dorsolateral prefrontal cortex. Participants will receive up to 20 rTMS sessions within the 4-week treatment period.
Active rTMS over left dorsolateral prefrontal cortex and sham rTMS over right dorsolateral prefrontal cortex. Participants will receive up to 20 rTMS sessions within the 4-week treatment period.
Sham rTMS over bilateral dorsolateral prefrontal cortex. Participants will receive up to 20 rTMS sessions within the 4-week treatment period.