Probiotic Supplementation in Extremely Preterm Infants in Scandinavia (PEPS)
Necrotizing Enterocolitis, Death, Sepsis Newborn
About this trial
This is an interventional prevention trial for Necrotizing Enterocolitis focused on measuring Probiotics, NEC, Extreme prematurity, Feeding tolerance
Eligibility Criteria
Inclusion Criteria: -All extremly preterm infants born beween gestational age 22+0 to 27+6 Exclusion Criteria: Patients with severe complications and low chance of survival detected wihin the first 72 hours of life Patients with major congenital-anomalies Patients included in other interventional trials with the same or overlapping oucome measures.
Sites / Locations
- Karolinska University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Probiotic group
Control group
Probiotic group: 0,5 g per day of ProPrems®, including a combination of Bifidobacterium infantis Bb-02 (DSM 33361) 300 million, Bifidobacterium lactis (BB-12®) 350 million and Streptococcus thermophilus (TH-4®) 350 million. Mixed with 3 mills of breastmilk
Control group receives 3 mills of breastmilk without additives