Exercise for Better Bones - Day or Night?
Overweight
About this trial
This is an interventional other trial for Overweight
Eligibility Criteria
Inclusion Criteria: Postmenopausal women within 1-10 yr after menopause BMI 18.5-29.9 kg/m2 Healthy as determined by a screening physical examination and blood chemistry related to thyroid, liver, kidney, and lipid profile within normal range No osteoporosis as determined by dual energy x-ray absorptiometry (DEXA) scan at femoral neck or total spinal region No regular exercise for more than 30 minutes a day on more than 2 days a week and no physically active employment, such as maintenance and repair or delivery worker No regular use of medications known to interfere with calcium and bone metabolism from 6 weeks prior to the study to the end of study such as medications for heartburn, reflux, H2 blockers, diuretics, etc. such as antacids, Maalox, Pepcid AC, Nexium, Diuril, etc. Weight stable (within 5 lbs change) for at least 3 months prior to the start of the study Willing to maintain usual lifestyle and activities including the same wake-sleep schedule (go to sleep between 10:00 p.m. and midnight with an average 6-8 hours of sleep time) Refrain from the use of alcohol and nicotine (for example, cigarettes, cigars, and e-cigarettes) for the length of the study Able and willing to perform moderate intensity exercise without contraindications as determined by the Physical Activity Readiness Questionnaire Willing and able to stop any nutritional supplements including vitamin D supplements and calcium-containing medications (for instance, calcium-carbonate antacids) Willing not to use tanning booths during the study or not to travel to locations with a tropical climate two weeks prior to the study or during the washout period Exclusion Criteria: Hypertension with resting blood pressure higher than systolic 140 and diastolic 90 mmHg Within past 6 weeks, had nutrition supplements or medications known to affect calcium metabolism and appetite such as Antacids, Megace, antacids, heartburn, reflux, H2 blockers, diuretics, etc. Allergy to any food ingredients used in the provided diet Any disorders affecting nutrient absorption or metabolism, such as cystic fibrosis, lactose intolerance, celiac disease, etc. Any sleep disorders such as sleep apnea or regular use of an over-the-counter melatonin supplement Diabetes or taking medications known to affect bone such as Actos, Avandia, Invokana, etc. Engaged in moderate to vigorous exercise or regular exercise for more than 30 minutes/day on more than 2 days/week within past 6 weeks Repeated non-compliance with completing prescribed exercise sessions Within past 6 weeks, used tanning booths or traveled to location with a tropic climate Use of antibiotics (Amoxicillin, doxycycline, etc.), nonsteroidal anti-inflammatory drugs (aspirin, Celebrex, etc.), or probiotics (Lactobacillus, Bifidobacterium) within the past 6 weeks Irritable bowel syndrome, inflammatory bowel disease, or not having a bowel movement three days or longer
Sites / Locations
- USDA Grand Forks Human Nutrition Research CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Morning Exercise
Evening Exercise
Morning exercise session
Evening exercise session