High-intensity Intervals Versus Low-to-moderate-intensity Exercise Training in Patients With PAD (HIIT_PAD)
Peripheral Arterial Disease
About this trial
This is an interventional treatment trial for Peripheral Arterial Disease focused on measuring Exercise, Rehabilitation, Physical activity
Eligibility Criteria
Inclusion Criteria: Adult patients with symptomatic PAD (Fontaine stage IIa/b); ABI ≤ 0.9 or drop by 20% following exercise treadmill test 1; TBI ≤ 0.6 if incompressible arteries (diabetes and renal insufficiency); Signed written informed consent form. Exclusion Criteria: Age < 18; Unable to walk at 3.2 km/h on a treadmill (slope 0%) at least 300 m; Previous participate in SET programs ≤ 1 year; Prior leg/foot amputation; Contraindication to exercise Neurological and neuromuscular disorders and other comorbidities (orthopedic, rheumatologic) leading to gait abnormalities. Known Pregnancy Incapacity of discernment
Sites / Locations
- CHUVRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
High-intensity interval training group (HIIT)
Low-to-moderate intensity training group (LowMod group)
Exercise training sessions will consist in an alternation of brief periods (≤ 60 s) of work performed at high intensity and brief period of passive rest. Patient will be asked to complete 1 set of 10-15x60-s (or 2 sets of 5-7x60-s) walking intervals. This protocol will elicits moderate-to-severe claudication pain during exertion. The training intensity in the HIIT group will be set at ≥85% HRpeak recorded during the maximal cardiopulmonary exercise test.
Exercise training sessions will consist in an alternation of periods of work performed at moderate exercise intensity and period of passive rest. The training approach of the LowMod group will be similar to the training prescription usually adopted in patients with claudication. The exercise training intensity will be set at ≤76% HRpeak recorded during the maximal cardiopulmonary exercise test.