The Impact of Bed Rest, Aging and NMES on Skeletal Muscle
Disuse Atrophy (Muscle) of Lower Extremities, Muscle Function, Neuromuscular Electrical Stimulation
About this trial
This is an interventional basic science trial for Disuse Atrophy (Muscle) of Lower Extremities
Eligibility Criteria
Inclusion Criteria: Healthy Age between 18-30 or 65-80 years Injury free in the lower extremities (No previous or current knee injuries or knee pain) Normal weight Consumes normal diet Exclusion Criteria: Cognitive impairment affecting the ability to participate in the study. Health related contraindications to participating in the intervention (i.e., bed rest and/or NMES), such as eczema and rash on the lower extremities Smoker Obesity Not able to speak or understand Danish. Acute or chronic diseases such as diabetes, cancer, embolism, infection, cardio-vascular diseases Use of medication which affects myofibrillar protein synthesis or the skeletal muscle tissue Use of other medication (e.g. anticoagulants, adrenal cortex hormone [within the last 3 months] etc.) Previous or current use of anabolic steroids Previous participation in research trials involving deuterium oxide or another stable isotope tracer
Sites / Locations
- Bispebjerg HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Bed rest- Control
Bed rest + NMES
One leg will be subjected to disuse by bed rest and will not receive further treatment during the bed rest period.
One leg will be subjected to disuse by bed rest and will in addition receive neuromuscular electrical stimulation of the quadriceps muscle 3 times/day.