Prevention of NAFLD and CVD Through Lifestyle Intervention (MAUCO+)
Non-Alcoholic Fatty Liver Disease, Gallstone Disease
About this trial
This is an interventional prevention trial for Non-Alcoholic Fatty Liver Disease focused on measuring Anti-inflammatory diet, Lifestyle modification, Physical Activity
Eligibility Criteria
Inclusion Criteria: With and without gallstones disease With various degrees of NAFLD (none too severe) Exclusion Criteria: Any significant comorbidity or physical limitation to undergo resistance exercise program Use of medications that alter muscle mass (e.g., corticosteroids) History of hepatitis B or C Use of hepatotoxic drugs
Sites / Locations
- Centro MAUCO+Recruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Physical exercise and dietary intervention for NAFLD
Standard of care
The exercise program will consist of muscular strength and aerobic exercises; additionally, each session will start and end with low intensity warm-up and cool down periods. The program will be divided in months. Months 1-2, twice a week directly-supervised exercises group sessions, and 1 telehealth session. Months 3-6, once a week directly-supervised group session and twice a week home-based telehealth. Months 7-12, Monthly telephone support. Months 12, 24 and 36, All participants (control and intervention arms) will receive a full evaluation. In the dietary intervention, investigators proposed a diet rich in anti-inflammatory components, legumes and in dietary fiber. The baseline evaluation of nutritional condition includes: anthropometry, bioimpedance analysis, hepatobiliary ultrasound, Fibroscan,blood lipids, and a battery of metabolic markers and a diet survey, Automated Self-Administered 24-hour Dietary Assessment Tool (ASA24). Both interventions are performed in parallel.
Participants in the control arm first have a baseline evaluation of the nutritional condition, with anthropometry evaluation, bioimpedance analysis, hepatobiliary ultrasound, Fibroscan, blood lipids, a battery of metabolic markers, and a diet survey, Automated Self-Administered 24-hour Dietary Assessment Tool (ASA24). After the evaluation period, participants received one counseling session, including written material, with advice to follow a healthy diet rich in fruits and vegetables, whole-grain foods, low in salt and sugars, and recommendations for an exercise plan of at least 30 minutes of aerobic exercise three times a week.