Back to resultsEfficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen (TILIA)
Primary Purpose
Viral Lung Infection and Acute Respiratory Failure
Status
Recruiting
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Tozorakimab
Placebo
Sponsored by
About this trial
This is an interventional treatment trial for Viral Lung Infection and Acute Respiratory Failure focused on measuring Acute Respiratory Failure, Acute Respiratory Distress Syndrome, Viral lung infection, Tozorakimab, Supplemental Oxygen, IL-33, COVID-19, SARS-CoV-2, Coronavirus Infections, Virus Diseases, SARS Coronavirus, MEDI3506, Respiratory Tract Infections, Infections, Lung Diseases, Influenza
Eligibility Criteria
Inclusion Criteria: Adult participants ≥ 18 years old at the time of signing the informed consent form. Patients hospitalised with viral lung infection. Hypoxaemia requiring treatment with supplemental O2. Hypoxaemia is defined as: SpO2 ≤ 90% OR SpO2 ≤ 92% AND one or both of the following: Radiographic infiltrates by CXR/CT compatible with viral lung infection per investigator judgement. Use of accessory muscles of respiration or RR (respiratory rate) > 22. Exclusion Criteria: Known fungal or parasitic lung infection, aspiration lung infection, lung abscess, or pulmonary sepsis. Bacterial co-infection is allowed, unless, in the opinion of the investigator, bacterial infection defines the severity of the participant's condition. Hypoxaemia caused primarily by extrapulmonary insult or by lung injury of non-infective aetiology. Ongoing IMV/ECMO at randomisation.
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Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Placebo Comparator
Arm Label
Tozorakimab
Placebo
Arm Description
Approximately 2902 participants will be randomized in a 1:1 ratio. Arm 1 (n=approximately 1451) will receive a single dose of tozorakimab.
Approximately 2902 participants will be randomized in a 1:1 ratio. Arm 2 (n=approximately 1451) will receive matching placebo.
Outcomes
Primary Outcome Measures
Proportion of participants who die or progress to Invasive Mechanical Ventilation (IMV) / Extracorporeal Membrane Oxygen (ECMO)
To evaluate the effect of tozorakimab versus placebo as an add on to Standard of Care (SoC) in participants with viral lung infection requiring supplemental oxygen on the prevention of death or progression to IMV/ECMO.
Secondary Outcome Measures
Proportion of participants who die
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on all-cause mortality.
Number of days alive and outside of Intensive Care Unit (ICU)
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on ICU stay.
Number of days alive and free of supplemental oxygen
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on the duration of oxygen supplementation.
Time to death or progression to Invasive Mechanical Ventilation (IMV) / Extracorporeal Membrane Oxygen (ECMO)
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on prolonging time to death or IMV/ECMO.
Proportion of participants who die or progress to Invasive Mechanical Ventilation (IMV) / Extracorporeal Membrane Oxygen (ECMO)
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on prolonging time to death or IMV/ECMO.
Time to death (all cause)
To evaluate the effect of Tozorakimab versus Placebo as add-on to Standard of Care (SoC) on prolonging time to death.
Proportion of participants who die
To evaluate the effect of Tozorakimab versus Placebo as add-on to Standard of Care (SoC) on prolonging time to death.
Number of days alive and free of Invasive Mechanical Ventilation (IMV) / Extracorporeal Membrane Oxygen (ECMO)
To evaluate the effect of Tozorakimab versus placebo as add-on to Standard of Care (SoC) on ventilator use.
Number of days alive and ventilator free
To evaluate the effect of Tozorakimab versus placebo as add-on to Standard of Care (SoC) on ventilator use.
Proportion of participants with Intensive Care Unit (ICU) admission or death
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on ICU admissions.
Proportion of participants with Intensive Care Unit (ICU) admission or death
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on ICU admissions.
Proportion of participants alive and discharged
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on duration of hospitalisation.
Proportion of participants alive and discharged
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on duration of hospitalisation.
Time to discharge
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on duration of hospitalisation.
Time to being off supplemental oxygen
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on duration of hospitalisation.
World Health Organization (WHO) 10-category ordinal Clinical Progression Scale
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on clinical status as assessed by the Investigator using WHO 10-category ordinal Clinical Progression Scale (0 least severe to 10 most severe).
Incidence of anti-drug antibodies
To evaluate the immunogenicity (presence of tozorakimab anti-drug antibodies in blood serum) in participants with viral lung infection requiring supplemental oxygen.
Baseline serum interleukin-33/soluble Suppression of Tumorgenicity 2 (IL-33/sST2) complex levels relative to primary endpoint
To evaluate the use of baseline serum IL-33/sST2 complex levels (U/mL) to predict treatment response with tozorakimab versus placebo as add on to Standard of Care (SoC).
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT05624450
Brief Title
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
Acronym
TILIA
Official Title
A Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab (MEDI3506) in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
Study Type
Interventional
2. Study Status
Record Verification Date
October 2023
Overall Recruitment Status
Recruiting
Study Start Date
December 13, 2022 (Actual)
Primary Completion Date
March 17, 2025 (Anticipated)
Study Completion Date
March 17, 2025 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
AstraZeneca
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Viral Lung Infection and Acute Respiratory Failure
Keywords
Acute Respiratory Failure, Acute Respiratory Distress Syndrome, Viral lung infection, Tozorakimab, Supplemental Oxygen, IL-33, COVID-19, SARS-CoV-2, Coronavirus Infections, Virus Diseases, SARS Coronavirus, MEDI3506, Respiratory Tract Infections, Infections, Lung Diseases, Influenza
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigator
Allocation
Randomized
Enrollment
2902 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Tozorakimab
Arm Type
Experimental
Arm Description
Approximately 2902 participants will be randomized in a 1:1 ratio. Arm 1 (n=approximately 1451) will receive a single dose of tozorakimab.
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Approximately 2902 participants will be randomized in a 1:1 ratio. Arm 2 (n=approximately 1451) will receive matching placebo.
Intervention Type
Drug
Intervention Name(s)
Tozorakimab
Other Intervention Name(s)
MEDI3506
Intervention Description
Single IV dose of tozorakimab on Day 1.
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Single IV dose of matching placebo on Day 1.
Primary Outcome Measure Information:
Title
Proportion of participants who die or progress to Invasive Mechanical Ventilation (IMV) / Extracorporeal Membrane Oxygen (ECMO)
Description
To evaluate the effect of tozorakimab versus placebo as an add on to Standard of Care (SoC) in participants with viral lung infection requiring supplemental oxygen on the prevention of death or progression to IMV/ECMO.
Time Frame
by Day 28
Secondary Outcome Measure Information:
Title
Proportion of participants who die
Description
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on all-cause mortality.
Time Frame
by Day 60
Title
Number of days alive and outside of Intensive Care Unit (ICU)
Description
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on ICU stay.
Time Frame
over 28 day period
Title
Number of days alive and free of supplemental oxygen
Description
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on the duration of oxygen supplementation.
Time Frame
over 28 day period
Title
Time to death or progression to Invasive Mechanical Ventilation (IMV) / Extracorporeal Membrane Oxygen (ECMO)
Description
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on prolonging time to death or IMV/ECMO.
Time Frame
over 28 day and 60 day period
Title
Proportion of participants who die or progress to Invasive Mechanical Ventilation (IMV) / Extracorporeal Membrane Oxygen (ECMO)
Description
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on prolonging time to death or IMV/ECMO.
Time Frame
by Day 60
Title
Time to death (all cause)
Description
To evaluate the effect of Tozorakimab versus Placebo as add-on to Standard of Care (SoC) on prolonging time to death.
Time Frame
over 28 day and 60 day period
Title
Proportion of participants who die
Description
To evaluate the effect of Tozorakimab versus Placebo as add-on to Standard of Care (SoC) on prolonging time to death.
Time Frame
by Day 28
Title
Number of days alive and free of Invasive Mechanical Ventilation (IMV) / Extracorporeal Membrane Oxygen (ECMO)
Description
To evaluate the effect of Tozorakimab versus placebo as add-on to Standard of Care (SoC) on ventilator use.
Time Frame
over 28 day and 60 day period
Title
Number of days alive and ventilator free
Description
To evaluate the effect of Tozorakimab versus placebo as add-on to Standard of Care (SoC) on ventilator use.
Time Frame
over 28 day and 60 day period
Title
Proportion of participants with Intensive Care Unit (ICU) admission or death
Description
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on ICU admissions.
Time Frame
by Day 28
Title
Proportion of participants with Intensive Care Unit (ICU) admission or death
Description
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on ICU admissions.
Time Frame
by Day 60
Title
Proportion of participants alive and discharged
Description
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on duration of hospitalisation.
Time Frame
by Day 28
Title
Proportion of participants alive and discharged
Description
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on duration of hospitalisation.
Time Frame
by Day 60
Title
Time to discharge
Description
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on duration of hospitalisation.
Time Frame
over 28 day and 60 day period
Title
Time to being off supplemental oxygen
Description
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on duration of hospitalisation.
Time Frame
over 28 day and 60 day period
Title
World Health Organization (WHO) 10-category ordinal Clinical Progression Scale
Description
To evaluate the effect of tozorakimab versus placebo as add-on to Standard of Care (SoC) on clinical status as assessed by the Investigator using WHO 10-category ordinal Clinical Progression Scale (0 least severe to 10 most severe).
Time Frame
by Day 60
Title
Incidence of anti-drug antibodies
Description
To evaluate the immunogenicity (presence of tozorakimab anti-drug antibodies in blood serum) in participants with viral lung infection requiring supplemental oxygen.
Time Frame
over 60 day period
Title
Baseline serum interleukin-33/soluble Suppression of Tumorgenicity 2 (IL-33/sST2) complex levels relative to primary endpoint
Description
To evaluate the use of baseline serum IL-33/sST2 complex levels (U/mL) to predict treatment response with tozorakimab versus placebo as add on to Standard of Care (SoC).
Time Frame
Day 1
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Adult participants ≥ 18 years old at the time of signing the informed consent form.
Patients hospitalised with viral lung infection.
Hypoxaemia requiring treatment with supplemental O2.
Hypoxaemia is defined as:
SpO2 ≤ 90% OR
SpO2 ≤ 92% AND one or both of the following:
Radiographic infiltrates by CXR/CT compatible with viral lung infection per investigator judgement.
Use of accessory muscles of respiration or RR (respiratory rate) > 22.
Exclusion Criteria:
Known fungal or parasitic lung infection, aspiration lung infection, lung abscess, or pulmonary sepsis. Bacterial co-infection is allowed, unless, in the opinion of the investigator, bacterial infection defines the severity of the participant's condition.
Hypoxaemia caused primarily by extrapulmonary insult or by lung injury of non-infective aetiology.
Ongoing IMV/ECMO at randomisation.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
AstraZeneca Clinical Study Information Center
Phone
1-877-240-9479
Email
information.center@astrazeneca.com
Facility Information:
Facility Name
Research Site
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85013
Country
United States
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85719
Country
United States
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Chula Vista
State/Province
California
ZIP/Postal Code
91911
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Fresno
State/Province
California
ZIP/Postal Code
93701
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
La Mesa
State/Province
California
ZIP/Postal Code
91942
Country
United States
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Newport Beach
State/Province
California
ZIP/Postal Code
92663
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Torrance
State/Province
California
ZIP/Postal Code
90505
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Denver
State/Province
Colorado
ZIP/Postal Code
80206
Country
United States
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20037
Country
United States
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Bradenton
State/Province
Florida
ZIP/Postal Code
34209
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Bradenton
State/Province
Florida
ZIP/Postal Code
34209
Country
United States
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Miami
State/Province
Florida
ZIP/Postal Code
33144
Country
United States
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33709
Country
United States
Individual Site Status
Withdrawn
Facility Name
Research Site
City
South Pasadena
State/Province
Florida
ZIP/Postal Code
33707
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30322
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Boise
State/Province
Idaho
ZIP/Postal Code
83702
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Elmhurst
State/Province
Illinois
ZIP/Postal Code
60126
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Evanston
State/Province
Illinois
ZIP/Postal Code
60201
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Fort Wayne
State/Province
Indiana
ZIP/Postal Code
46804
Country
United States
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kansas City
State/Province
Kansas
ZIP/Postal Code
66160
Country
United States
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Shreveport
State/Province
Louisiana
ZIP/Postal Code
71103
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Annapolis
State/Province
Maryland
ZIP/Postal Code
21401
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Silver Spring
State/Province
Maryland
ZIP/Postal Code
20910
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Springfield
State/Province
Massachusetts
ZIP/Postal Code
01199
Country
United States
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Worcester
State/Province
Massachusetts
ZIP/Postal Code
01655
Country
United States
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65212
Country
United States
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11203
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
New York
State/Province
New York
ZIP/Postal Code
10039
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Potsdam
State/Province
New York
ZIP/Postal Code
13676
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Chapel Hill
State/Province
North Carolina
ZIP/Postal Code
27514
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Greenville
State/Province
North Carolina
ZIP/Postal Code
27834
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02903
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Sioux Falls
State/Province
South Dakota
ZIP/Postal Code
57105
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Dallas
State/Province
Texas
ZIP/Postal Code
75203
Country
United States
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Houston
State/Province
Texas
ZIP/Postal Code
77090
Country
United States
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22908
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Green Bay
State/Province
Wisconsin
ZIP/Postal Code
54311
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53295
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Buenos Aires
ZIP/Postal Code
C1046
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Research Site
City
Buenos Aires
ZIP/Postal Code
C1120AAF
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Buenos Aires
ZIP/Postal Code
C1180AAV
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Research Site
City
Caba
ZIP/Postal Code
C1221ADC
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Research Site
City
Caba
ZIP/Postal Code
C1425EOE
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Research Site
City
La Plata
ZIP/Postal Code
B1900AVG
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Research Site
City
Mar del Plata
ZIP/Postal Code
B7600GWV
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Research Site
City
Munro
ZIP/Postal Code
B1605FRE
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Research Site
City
Rosario
ZIP/Postal Code
S2000CVB
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Research Site
City
Adelaide
ZIP/Postal Code
5000
Country
Australia
Individual Site Status
Recruiting
Facility Name
Research Site
City
New Lambton Heights
ZIP/Postal Code
2305
Country
Australia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Port Macquarie
ZIP/Postal Code
2444
Country
Australia
Individual Site Status
Recruiting
Facility Name
Research Site
City
South Brisbane
ZIP/Postal Code
4101
Country
Australia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Ottignies
ZIP/Postal Code
1340
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Research Site
City
Yvoir
ZIP/Postal Code
5530
Country
Belgium
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Belo Horizonte
ZIP/Postal Code
30150-221
Country
Brazil
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Campinas
ZIP/Postal Code
13060-904
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Research Site
City
Caxias do Sul
ZIP/Postal Code
95070-560
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Research Site
City
Curitiba
ZIP/Postal Code
80215-901
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Research Site
City
Curitiba
ZIP/Postal Code
80730-150
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Research Site
City
Natal
ZIP/Postal Code
59025-050
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Research Site
City
Niterói
ZIP/Postal Code
24020-096
Country
Brazil
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Porto Alegre
ZIP/Postal Code
90020-090
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Research Site
City
Porto Alegre
ZIP/Postal Code
9061-000
Country
Brazil
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Ribeirão Preto
ZIP/Postal Code
14049-901
Country
Brazil
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Rio de Janeiro
ZIP/Postal Code
21040-900
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Research Site
City
Salvador
ZIP/Postal Code
40170-130
Country
Brazil
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Sao Jose Do Rio Preto
ZIP/Postal Code
15090-000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Research Site
City
Sao Paulo
ZIP/Postal Code
09323-900
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Research Site
City
São Paulo
ZIP/Postal Code
04004-030
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Research Site
City
Pernik
ZIP/Postal Code
2300
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Research Site
City
Pleven
ZIP/Postal Code
5800
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Research Site
City
Plovdiv
ZIP/Postal Code
4001
Country
Bulgaria
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Plovdiv
ZIP/Postal Code
4004
Country
Bulgaria
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Ruse
ZIP/Postal Code
7002
Country
Bulgaria
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Sliven
ZIP/Postal Code
8800
Country
Bulgaria
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1000
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1154
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1407
Country
Bulgaria
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1431
Country
Bulgaria
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1606
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Research Site
City
Varna
ZIP/Postal Code
9010
Country
Bulgaria
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 1N4
Country
Canada
Individual Site Status
Recruiting
Facility Name
Research Site
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6R 3J9
Country
Canada
Individual Site Status
Recruiting
Facility Name
Research Site
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 2M4
Country
Canada
Individual Site Status
Recruiting
Facility Name
Research Site
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2W 1S6
Country
Canada
Individual Site Status
Recruiting
Facility Name
Research Site
City
Saskatoon
State/Province
Saskatchewan
ZIP/Postal Code
S7N 0W8
Country
Canada
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
Individual Site Status
Recruiting
Facility Name
Research Site
City
Beijing
ZIP/Postal Code
100015
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Beijing
ZIP/Postal Code
100029
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Beijing
ZIP/Postal Code
101199
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Beijing
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Changsha
ZIP/Postal Code
410004
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Chengdu
ZIP/Postal Code
610000
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Chengdu
ZIP/Postal Code
610072
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Chongqing
ZIP/Postal Code
400010
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Fuyang
ZIP/Postal Code
236012
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Guangzhou
ZIP/Postal Code
510180
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Guangzhou
ZIP/Postal Code
510515
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Haikou
ZIP/Postal Code
570311
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Hangzhou
ZIP/Postal Code
310006
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Hangzhou
ZIP/Postal Code
310016
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Hefei
ZIP/Postal Code
230001
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Nanchang
ZIP/Postal Code
330006
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Qingdao
ZIP/Postal Code
266011
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
200025
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
200032
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
200240
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
CN-200433
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Shenzhen
ZIP/Postal Code
518020
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Tianjin
ZIP/Postal Code
300052
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Weifang
ZIP/Postal Code
261041
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Wuhan
ZIP/Postal Code
430023
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Wuhan
ZIP/Postal Code
430030
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Yantai
ZIP/Postal Code
264000
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Yinchuan
ZIP/Postal Code
750004
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Zhengzhou
ZIP/Postal Code
450000
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Bogota DC
ZIP/Postal Code
111121
Country
Colombia
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Floridablanca
ZIP/Postal Code
681004
Country
Colombia
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Medellin
ZIP/Postal Code
050021
Country
Colombia
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Soledad
ZIP/Postal Code
083001
Country
Colombia
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Villavicencio
ZIP/Postal Code
500001
Country
Colombia
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Benesov
ZIP/Postal Code
256 01
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Brno
ZIP/Postal Code
625 00
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kolin
ZIP/Postal Code
280 02
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kyjov
ZIP/Postal Code
697 01
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Mlada Boleslav
ZIP/Postal Code
293 01
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Praha 10
ZIP/Postal Code
100 34
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Praha 5
ZIP/Postal Code
150 30
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Aalborg
ZIP/Postal Code
9000
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Research Site
City
Aarhus N
ZIP/Postal Code
8200
Country
Denmark
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Copenhagen Ø
ZIP/Postal Code
2100
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Research Site
City
Hvidovre
ZIP/Postal Code
2650
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kolding
ZIP/Postal Code
6000
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Research Site
City
København
ZIP/Postal Code
2400
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Research Site
City
Odense C
ZIP/Postal Code
5000
Country
Denmark
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Vejle
ZIP/Postal Code
7100
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Research Site
City
Cairo
ZIP/Postal Code
11561
Country
Egypt
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Cairo
ZIP/Postal Code
11566
Country
Egypt
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
New Cairo
ZIP/Postal Code
11566
Country
Egypt
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Amiens Cedex 1
ZIP/Postal Code
80054
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Angers
ZIP/Postal Code
49033
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Dijon
ZIP/Postal Code
21000
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Le Coudray Cedex
ZIP/Postal Code
28630
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Montpellier Cedex 5
ZIP/Postal Code
34295
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Nantes Cedex 1
ZIP/Postal Code
44800
Country
France
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Orléans Cedex 2
ZIP/Postal Code
45100
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Strasbourg Cedex
ZIP/Postal Code
67098
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Strasbourg
ZIP/Postal Code
67091
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Tours
ZIP/Postal Code
37000
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Augsburg
ZIP/Postal Code
86156
Country
Germany
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Berlin
ZIP/Postal Code
10117
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Hannover
ZIP/Postal Code
30625
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Köln
ZIP/Postal Code
51109
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Leverkusen
ZIP/Postal Code
51375
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
München
ZIP/Postal Code
81675
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Rosenheim
ZIP/Postal Code
83022
Country
Germany
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Rostock
ZIP/Postal Code
18057
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Athens
ZIP/Postal Code
11527
Country
Greece
Individual Site Status
Recruiting
Facility Name
Research Site
City
Athens
ZIP/Postal Code
12462
Country
Greece
Individual Site Status
Recruiting
Facility Name
Research Site
City
Exohi Thessaloniki
ZIP/Postal Code
57010
Country
Greece
Individual Site Status
Recruiting
Facility Name
Research Site
City
Heraklion
ZIP/Postal Code
71500
Country
Greece
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Ioannina
ZIP/Postal Code
45500
Country
Greece
Individual Site Status
Recruiting
Facility Name
Research Site
City
Thessaloniki
ZIP/Postal Code
57010
Country
Greece
Individual Site Status
Recruiting
Facility Name
Research Site
City
Hong Kong
Country
Hong Kong
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Shatin
ZIP/Postal Code
00000
Country
Hong Kong
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Balassagyarmat
ZIP/Postal Code
2660
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Research Site
City
Budapest
ZIP/Postal Code
1082
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Research Site
City
Budapest
ZIP/Postal Code
1121
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Research Site
City
Győr
ZIP/Postal Code
9024
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kistarcsa
ZIP/Postal Code
2143
Country
Hungary
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Nyíregyháza
ZIP/Postal Code
4400
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Research Site
City
Pécs
ZIP/Postal Code
7624
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Research Site
City
Ahmedabad
ZIP/Postal Code
380054
Country
India
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Ahmedabad
ZIP/Postal Code
382415
Country
India
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Belagavi
ZIP/Postal Code
590010
Country
India
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Chennai
ZIP/Postal Code
600113
Country
India
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Gurgaon
ZIP/Postal Code
122001
Country
India
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Gurugram
ZIP/Postal Code
122001
Country
India
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Hyderabad
ZIP/Postal Code
500004
Country
India
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Mumbai
ZIP/Postal Code
400008
Country
India
Individual Site Status
Withdrawn
Facility Name
Research Site
City
New Delhi
ZIP/Postal Code
110017
Country
India
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
New Delhi
ZIP/Postal Code
110029
Country
India
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
New Delhi
ZIP/Postal Code
110060
Country
India
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Pune
ZIP/Postal Code
411030
Country
India
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Thane
ZIP/Postal Code
401107
Country
India
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Afula
ZIP/Postal Code
18341
Country
Israel
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Ashkelon
ZIP/Postal Code
7830604
Country
Israel
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Beer Sheva
ZIP/Postal Code
8410101
Country
Israel
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Haifa
ZIP/Postal Code
34362
Country
Israel
Individual Site Status
Recruiting
Facility Name
Research Site
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
Individual Site Status
Recruiting
Facility Name
Research Site
City
Petah Tikva
ZIP/Postal Code
4941492
Country
Israel
Individual Site Status
Recruiting
Facility Name
Research Site
City
Ramat Gan
ZIP/Postal Code
52621
Country
Israel
Individual Site Status
Recruiting
Facility Name
Research Site
City
Rehovot
ZIP/Postal Code
76100
Country
Israel
Individual Site Status
Recruiting
Facility Name
Research Site
City
Arezzo
ZIP/Postal Code
52100
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Brescia
ZIP/Postal Code
25123
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Roma
ZIP/Postal Code
00149
Country
Italy
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Rozzano
ZIP/Postal Code
20089
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Torino
ZIP/Postal Code
10149
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Fukuoka-shi
ZIP/Postal Code
814-0180
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Gifu-shi
ZIP/Postal Code
502-8558
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Hiroshima-shi
ZIP/Postal Code
734-8530
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Hiroshima-shi
ZIP/Postal Code
734-8551
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Hitachi-shi
ZIP/Postal Code
317-0077
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Isehara-shi
ZIP/Postal Code
259-1193
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Izumisano-shi
ZIP/Postal Code
598-8577
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Izumo-shi
ZIP/Postal Code
693-8501
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Kagoshima-shi
ZIP/Postal Code
890-8520
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Kamakura-shi
ZIP/Postal Code
247-8533
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kamogawa-shi
ZIP/Postal Code
296-8602
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kanazawa-shi
ZIP/Postal Code
920-8641
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kanazawa-shi
ZIP/Postal Code
920-8650
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kasuga-shi
ZIP/Postal Code
816-0864
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kawasaki-shi
ZIP/Postal Code
216-8511
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Koshigaya-shi
ZIP/Postal Code
343-8555
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kusatsu-shi
ZIP/Postal Code
525-8585
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kyoto-shi
ZIP/Postal Code
602-8566
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Kyoto-shi
ZIP/Postal Code
612-8555
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Maebashi-shi
ZIP/Postal Code
371-0811
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Nagoya-shi
ZIP/Postal Code
466-8560
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Nakagami-gun
ZIP/Postal Code
903-0215
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Nerima-ku
ZIP/Postal Code
179-0072
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Okayama-shi
ZIP/Postal Code
702-8055
Country
Japan
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Okazaki-shi
ZIP/Postal Code
444-0827
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Omuta-shi
ZIP/Postal Code
837-0911
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Osaka-shi
ZIP/Postal Code
534-0021
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Osaka-shi
ZIP/Postal Code
543-0035
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Sapporo-shi
ZIP/Postal Code
062-0931
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Sapporo-shi
ZIP/Postal Code
063-0005
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Shinagawa-ku
ZIP/Postal Code
142-8666
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Shinjuku-ku
ZIP/Postal Code
162-8655
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Suita-shi
ZIP/Postal Code
565-0871
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Tachikawa-shi
ZIP/Postal Code
190-8531
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Takamatsu-shi
ZIP/Postal Code
760-0018
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Urasoe-shi
ZIP/Postal Code
901-2132
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Ureshino-shi
ZIP/Postal Code
843-0393
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Yokohama-shi
ZIP/Postal Code
236-0004
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Yokohama-shi
ZIP/Postal Code
241-0811
Country
Japan
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Yokohama-shi
ZIP/Postal Code
245-8575
Country
Japan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Daegu
ZIP/Postal Code
42415
Country
Korea, Republic of
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Jeonju
ZIP/Postal Code
54907
Country
Korea, Republic of
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Seoul
ZIP/Postal Code
143-729
Country
Korea, Republic of
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Kota Kinabalu
ZIP/Postal Code
88200
Country
Malaysia
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Kuala Lumpur
ZIP/Postal Code
59100
Country
Malaysia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kuantan
ZIP/Postal Code
25200
Country
Malaysia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kubang Kerian
ZIP/Postal Code
16150
Country
Malaysia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Melaka
ZIP/Postal Code
75400
Country
Malaysia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Petaling Jaya
ZIP/Postal Code
47500
Country
Malaysia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Pulau Pinang
ZIP/Postal Code
10450
Country
Malaysia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Sarawak Miri
ZIP/Postal Code
98000
Country
Malaysia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Shah Alam
ZIP/Postal Code
40000
Country
Malaysia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Aguascalientes
ZIP/Postal Code
20259
Country
Mexico
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Guadalajara
ZIP/Postal Code
44280
Country
Mexico
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Guadalajara
ZIP/Postal Code
44340
Country
Mexico
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Mexico City
ZIP/Postal Code
06720
Country
Mexico
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Monterrey
ZIP/Postal Code
64460
Country
Mexico
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
San Luis Potosi
ZIP/Postal Code
78250
Country
Mexico
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Tlalpan
ZIP/Postal Code
14050
Country
Mexico
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Tlalpan
ZIP/Postal Code
14080
Country
Mexico
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Cusco
ZIP/Postal Code
CUSCO 01
Country
Peru
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
el Agustino
ZIP/Postal Code
LIMA 10
Country
Peru
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Lima
ZIP/Postal Code
15088
Country
Peru
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Lima
ZIP/Postal Code
15324
Country
Peru
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Lima
ZIP/Postal Code
LIMA 01
Country
Peru
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Lima
ZIP/Postal Code
LIMA 1
Country
Peru
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Lima
ZIP/Postal Code
LIMA 31
Country
Peru
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Piura
ZIP/Postal Code
05
Country
Peru
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Cebu
ZIP/Postal Code
6000
Country
Philippines
Individual Site Status
Recruiting
Facility Name
Research Site
City
Cebu
ZIP/Postal Code
6000
Country
Philippines
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Iloilo City
Country
Philippines
Individual Site Status
Recruiting
Facility Name
Research Site
City
Manila
ZIP/Postal Code
1000
Country
Philippines
Individual Site Status
Recruiting
Facility Name
Research Site
City
Quezon City
ZIP/Postal Code
1100
Country
Philippines
Individual Site Status
Recruiting
Facility Name
Research Site
City
Quezon City
ZIP/Postal Code
1109
Country
Philippines
Individual Site Status
Recruiting
Facility Name
Research Site
City
Chrzanów
ZIP/Postal Code
32-500
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Rzeszów
ZIP/Postal Code
35-241
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Warszawa
ZIP/Postal Code
00-416
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Warszawa
ZIP/Postal Code
01-138
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Wroclaw
ZIP/Postal Code
51-149
Country
Poland
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Łódź
ZIP/Postal Code
91-347
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Łęczna
ZIP/Postal Code
21-010
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Bucharest
ZIP/Postal Code
21105
Country
Romania
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Jeddah
ZIP/Postal Code
21423
Country
Saudi Arabia
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Riyadh
ZIP/Postal Code
11426
Country
Saudi Arabia
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Riyadh
ZIP/Postal Code
12231
Country
Saudi Arabia
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Riyadh
ZIP/Postal Code
12372
Country
Saudi Arabia
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Bratislava
ZIP/Postal Code
82606
Country
Slovakia
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Košice
ZIP/Postal Code
04001
Country
Slovakia
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Trnava
ZIP/Postal Code
91775
Country
Slovakia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Observatory
ZIP/Postal Code
7925
Country
South Africa
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Parktown
ZIP/Postal Code
2193
Country
South Africa
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Soweto
ZIP/Postal Code
2013
Country
South Africa
Individual Site Status
Recruiting
Facility Name
Research Site
City
Westdene
ZIP/Postal Code
2092
Country
South Africa
Individual Site Status
Recruiting
Facility Name
Research Site
City
Barcelona
ZIP/Postal Code
08003
Country
Spain
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Ourense
ZIP/Postal Code
32005
Country
Spain
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Palma de Mallorca
ZIP/Postal Code
07010
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Pamplona
ZIP/Postal Code
31008
Country
Spain
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Santander
ZIP/Postal Code
39008
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Valencia
ZIP/Postal Code
46010
Country
Spain
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Lund
ZIP/Postal Code
22185
Country
Sweden
Individual Site Status
Active, not recruiting
Facility Name
Research Site
City
Malmö
ZIP/Postal Code
20502
Country
Sweden
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Stockholm
ZIP/Postal Code
18288
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Research Site
City
Umeå
ZIP/Postal Code
90185
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Research Site
City
Västerås
ZIP/Postal Code
72189
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kaohsiung
ZIP/Postal Code
80756
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Taichung
ZIP/Postal Code
40705
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Taipei
ZIP/Postal Code
0116
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Taipei
ZIP/Postal Code
10002
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Taipei
ZIP/Postal Code
112
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Taoyuan City
ZIP/Postal Code
330
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Research Site
City
Bangkok
ZIP/Postal Code
10400
Country
Thailand
Individual Site Status
Recruiting
Facility Name
Research Site
City
Bangkok
ZIP/Postal Code
10700
Country
Thailand
Individual Site Status
Recruiting
Facility Name
Research Site
City
Chiang Mai
ZIP/Postal Code
50200
Country
Thailand
Individual Site Status
Recruiting
Facility Name
Research Site
City
Khon-Kaen
ZIP/Postal Code
40002
Country
Thailand
Individual Site Status
Recruiting
Facility Name
Research Site
City
Phutthamonthon
ZIP/Postal Code
73170
Country
Thailand
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Ankara
ZIP/Postal Code
06800
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Research Site
City
Diyarbakir
ZIP/Postal Code
21280
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Research Site
City
Istambul
ZIP/Postal Code
34899
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Research Site
City
Istanbul
ZIP/Postal Code
34069
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Research Site
City
Izmir
ZIP/Postal Code
35110
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Research Site
City
Malatya
ZIP/Postal Code
44280
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Research Site
City
Bristol
ZIP/Postal Code
BS105NB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Dundee
ZIP/Postal Code
DD1 9SY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Glasgow
ZIP/Postal Code
G4 0SF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Glasgow
ZIP/Postal Code
G51 4TF
Country
United Kingdom
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Hampshire
ZIP/Postal Code
SO16 6YD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Leeds
ZIP/Postal Code
LS9 7TF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Leicester
ZIP/Postal Code
LE3 9QP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
London
ZIP/Postal Code
W2 1NY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
London
ZIP/Postal Code
W6 8RF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Oxford
ZIP/Postal Code
OX3 9DU
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Prescot
ZIP/Postal Code
L35 5DR
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Tyne And Wear
ZIP/Postal Code
NE29 8NH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Wythenshawe
ZIP/Postal Code
M23 9LT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Hanoi
ZIP/Postal Code
100000
Country
Vietnam
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Hanoi
ZIP/Postal Code
10000
Country
Vietnam
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Ho Chi Minh
ZIP/Postal Code
700000
Country
Vietnam
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Ho Chi Minh
Country
Vietnam
Individual Site Status
Withdrawn
Facility Name
Research Site
City
Hochiminh city
ZIP/Postal Code
700000
Country
Vietnam
Individual Site Status
Not yet recruiting
Facility Name
Research Site
City
Hue
ZIP/Postal Code
530000
Country
Vietnam
Individual Site Status
Not yet recruiting
12. IPD Sharing Statement
Plan to Share IPD
Yes
IPD Sharing Plan Description
Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal.
All request will be evaluated as per the AZ disclosure commitment:
https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. Yes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.
IPD Sharing Time Frame
AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please rerefer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
IPD Sharing Access Criteria
When a request has been approved AstraZeneca will provide access to the deidentified individual patient-level data in an approved sponsored tool . Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access. For additional details, please review the Disclosure Statements at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
IPD Sharing URL
https://astrazenecagroup-dt.pharmacm.com/DT/Home
Learn more about this trial
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
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