Impact of Transforaminal Epidural Steroid Injection in Lumbar Disc Prolpse on Micro RNA-155 Serum Level
Lumbar Disc Herniation
About this trial
This is an interventional treatment trial for Lumbar Disc Herniation
Eligibility Criteria
Inclusion Criteria: Patients with clinical evidence of disc bulge in the form of disc related radicular pain of >3 months duration, not responding to conservative treatment and interfering with daily activities. The selected patients should have radiological evidence of posterolateral lumbar disc bulge by MRI lumbosacral. Exclusion Criteria: Patients with a history of spinal trauma, spinal surgery or spinal deformities. Patients with radiological evidence of any inflammatory or neoplastic lesion affecting the vertebral column or spinal cord. Patients with facet or hip osteoarthritis or sacroiliitis. Patients with severe lumbar disc prolapse causing lower limb weakness or sphincteric troubles. Patients with contraindications to interventions (sepsis, coagulopathy, or allergy from the used drugs). Patients with central or metabolic disorder known to cause cognitive dysfunction. Pregnant patients will be also excluded from our study.
Sites / Locations
- Mona HusseinRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
lumbar disc prolapse group
Control
46 patients diagnosed as having symptomatic lumbar disc prolapse
46 age and sex matched healthy controls