CAR T Cells in Patients With MMP2+ Recurrent or Progressive Glioblastoma

Inclusion Criteria: Documented informed consent of the subject and/or legally authorized representative. Agreement to allow the use of archival tissue from diagnostic tumor biopsies. Age 18 years and older. ECOG status of 0 or 1. Life expectancy ≥12 weeks. Subject has a prior histologically confirmed diagnosis of a grade 4 glioblastoma multiforme (GBM) or a prior histologically confirmed diagnosis of a grade 2 or 3 malignant glioma and now has radiographic progression consistent with a grade 4 GBM (IDH wild type), grade 4 diffuse astrocytoma (IDH mutant), or has a unifocal relapse of GBM. Relapsed disease: radiographic evidence of recurrence/progression of measurable disease after standard therapy and ≥ 12 weeks after completion of front-line radiation therapy. Confirmed MMP2+ tumor expression by IHC (≥20% moderate/high MMP2 score [2+ or 3+]). Adequate venous access to perform leukapheresis. No known contraindications to leukapheresis or steroids. In-range baseline laboratory values for WBC (>2000/dL [or ANC ≥1000/mm^3]), platelets (≥75000/mm^3), total bilirubin (≤1.5xULN), AST (≤2.5xULN), ALT (≤2.5xULN), serum creatinine (≤1.5xmg/dL), and oxygen saturation (≥95% on room air) Seronegative for human immunodeficiency virus (HIV) by antigen/antibody (Ag/Ab) testing. Seronegative for hepatitis B and/or hepatitis C virus. Women of childbearing potential must have a negative urine or serum pregnancy test. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test is required. Agreement by women AND men of childbearing potential to use an effective method of birth control or abstain from heterosexual activity for the course of the study through at least 3 months after the last dose of CHM-1101. (Childbearing potential is defined as not being surgically sterilized (women and men) or, for women, having not been free from menses for > 1 year.) Exclusion Criteria: Within 3 months of having received prior bevacizumab therapy at the time of enrollment. Not yet recovered from toxicities of prior therapy. Uncontrolled seizure activity and/or clinically evident progressive encephalopathy. History of allergic reactions attributed to compounds of similar chemical or biologic composition to study agent. Clinically significant uncontrolled illness. Active infection requiring antibiotics. Known history of HIV or hepatitis B or hepatitis C infection. Other active malignancy. Women only-pregnant or breastfeeding. Any other condition that would, in the Investigator's judgment, contraindicate the subject's participation in the clinical study due to safety concerns with clinical study procedures. Prospective subjects who, in the opinion of the Investigator, may not be able to comply with all study procedures (including compliance issues related to feasibility/logistics).