Pediatric Intensive Care Unit and Primary Immune Deficiency (PICUPID)
Immuno-Deficiency
About this trial
This is an interventional diagnostic trial for Immuno-Deficiency
Eligibility Criteria
Inclusion Criteria: Any child hospitalized in the Pediatric Resuscitation Unit for: Severe sepsis or septic shock including those without microbiological documentation or portal of entry found. ≥ 1 documented invasive infection with encapsulated germ (Streptococcus pneumoniae, group A streptococcus, Haemophilus influenzae, Neisseria meningitidis). An invasive infection with an unusual germ or an opportunistic infection: Bacterial: Salmonella, Tuberculosis, / Fungal: Aspergillosis, Cryptococcosis, Candidiasis / Parasitic: Toxoplasmosis, Pneumocystosis, Giarda lamblia / Viral: enterovirus, CMV, EBV, viral encephalitis Exclusion Criteria: Patient with known primary or secondary immunodeficiency: HIV, known neoplasia, immunosuppressive or immunomodulatory therapy, renal failure, nephrotic syndrome, hypoprotidemia, cirrhosis with hepatic insufficiency, sickle cell disease, splenectomy. Local-regional factors that may be responsible for infections: foreign body in the airways, history of ENT surgery or neurosurgery, history of fracture of the skull base, cystic fibrosis, chronic respiratory insufficiency. Refusal to sign the consent of the legal representative.
Sites / Locations
- Caen University Hospital
Arms of the Study
Arm 1
Other
Screening