May Noninvasive Mechanical Ventilation (NIV) and/or Continuous Positive Airway Pressure (CPAP) Increase the Bronchoalveolar Lavage (BAL) Salvage in Patients With Pulmonary Diseases? (PAP+BAL)
Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
About this trial
This is an interventional diagnostic trial for Chronic Obstructive Pulmonary Disease focused on measuring Bronchoalveolar Lavage, Noninvasive Mechanical Ventilation, Continuous Positive Airway Pressure, Bronchoscopy
Eligibility Criteria
Inclusion Criteria: Patients with diagnosed stable COPD (Stages 1-3) - experimental group; Patients with interstitial lung disease - experimental group Former and current smokers with normal lung function - potential control group 1; Never-smokers with normal lung ventilation - potential control group 2. Exclusion Criteria: No written, informed consent to participate in the research project. Severe respiratory failure (SaO2 < 90%) The patient qualified for home oxygen treatment or home mechanical ventilation Severe heart failure (NYHA class IV) COPD mMRC IV Myocardial infarction in the last two weeks or unstable angina Severe, particularly ventricular arrhythmias Platelet count < 20,000/ul INR > 2 or APPT > 36 sec Very severe obstruction: forced expiratory volume in 1 second (FEV1) < 30% of predicted.
Sites / Locations
- Pulmunology DepartmentRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
BAL + NIV
BAL + CPAP
Qualification for a specific type of ventilation (NIV or CPAP) will be carried out in a randomized manner by a specially created online platform. The procedure will be performed subsequently in the same segment of the opposite lung. Once the test is finished, the volume of BAL fluid that has been recovered will be measured.
Qualification for a specific type of ventilation (NIV or CPAP) will be carried out in a randomized manner by a specially created online platform. The procedure will be performed subsequently in the same segment of the opposite lung. Once the test is finished, the volume of BAL fluid that has been recovered will be measured.