The Efficacy of L-Carnitine in the Management of Acute Clozapine Intoxication
Clozapine Poisoning
About this trial
This is an interventional treatment trial for Clozapine Poisoning focused on measuring Clozapine Toxicity, Clozapine Poisoning, Clozapine Intoxication, L-Carnitine, Antioxidant, Egypt
Eligibility Criteria
Inclusion Criteria: The study will include patients with moderate and severe acute clozapine poisoning. The patient's condition will be assessed on admission using a Poisoning Severity Score. Exclusion criteria: When the diagnosis of acute clozapine poisoning is unconfirmed. Patients with significant comorbidities, especially advanced neurological and cardiac diseases. Patients that ingest other drugs other than clozapine. Patients who presented late to the poison center (>24 hr) following clozapine intake. Patients received treatment before hospital admission.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
Conventional Group
L-Carnitine Group
This group will comprise 20 patients who will receive conventional supportive care for the treatment of acute clozapine toxicity that include the following: Airway: maintaining clear patent airways. Breathing: oxygen inhalation, respiratory support whenever required (mechanical ventilation). Circulation: intravenous fluids, and symptomatic treatment according to ECG abnormalities. Decontamination: administration of activated charcoal (1 gm/kg).
This group will comprise 20 patients who will receive conventional supportive care (same as group 1), in addition to IV L-carnitine