Effect of Intraoperative Magnesium Sulphate on the Occurrence of Postoperative Delirium
Patients Undergoing Lumbar Fixation
About this trial
This is an interventional diagnostic trial for Patients Undergoing Lumbar Fixation
Eligibility Criteria
Inclusion Criteria: ASA I-II patients undergoing lumbar fixation. Male and female patients with age range between 20-70 years. Exclusion Criteria: Patients having gross hemodynamic or ventilatory fluctuations during the operation. Patients who develop postoperative shock, major bleeding or complication. Patients with a history of chronic pain that may interfere with sleep Patients with sleep apnea syndrome. Patient with a history of neurodegenerative disease, concomitant medical or metabolic illness known to affect sleep (e.g., thyroid, chest or cardiac disorders). Patients with a history of psychiatric disorders . Patients with a current history of illicit drug use. Patients using hypnotic, anxiolytic, or antipsychotic drugs . Allergy to any of the drugs that will be used in the study. Pregnancy.
Sites / Locations
- Beni-Suef UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Active Comparator
conventional anaesthesia group
Mg sulphate group
Induction of anesthesia will be done by injecting fentanyl 2 μg/kg, propofol1.5-2.5 mg/kg and atracurium 0.5 mg/kg for muscle relaxation.
Induction of anesthesia will be done by injecting fentanyl 2 μg/kg, propofol1.5-2.5 mg/kg and atracurium 0.5 mg/kg for muscle relaxation. With extra administration of intraoperative Magnesium sulphate 30 mg /kg as loading dose over 10 min then 10 mg /kg/ has maintenance dose