Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study
Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
About this trial
This is an interventional treatment trial for Recurrent Lung Non-Small Cell Carcinoma
Eligibility Criteria
Inclusion Criteria: Participants must have histologically or cytologically confirmed non-small cell lung cancer (NSCLC) which is stage IV or recurrent Participants must have received at least one line of anti-PD-1 or anti-PD-L1 therapy for any stage of NSCLC. Anti-PD-1 or anti-PD-L1 may have been given alone or in combination with other therapy Participants must have experienced disease progression (in the opinion of the treating physician) more than (>) 84 days following initiation (cycle 1 day 1) of their most recent anti-PD-1 or PD-L1 therapy Participants who received anti-PD-1 or anti-PD-L1 therapy for stage IV or recurrent disease, must have had a best response on anti-PD-1 or anti-PD-L1 therapy of stable, partial response or complete response (in the opinion of the treating physician) Participants who received neoadjuvant, adjuvant, and/or consolidation anti-PD-1 or anti-PD-L1 therapy as their only line of anti-PD-1 or anti-PD-L1 therapy must have experienced disease progression within (=<) 365 days from initiation (cycle 1 day 1) of anti-PD-1 or PD-L1 therapy Participants must have received platinum-based chemotherapy and experienced disease progression (in the opinion of the treating physician) during or after this regimen Participants with a known sensitizing mutation for which an Food and Drug Administration (FDA)-approved targeted therapy for NSCLC exists (e.g., EGFR, ALK, ROS1, BRAF, RET, NTRK, KRAS, HER2 and MET sensitizing mutations), must have previously received at least one of the approved therapy(s). Prior targeted therapy for participants with targetable alterations is allowed if all other eligibility criteria are also met Participants must be >= 18 years old Participants must be able to safely receive the investigational drug combination and the investigator's choice of standard of care regimens per the current FDA approved package insert(s), treating investigator's discretion, and institutional guidelines Participants must have Zubrod performance status of 0-2 Exclusion Criteria: Participants must not have received more than one line of anti-PD-1 or anti-PD-L1 for stage IV or recurrent disease Participants must not be receiving or planning to receive another investigational therapy during study participation
Sites / Locations
- University of Alabama at Birmingham Cancer CenterRecruiting
- Banner University Medical Center - TucsonRecruiting
- University of Arizona Cancer Center-North CampusRecruiting
- Highlands Oncology Group - Fayetteville
- John L McClellan Memorial Veterans HospitalRecruiting
- University of Arkansas for Medical SciencesRecruiting
- Highlands Oncology Group - RogersRecruiting
- Highlands Oncology GroupRecruiting
- Kaiser Permanente-AnaheimRecruiting
- PCR OncologyRecruiting
- Sutter Auburn Faith HospitalRecruiting
- Kaiser Permanente-Baldwin ParkRecruiting
- Kaiser Permanente-BellflowerRecruiting
- Alta Bates Summit Medical Center-Herrick CampusRecruiting
- Tower Cancer Research FoundationRecruiting
- Marshall Cancer CenterRecruiting
- City of Hope Comprehensive Cancer CenterRecruiting
- Kaiser Permanente DublinRecruiting
- Kaiser Permanente-FontanaRecruiting
- Kaiser Permanente-FremontRecruiting
- Palo Alto Medical Foundation-FremontRecruiting
- Kaiser Permanente - Harbor CityRecruiting
- City of Hope at Huntington BeachRecruiting
- City of Hope at Irvine LennarRecruiting
- Kaiser Permanente-IrvineRecruiting
- City of Hope Antelope ValleyRecruiting
- Loma Linda University Medical CenterRecruiting
- City of Hope at Long Beach ElmRecruiting
- Kaiser Permanente Los Angeles Medical CenterRecruiting
- Kaiser Permanente West Los AngelesRecruiting
- Cedars Sinai Medical CenterRecruiting
- Fremont - Rideout Cancer CenterRecruiting
- Memorial Medical CenterRecruiting
- Kaiser Permanente-ModestoRecruiting
- City of Hope Newport BeachRecruiting
- Kaiser Permanente-OaklandRecruiting
- Kaiser Permanente-OntarioRecruiting
- Palo Alto Medical Foundation Health CareRecruiting
- Kaiser Permanente - Panorama CityRecruiting
- Kaiser Permanente-RiversideRecruiting
- Kaiser Permanente-RosevilleRecruiting
- Sutter Roseville Medical CenterRecruiting
- Kaiser Permanente Downtown CommonsRecruiting
- Sutter Medical Center SacramentoRecruiting
- University of California Davis Comprehensive Cancer CenterRecruiting
- Kaiser Permanente-South SacramentoRecruiting
- Kaiser Permanente-San Diego ZionRecruiting
- California Pacific Medical Center-Pacific CampusRecruiting
- Kaiser Permanente-San FranciscoRecruiting
- Kaiser Permanente-Santa Teresa-San JoseRecruiting
- Kaiser Permanente San LeandroRecruiting
- Kaiser Permanente-San MarcosRecruiting
- Kaiser San Rafael-GallinasRecruiting
- Kaiser Permanente Medical Center - Santa ClaraRecruiting
- Palo Alto Medical Foundation-Santa CruzRecruiting
- Kaiser Permanente-Santa RosaRecruiting
- City of Hope South PasadenaRecruiting
- Kaiser Permanente-South San FranciscoRecruiting
- Palo Alto Medical Foundation-SunnyvaleRecruiting
- Torrance Memorial Physician Network - Cancer CareRecruiting
- Gene Upshaw Memorial Tahoe Forest Cancer CenterRecruiting
- City of Hope UplandRecruiting
- Kaiser Permanente-VallejoRecruiting
- Sutter Solano Medical Center/Cancer CenterRecruiting
- Kaiser Permanente-Walnut CreekRecruiting
- Kaiser Permanente-Woodland HillsRecruiting
- Rocky Mountain Regional VA Medical CenterRecruiting
- Kaiser Permanente-FranklinRecruiting
- Poudre Valley HospitalRecruiting
- Cancer Care and Hematology-Fort CollinsRecruiting
- UCHealth Greeley HospitalRecruiting
- Kaiser Permanente-Rock CreekRecruiting
- Kaiser Permanente-Lone TreeRecruiting
- Medical Center of the RockiesRecruiting
- Smilow Cancer Hospital-Derby Care CenterRecruiting
- Smilow Cancer Hospital Care Center-FairfieldRecruiting
- Smilow Cancer Hospital Care Center at GlastonburyRecruiting
- Smilow Cancer Hospital Care Center at GreenwichRecruiting
- Smilow Cancer Hospital Care Center - GuilfordRecruiting
- Smilow Cancer Hospital Care Center at Saint FrancisRecruiting
- Yale UniversityRecruiting
- Yale-New Haven Hospital North Haven Medical CenterRecruiting
- Smilow Cancer Hospital-Orange Care CenterRecruiting
- Smilow Cancer Hospital Care Center at Long RidgeRecruiting
- Stamford Hospital/Bennett Cancer CenterRecruiting
- Smilow Cancer Hospital-Torrington Care CenterRecruiting
- Smilow Cancer Hospital Care Center-TrumbullRecruiting
- Smilow Cancer Hospital-Waterbury Care CenterRecruiting
- Smilow Cancer Hospital Care Center - WaterfordRecruiting
- Beebe South Coastal Health CampusRecruiting
- Helen F Graham Cancer CenterRecruiting
- Medical Oncology Hematology Consultants PARecruiting
- Beebe Health CampusRecruiting
- Kaiser Permanente-Capitol Hill Medical CenterRecruiting
- Malcom Randall Veterans Administration Medical CenterRecruiting
- The Watson ClinicRecruiting
- Moffitt Cancer CenterRecruiting
- Northside HospitalRecruiting
- Northside Hospital - DuluthRecruiting
- Eisenhower Army Medical CenterRecruiting
- Northeast Georgia Medical Center-GainesvilleRecruiting
- Northside Hospital - GwinnettRecruiting
- Memorial Health University Medical CenterRecruiting
- Lewis Cancer and Research Pavilion at Saint Joseph's/CandlerRecruiting
- South Georgia Medical Center/Pearlman Cancer CenterRecruiting
- Pali Momi Medical CenterRecruiting
- Queen's Cancer Cenrer - POB IRecruiting
- Queen's Medical CenterRecruiting
- Queen's Cancer Center - KuakiniRecruiting
- Kaiser Permanente Moanalua Medical CenterRecruiting
- Saint Alphonsus Cancer Care Center-BoiseRecruiting
- Saint Luke's Cancer Institute - BoiseRecruiting
- Saint Alphonsus Cancer Care Center-CaldwellRecruiting
- Kootenai Health - Coeur d'AleneRecruiting
- Saint Luke's Cancer Institute - FruitlandRecruiting
- Saint Luke's Cancer Institute - MeridianRecruiting
- Saint Luke's Cancer Institute - NampaRecruiting
- Saint Alphonsus Cancer Care Center-NampaRecruiting
- Kootenai Clinic Cancer Services - Post FallsRecruiting
- Kootenai Cancer ClinicRecruiting
- Saint Luke's Cancer Institute - Twin FallsRecruiting
- Rush - Copley Medical CenterRecruiting
- Illinois CancerCare-BloomingtonRecruiting
- Illinois CancerCare-CantonRecruiting
- Illinois CancerCare-CarthageRecruiting
- Northwestern UniversityRecruiting
- Carle at The RiverfrontRecruiting
- Cancer Care Specialists of Illinois - DecaturRecruiting
- Decatur Memorial HospitalRecruiting
- Northwestern Medicine Cancer Center KishwaukeeRecruiting
- Illinois CancerCare-DixonRecruiting
- Carle Physician Group-EffinghamRecruiting
- Crossroads Cancer CenterRecruiting
- Illinois CancerCare-EurekaRecruiting
- Illinois CancerCare-GalesburgRecruiting
- Northwestern Medicine Cancer Center DelnorRecruiting
- Edward Hines Jr VA HospitalRecruiting
- Illinois CancerCare-Kewanee ClinicRecruiting
- Northwestern Medicine Lake Forest HospitalRecruiting
- Illinois CancerCare-MacombRecruiting
- Carle Physician Group-Mattoon/CharlestonRecruiting
- Loyola University Medical CenterRecruiting
- Cancer Care Center of O'FallonRecruiting
- Northwestern Medicine Orland ParkRecruiting
- Illinois CancerCare-Ottawa ClinicRecruiting
- Illinois CancerCare-PekinRecruiting
- Illinois CancerCare-PeoriaRecruiting
- Illinois CancerCare-PeruRecruiting
- Illinois CancerCare-PrincetonRecruiting
- Southern Illinois University School of MedicineRecruiting
- Springfield ClinicRecruiting
- Memorial Medical CenterRecruiting
- Carle Cancer CenterRecruiting
- Northwestern Medicine Cancer Center WarrenvilleRecruiting
- Illinois CancerCare - WashingtonRecruiting
- Rush-Copley Healthcare CenterRecruiting
- Memorial Hospital of South BendRecruiting
- Mercy HospitalRecruiting
- Oncology Associates at Mercy Medical CenterRecruiting
- Medical Oncology and Hematology Associates-Des MoinesRecruiting
- Mercy Medical Center - Des MoinesRecruiting
- HaysMed University of Kansas Health SystemRecruiting
- Lawrence Memorial HospitalRecruiting
- Olathe Health Cancer CenterRecruiting
- Salina Regional Health CenterRecruiting
- University of Kansas Health System Saint Francis CampusRecruiting
- King's Daughter's Medical CenterRecruiting
- University of Kentucky/Markey Cancer CenterRecruiting
- Owensboro Health Mitchell Memorial Cancer CenterRecruiting
- Louisiana Hematology Oncology Associates LLCRecruiting
- Mary Bird Perkins Cancer CenterRecruiting
- Terrebonne General Medical CenterRecruiting
- University Medical Center New OrleansRecruiting
- Sinai Hospital of BaltimoreRecruiting
- Kaiser Permanente-Woodlawn Medical CenterRecruiting
- UPMC Western MarylandRecruiting
- Kaiser Permanente-Gaithersburg Medical CenterRecruiting
- Kaiser Permanente - Largo Medical CenterRecruiting
- Kaiser Permanente Lutherville - Timonium Medical CenterRecruiting
- William E Kahlert Regional Cancer Center/Sinai HospitalRecruiting
- Beverly HospitalRecruiting
- Lahey Hospital and Medical CenterRecruiting
- Addison Gilbert HospitalRecruiting
- Lahey Medical Center-PeabodyRecruiting
- Baystate Medical CenterRecruiting
- Winchester HospitalRecruiting
- Saint Joseph Mercy HospitalRecruiting
- University of Michigan Comprehensive Cancer CenterRecruiting
- Bronson Battle CreekRecruiting
- Saint Joseph Mercy BrightonRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - BrightonRecruiting
- Saint Joseph Mercy CantonRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - CantonRecruiting
- Saint Joseph Mercy ChelseaRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalRecruiting
- Ascension Saint John HospitalRecruiting
- Great Lakes Cancer Management Specialists-Doctors ParkRecruiting
- Green Bay Oncology - EscanabaRecruiting
- Genesee Cancer and Blood Disease Treatment CenterRecruiting
- Genesee Hematology Oncology PCRecruiting
- Genesys Hurley Cancer InstituteRecruiting
- Hurley Medical CenterRecruiting
- Spectrum Health at Butterworth CampusRecruiting
- Great Lakes Cancer Management Specialists-Van Elslander Cancer CenterRecruiting
- Michigan Breast Specialists-Grosse Pointe Woods
- Bronson Methodist HospitalRecruiting
- West Michigan Cancer CenterRecruiting
- Ascension Borgess Cancer CenterRecruiting
- Borgess Medical CenterRecruiting
- Sparrow HospitalRecruiting
- Trinity Health Saint Mary Mercy Livonia HospitalRecruiting
- Great Lakes Cancer Management Specialists-Macomb Medical CampusRecruiting
- Michigan Breast Specialists-Macomb Township
- Trinity Health Muskegon HospitalRecruiting
- Cancer and Hematology Centers of Western Michigan - Norton ShoresRecruiting
- Lakeland Medical Center Saint JosephRecruiting
- Marie Yeager Cancer CenterRecruiting
- Bhadresh Nayak MD PC-Sterling HeightsRecruiting
- Munson Medical CenterRecruiting
- Advanced Breast Care Center PLLCRecruiting
- Great Lakes Cancer Management Specialists-Macomb Professional BuildingRecruiting
- Macomb Hematology Oncology PCRecruiting
- Michigan Breast Specialists-WarrenRecruiting
- Saint John Macomb-Oakland HospitalRecruiting
- University of Michigan Health - WestRecruiting
- Huron Gastroenterology PCRecruiting
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusRecruiting
- Sanford Joe Lueken Cancer CenterRecruiting
- Mercy HospitalRecruiting
- Fairview Southdale HospitalRecruiting
- Abbott-Northwestern HospitalRecruiting
- Park Nicollet Clinic - Saint Louis ParkRecruiting
- Regions HospitalRecruiting
- United HospitalRecruiting
- Baptist Memorial Hospital and Cancer Center-Golden TriangleRecruiting
- Baptist Cancer Center-GrenadaRecruiting
- Baptist Memorial Hospital and Cancer Center-Union CountyRecruiting
- Baptist Memorial Hospital and Cancer Center-OxfordRecruiting
- Baptist Memorial Hospital and Cancer Center-DesotoRecruiting
- Saint Francis Medical CenterRecruiting
- Parkland Health Center - FarmingtonRecruiting
- Truman Medical CentersRecruiting
- Saint Luke's Hospital of Kansas CityRecruiting
- Saint Luke's East - Lee's SummitRecruiting
- Missouri Baptist Medical CenterRecruiting
- Sainte Genevieve County Memorial HospitalRecruiting
- Mercy Hospital SpringfieldRecruiting
- Missouri Baptist Sullivan HospitalRecruiting
- Missouri Baptist Outpatient Center-Sunset HillsRecruiting
- Community Hospital of AnacondaRecruiting
- Billings Clinic Cancer CenterRecruiting
- Bozeman Deaconess HospitalRecruiting
- Benefis Healthcare- Sletten Cancer InstituteRecruiting
- Kalispell Regional Medical CenterRecruiting
- Community Medical HospitalRecruiting
- OptumCare Cancer Care at CharlestonRecruiting
- OptumCare Cancer Care at Fort ApacheRecruiting
- Renown Regional Medical CenterRecruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterRecruiting
- The Cancer Institute of New Jersey HamiltonRecruiting
- Monmouth Medical Center Southern CampusRecruiting
- Saint Barnabas Medical CenterRecruiting
- Monmouth Medical CenterRecruiting
- Virtua Samson Cancer CenterRecruiting
- Rutgers Cancer Institute of New JerseyRecruiting
- Robert Wood Johnson University Hospital SomersetRecruiting
- Community Medical CenterRecruiting
- Virtua VoorheesRecruiting
- University of New Mexico Cancer CenterRecruiting
- Montefiore Medical Center-Einstein CampusRecruiting
- Montefiore Medical Center-Weiler HospitalRecruiting
- Montefiore Medical Center - Moses CampusRecruiting
- Arnot Ogden Medical Center/Falck Cancer CenterRecruiting
- Garnet Health Medical CenterRecruiting
- Upstate Cancer Center at OneidaRecruiting
- Upstate Cancer Center at OswegoRecruiting
- University of RochesterRecruiting
- Stony Brook University Medical CenterRecruiting
- State University of New York Upstate Medical UniversityRecruiting
- SUNY Upstate Medical Center-Community CampusRecruiting
- Wilmot Cancer Institute at WebsterRecruiting
- Atrium Health Stanly/LCI-AlbemarleRecruiting
- AdventHealth Infusion Center AshevilleRecruiting
- Rex Hematology Oncology Associates-CaryRecruiting
- UNC Lineberger Comprehensive Cancer CenterRecruiting
- Carolinas Medical Center/Levine Cancer InstituteRecruiting
- Atrium Health Pineville/LCI-PinevilleRecruiting
- Levine Cancer Institute-SouthParkRecruiting
- Atrium Health University City/LCI-UniversityRecruiting
- Levine Cancer Institute-BallantyneRecruiting
- AdventHealth Infusion Center HaywoodRecruiting
- Atrium Health Cabarrus/LCI-ConcordRecruiting
- Levine Cancer Institute - RutherfordRecruiting
- Rex Hematology Oncology Associates-GarnerRecruiting
- Levine Cancer Institute-GastonRecruiting
- AdventHealth HendersonvilleRecruiting
- Atrium Health Lincoln/LCI-LincolntonRecruiting
- Levine Cancer Institute - Union WestRecruiting
- Atrium Health Union/LCI-UnionRecruiting
- FirstHealth of the Carolinas-Moore Regional HospitalRecruiting
- UNC Rex HealthcareRecruiting
- UNC Rex Cancer Center of WakefieldRecruiting
- Atrium Health Cleveland/LCI-ClevelandRecruiting
- AdventHealth Infusion Center WeavervilleRecruiting
- Sanford Bismarck Medical CenterRecruiting
- Sanford Broadway Medical CenterRecruiting
- Sanford Roger Maris Cancer CenterRecruiting
- Summa Health System - Akron CampusRecruiting
- Cleveland Clinic Akron GeneralRecruiting
- Summa Health System - Barberton CampusRecruiting
- Strecker Cancer Center-BelpreRecruiting
- Cleveland Clinic Mercy HospitalRecruiting
- Aultman Health FoundationRecruiting
- Miami Valley Hospital SouthRecruiting
- Adena Regional Medical CenterRecruiting
- Cleveland Clinic Cancer Center/Fairview HospitalRecruiting
- Cleveland Clinic FoundationRecruiting
- Mount Carmel East HospitalRecruiting
- The Mark H Zangmeister CenterRecruiting
- Dayton Blood and Cancer CenterRecruiting
- Miami Valley HospitalRecruiting
- Dayton Physician LLC-Miami Valley Hospital NorthRecruiting
- Miami Valley Hospital NorthRecruiting
- Atrium Medical Center-Middletown Regional HospitalRecruiting
- Kettering Medical CenterRecruiting
- Fairfield Medical CenterRecruiting
- Cleveland Clinic Cancer Center MansfieldRecruiting
- Hillcrest Hospital Cancer CenterRecruiting
- Summa Health Medina Medical CenterRecruiting
- Knox Community HospitalRecruiting
- Licking Memorial HospitalRecruiting
- Mercy Health Perrysburg Cancer CenterRecruiting
- Southern Ohio Medical CenterRecruiting
- North Coast Cancer CareRecruiting
- Springfield Regional Cancer CenterRecruiting
- Springfield Regional Medical CenterRecruiting
- Trinity's Tony Teramana Cancer CenterRecruiting
- Cleveland Clinic Cancer Center StrongsvilleRecruiting
- Mercy Health - Saint Anne HospitalRecruiting
- Toledo Clinic Cancer Centers-ToledoRecruiting
- Upper Valley Medical CenterRecruiting
- South Pointe HospitalRecruiting
- Saint Ann's HospitalRecruiting
- Cleveland Clinic Wooster Family Health and Surgery CenterRecruiting
- Genesis Healthcare System Cancer Care CenterRecruiting
- University of Oklahoma Health Sciences CenterRecruiting
- Legacy Mount Hood Medical CenterRecruiting
- Providence Newberg Medical CenterRecruiting
- Saint Alphonsus Medical Center-OntarioRecruiting
- Providence Willamette Falls Medical CenterRecruiting
- Legacy Good Samaritan Hospital and Medical CenterRecruiting
- Providence Portland Medical CenterRecruiting
- Providence Saint Vincent Medical CenterRecruiting
- Kaiser Permanente NorthwestRecruiting
- Legacy Meridian Park HospitalRecruiting
- Lehigh Valley Hospital-Cedar CrestRecruiting
- UPMC AltoonaRecruiting
- UPMC-Heritage Valley Health System BeaverRecruiting
- Lehigh Valley Hospital - MuhlenbergRecruiting
- Bryn Mawr HospitalRecruiting
- UPMC Hillman Cancer Center at Butler Health SystemRecruiting
- UPMC Camp HillRecruiting
- Carlisle Regional Cancer CenterRecruiting
- WellSpan Medical Oncology and HematologyRecruiting
- Pocono Medical CenterRecruiting
- Ephrata Cancer CenterRecruiting
- UPMC Hillman Cancer Center ErieRecruiting
- UPMC Cancer Center at UPMC HorizonRecruiting
- Adams Cancer CenterRecruiting
- UPMC Cancer Centers - Arnold Palmer PavilionRecruiting
- UPMC Pinnacle Cancer Center/Community Osteopathic CampusRecruiting
- IRMC Cancer CenterRecruiting
- UPMC-Johnstown/John P. Murtha Regional Cancer CenterRecruiting
- Sechler Family Cancer CenterRecruiting
- UPMC Cancer Center at UPMC McKeesportRecruiting
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer PavilionRecruiting
- Riddle Memorial HospitalRecruiting
- UPMC Hillman Cancer Center - MonroevilleRecruiting
- UPMC Hillman Cancer Center - Part of Frick HospitalRecruiting
- Arnold Palmer Cancer Center Medical Oncology NorwinRecruiting
- UPMC Cancer Center-Natrona HeightsRecruiting
- UPMC Hillman Cancer Center - New CastleRecruiting
- Paoli Memorial HospitalRecruiting
- Thomas Jefferson University HospitalRecruiting
- Jefferson Torresdale HospitalRecruiting
- UPMC-Saint MargaretRecruiting
- UPMC-Mercy HospitalRecruiting
- University of Pittsburgh Cancer Institute (UPCI)Recruiting
- UPMC-Passavant HospitalRecruiting
- UPMC-Saint Clair Hospital Cancer CenterRecruiting
- UPMC Cancer Center at UPMC NorthwestRecruiting
- UPMC Cancer Center-UniontownRecruiting
- UPMC Cancer Center-WashingtonRecruiting
- Divine Providence HospitalRecruiting
- Asplundh Cancer PavilionRecruiting
- Lankenau Medical CenterRecruiting
- WellSpan Health-York Cancer CenterRecruiting
- UPMC MemorialRecruiting
- Smilow Cancer Hospital Care Center - WesterlyRecruiting
- AnMed Health Cancer CenterRecruiting
- Saint Joseph's/Candler - Bluffton CampusRecruiting
- Medical University of South CarolinaRecruiting
- McLeod Regional Medical CenterRecruiting
- Tidelands Georgetown Memorial HospitalRecruiting
- Gibbs Cancer Center-PelhamRecruiting
- South Carolina Cancer Specialists PCRecruiting
- Levine Cancer Institute-Rock HillRecruiting
- Spartanburg Medical CenterRecruiting
- Sanford Cancer Center Oncology ClinicRecruiting
- Sanford USD Medical Center - Sioux FallsRecruiting
- Baptist Memorial Hospital and Cancer Center-ColliervilleRecruiting
- Baptist Memorial Hospital and Cancer Center-MemphisRecruiting
- The Don and Sybil Harrington Cancer CenterRecruiting
- Norris Cotton Cancer Center-NorthRecruiting
- University of Virginia Cancer CenterRecruiting
- Kaiser Permanente Tysons Corner Medical CenterRecruiting
- PeaceHealth Saint Joseph Medical CenterRecruiting
- PeaceHealth United General Medical CenterRecruiting
- Legacy Cancer Institute Medical Oncology and Day TreatmentRecruiting
- Legacy Salmon Creek HospitalRecruiting
- West Virginia University Charleston DivisionRecruiting
- Edwards Comprehensive Cancer CenterRecruiting
- West Virginia University HealthcareRecruiting
- Langlade Hospital and Cancer CenterRecruiting
- ThedaCare Regional Cancer CenterRecruiting
- HSHS Sacred Heart HospitalRecruiting
- Saint Vincent Hospital Cancer Center Green BayRecruiting
- Saint Vincent Hospital Cancer Center at Saint Mary'sRecruiting
- Gundersen Lutheran Medical CenterRecruiting
- University of Wisconsin Carbone Cancer CenterRecruiting
- Aspirus Medford HospitalRecruiting
- ProHealth D N Greenwald CenterRecruiting
- ProHealth Oconomowoc Memorial HospitalRecruiting
- Saint Vincent Hospital Cancer Center at Oconto FallsRecruiting
- Saint Vincent Hospital Cancer Center at SheboyganRecruiting
- Ascension Saint Michael's HospitalRecruiting
- Saint Vincent Hospital Cancer Center at Sturgeon BayRecruiting
- ProHealth Waukesha Memorial HospitalRecruiting
- UW Cancer Center at ProHealth CareRecruiting
- Aspirus Regional Cancer CenterRecruiting
- Aspirus Cancer Care - Wisconsin RapidsRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
ARM A (standard of care chemotherapy)
ARM B (ramucirumab, pembrolizumab)
Patients receive chemotherapy per standard of care on study.
Patients receive ramucirumab IV and pembrolizumab IV on study.