Effectiveness of Anisodamine Hydrobromide Combined With Heparin for the Treatment of Critically Ill Patients With Septic Shock
Septic Shock
About this trial
This is an interventional treatment trial for Septic Shock
Eligibility Criteria
Inclusion Criteria: Patients with septic shock Exclusion Criteria: The age of <18 years or >80 years; Patients who were expected to die within 24h before enrollment; Patients who died or withdrew from the experiment due to serious diseases of heart, liver, kidney and other organs or mental diseases before reaching the end of the intervention effect; Patients had received treatment related to septic shock before enrollment, which may affect the observers of effect indicators; patients contraindicated with heparin and anisodamine; Refuse to sign the informed consent; Patients with thrombotic diseases requiring low molecular weight heparin treatment.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
No Intervention
anisodamine hydrobromide
heparin
Anisodamine hydrobromide combined with heparin
conventional therapy
The dosage of anisodamine hydrobromide is 1.2-4.0mg/ (kg·d) according to the condition, and the micropump will be used at constant speed. After circulation stabilization and withdrawal of vasoactive drugs, the dosage will be reduced and gradually discontinued.
The dosage of heparin is determined by the condition, 3000-6000U subcutaneous injection once a day; After circulation stabilization and withdrawal of vasoactive drugs, the dosage will be reduced and gradually discontinued.
The dosage of anisodamine hydrobromide is 1.2-4.0mg/(kg·d) according to the condition, and the micropump will be used at constant speed. The dosage of heparin, depending on the condition, is 3000-6000U subcutaneous injection once a day; After circulation stabilization and withdrawal of vasoactive drugs, the dosage will be reduced and gradually discontinued.
Conventional treatment includes antishock therapy, elimination of the cause, active treatment of the primary disease, replenishing blood volume, correcting acid-base imbalance, blood pressure maintenance with vasoactive drugs, and advanced life support, including advanced organ support such as ventilators and bedside hemofiltration, when the condition requires it.