NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI (NO AD)
Spinal Cord Injuries, Autonomic Dysreflexia
About this trial
This is an interventional supportive care trial for Spinal Cord Injuries focused on measuring spinal cord injury, autonomic dysreflexia, blood pressure, bowel care management, defecation
Eligibility Criteria
Inclusion Criteria: participants must have had a traumatic spinal cord injury at least one year ago regular bowel care routine can communicate in English Exclusion Criteria: cauda equina or conus lesions currently use ventilator colostomy, or do not perform regular bowel care skin breakdown (pressure sores) cannot communicate in English under 19 years old possibly or certainly pregnant medical/psychiatric condition or substance abuse that is likely to affect ability to complete study currently using medications containing PDE-5 inhibitors currently using medications containing GTN allergy to GTN
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Glyceryl trinitrate sublingual spray
Placebo sublingual spray
Glyceryl trinitrate (GTN) sublingual spray will be administered up to three times every fifteen minutes, each dose being 0.4mg.
An approximate flavour-matched placebo sublingual spray will be administered up to three times every fifteen minutes.