Evaluation of Sonelokimab for the Treatment of Patients With Active Psoriatic Arthritis
Arthritis, Psoriatic
About this trial
This is an interventional treatment trial for Arthritis, Psoriatic focused on measuring Arthritis, Psoriatic, Skin Diseases, Joint Diseases, Arthritis, Psoriasis
Eligibility Criteria
Inclusion Criteria: Participant is ≥18 years of age; Participant has a confirmed diagnosis of PsA per the 2006 Classification criteria for Psoriatic Arthritis (CASPAR) with symptoms for ≥6 months prior to the Screening Visit; Participant has active disease (defined by a TJC68 of ≥3 and a SJC66 of ≥3); Participant has either current active PsO or a dermatologist confirmed history of PsO; Participant tests negative for rheumatoid factor (RF) at the Screening Visit; Participant tests negative for anti-cyclic citrullinated peptide (CCP) antibodies at the Screening Visit; Participant must be, in the opinion of the investigator, a suitable candidate for treatment with adalimumab per approved local product information. Exclusion Criteria: Participant with known hypersensitivity to sonelokimab or any of its excipients; Participant with known hypersensitivity to adalimumab or any of its excipients; Participant who has previously failed on anti-interleukin (IL)-17 therapy; Participant who has previously failed on anti-tumor necrosis factor alpha (TNFα) therapy; Participant who has had previous exposure to more than 2 biologic agents of any type to treat PsA prior to the Screening Visit; Participant who has a diagnosis of chronic inflammatory conditions other than PsO or PsA; Participant who has a diagnosis of arthritis mutilans
Sites / Locations
- Clinical Site
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- Clinical SIte
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Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Placebo Comparator
Active Comparator
sonelokimab dose regimen 1
sonelokimab dose regimen 2
sonelokimab dose regimen 3
Placebo
adalimumab
Subjects randomized to this arm will receive assigned sonelokimab dosage regimen 1
Subjects randomized to this arm will receive assigned sonelokimab dosage regimen 2
Subjects randomized to this arm will receive assigned sonelokimab dosage regimen 3
Subjects randomized to this arm will receive placebo
Subjects randomized to this arm will receive adalimumab