Inflammation During ECMO Therapy and ECMO Weaning (ECMOWean)
Acute Respiratory Distress Syndrome
About this trial
This is an interventional treatment trial for Acute Respiratory Distress Syndrome focused on measuring Acute Respiratory Distress Syndrome, Extracorporal membrane oxygenation, Extracorporal membrane oxygenation weaning, Ventilation therapy
Eligibility Criteria
Inclusion Criteria: Acute respiratory distress syndrome (ARDS) according to the Berlin Definition (PaO2/FiO2 < 100) and treatment with veno-venous ECMO (vvECMO) Hemodynamic stability Lung compliance did not change/improved during the last 24 hours Tidal volume did not change/improved during the last 24 hours with a PEEP of 10 cmH20 or above Consent of the patient or their legal representative Exclusion Criteria: Age < 18 years Artificial ventilation for more than 7 days prior Patient, legal representative or doctors decided against an unrestricted intensive care treatment Positive pregnancy test at time of screening Cardiac failure requiring veno-arterial ECMO therapy Chronic respiratory insufficiency requiring long-term oxygen treatment
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Ventilator weaning first
ECMO weaning first