68Ga/177Lu-PSMA Theranostics in Recurrent Grade 3 and Grade 4 Glioma

Inclusion Criteria: A previous diagnosis of histologically confirmed WHO grade 3 or grade 4 glioma Radiologically (MRI) confirmed tumor relapse/progression ≥ 12 weeks since completed radiotherapy or suspicion of recurrence where inclusion in the theranostic part of study could be indicated Must be ≥ 18 years old Written informed consent for study participation Negative pregnancy test no longer than 14 days prior to enrollment Life expectancy > 12 weeks Karnofsky performance status ≥ 70% (must be able to care for self after radionuclide therapy) High tumor uptake on diagnostic imaging with 68Ga -PSMA. Tumor not amendable for radiotherapy or surgery, and treating oncologist think that there are no other preferable systemic therapy options (e.g temozolomide, PCV or lomustine monotherapy). Women of childbearing potential (WOCBP) defined as fertile, following menarche and until becoming post-menopausal unless permanently sterile must use adequate contraception. Permanent sterilization methods include hysterectomy, bilateral salpingectomy or bilateral oophorectomy. Adequate contraception in the current study will be the following: o Combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation: Intravaginal transdermal Progestogen-only hormonal contraception associated with inhibition of ovulation: oral injectable implantable intrauterine device (IUD) intrauterine hormone-releasing system ( IUS) bilateral tubal occlusion vasectomised partner sexual abstinence Patient accept not to receive any other tumor directed treatment before 8 weeks after each 177Lu-PSMA injection. Exclusion Criteria: Estimated GFR < 30 mL/min Platelet count <75 x109 /L White blood cells ≤ 2.5 x 109/L Neutrophil count < 1.5 x109 /L Hb < 8.0 g/dL Albumin ≤ 25 g/L Uncontrollable symptomatic epilepsy refractory to standard medication Pacemakers or defibrillators not compatible with 3T MRI No ability to obtain informed consent (e.g. due to severe dysphasia or cognitive deficits). Breastfeeding Pregnancy Hypersensitivity to the active substance or to any of the excipients Urinary and fecal incontinence (patient cannot have diaper needs) Significant medical or psychiatric illness that, in the investigator's opinion, would compromise the patient's ability to tolerate this therapy If previous radiotherapy and/or radionuclide therapy have resulted in absorbed doses >=23 Gy to any of the kidneys, or >= 25 Gy to any of the parotids, an individual assessment will be made by the nuclear medicine physician and medical physicist if patient can be included to the therapy part of the study. Concurrent investigational drugs or experimental therapy must be stopped at least 4 weeks prior to study entry Unwilling to accept potential challenge with xerostomia