Optimization of Prime Fluid Strategy to Preserve Microcirculatory Perfusion During Cardiac Surgery With Cardiopulmonary Bypass, Part I (PRIME part I)
Endothelial Dysfunction, Hemolysis, Fluid Overload
About this trial
This is an interventional treatment trial for Endothelial Dysfunction focused on measuring Microcirculation, Cardiopulmonary bypass, Colloid oncotic pressure, Hemodilution, Hemolysis
Eligibility Criteria
Inclusion Criteria: Adult subjects Informed consent Elective coronary artery bypass surgery with cardiopulmonary bypass Exclusion Criteria: Emergency operations Re-operation Elective thoracic aortic surgery Elective valve surgery Combined procedure CABG and valve surgery Known allergy for human albumin or gelofusine
Sites / Locations
- Amsterdam UMC, AMC locationRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Active Comparator
A: gelofusine + ringers
B: albumin + ringers
C: ringers + retrograde autologous priming
Prime fluid strategy containing gelofusine and ringers
Prime fluid strategy containing albumin and ringers
Prime fluid strategy containing ringers combined with retrograde autologous priming