NIV-FOB, HFNC-FOB- Comparison of Methods (NIRA)
Respiratory Failure, Hypoxemia, Hypoxemic Respiratory Failure
About this trial
This is an interventional prevention trial for Respiratory Failure focused on measuring respiratory failure, non invasive ventilation, bronchofiberoscopy
Eligibility Criteria
Inclusion Criteria: Patient ≥ 18 years, with indications for bronchoscopy, Diagnostic procedure: lung cancer, hemoptysis, BAL in interstitial lung diseases. Therapeutic procedure: pneumonia in patients with impaired cough reflex, performed to obtain sputum cultures and bronchial tree toilet, hemoptysis or foreign body aspiration in patients not requiring rigid bronchoscopic management. Written informed consent to participate in the study, PO2/fiO2≤300 in blood gas test performed directly (within 24 h) during the qualification for FB Exclusion Criteria: No willingness to participate, PO2/fiO2>300 in arterial blood gases, severe unstable coronary artery disease (CCS III/IV), NYHA III/IV, Hemodynamic instability defined as continuous amine influx. Myocardial infarction during the last 2 weeks, without PCI treatment. Unstable angina, severe arrhythmias - especially ventricular, Chronic primary pulmonary hypertension confirmed by right heart catherisation in WHO III/IV, Unsecured by chest tube pneumothorax, Platelet count <20,000 /µl (without platelet transfusion), INR >2 or APTT >36 s., in case of diagnostic FB [18] The study will also not include patients who were intubated before randomization.
Sites / Locations
- Aleksandra
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
x≤300 HFNO or standard oxygen supplementation
100<x≤200 NIV or HFNO
x≤100 NIV or intubation
bronchoscopy, taking blood gas, taking blood for blood test
bronchoscopy, taking blood gas, taking blood for blood test
bronchoscopy, taking blood gas, taking blood for blood test, intubation