Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients (CogRT)
Brain Tumor, Head and Neck Cancer
About this trial
This is an interventional treatment trial for Brain Tumor focused on measuring radiation therapy, pediatric
Eligibility Criteria
STRATUM A Eligibility Criteria aged 1 to <26 years of age tumor must be located in the brain or adjacent to the brain including but not limited to nasopharynx, paranasal sinuses and orbit treatment must include radiation therapy (either proton or photon) patients must not have completed radiation therapy Exclusion Criteria pregnancy patients who are not able to undergo neuro-cognitive testing, including children lacking English comprehension or children with premorbid neurological/neurodevelopmental disorders such as Down's syndrome or autism STRATUM B Eligibility Criteria diagnosed with a brain tumor at <26 years of age received radiation to the brain as part of therapy time from radiation start to study enrollment is ≥ 2 years there has not been disease recurrence from time of most recent radiation treatment to study enrollment Exclusion Criteria patients who are not able to undergo neuro-cognitive testing, including children lacking English comprehension or children with premorbid neurological/neurodevelopmental disorders such as Down's syndrome or autism STRATUM C Eligibility Criteria must be aged 5 to <26 years of age must be able to complete research imaging without sedation Exclusion Criteria must not have any major psychiatric, neurologic or medical diagnosis
Sites / Locations
- Sibley Memorial HospitalRecruiting
- Johns Hopkins HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Other
Other
Stratum A (new diagnosis, substructure informed radiation therapy)
Stratum B (patients ≥ 2 years after standard radiation therapy)
Stratum C (healthy controls matched to Stratum A)
Patients will undergo radiation therapy which has been planned according to dose constraints to specific brain substructures.
Patients who completed radiation therapy under standard planning procedures ≥ 2 years ago.
Healthy patients who are matched to Stratum A patients