Studying Language With Brain Stimulation in Aphasia
Stroke, Aphasia
About this trial
This is an interventional treatment trial for Stroke focused on measuring Transcranial Magnetic Stimulation, Stroke Aphasia, Language, Functional Magnetic Resonance Imaging
Eligibility Criteria
Inclusion Criteria: Diagnosis of non-fluent aphasia due to a single, left-hemisphere stroke ≧ six months post-stroke onset WAB-R Fluency, Grammatical Competence, and Paraphasias Score between 2-6 18+ years of age Premorbidly right-handed English-speaking Ability to participate in fMRI / TMS protocol Exclusion Criteria: Cardiac pacemaker or pacemaker wires; neurostimulators; implanted pumps Metal in the body (rods, plates, screws, shrapnel, dentures, IUD) or metallic particles in the eye Surgical clips in the head or previous neurosurgery Any magnetic particles in the body Cochlear implants Prosthetic heart valves Epilepsy or any other type of seizure history History of significant head trauma (i.e., extended loss of consciousness, neurological sequelae) Significant other disease (heart disease, malignant tumors, mental disorders) Significant claustrophobia Ménière's disease Medications that increase risk of seizures, for instance antipsychotic and antidepressant medications acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants Non-prescribed drug use, for instance recreational marijuana Unable to refrain from using any alcohol and nicotine products for at least 24 hours before the study Visits.
Sites / Locations
- Shirley Ryan AbilityLabRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
ccPAS group
Sham ccPAS group
Patients under this group will receive ccPAS followed by speech-language therapy.
Patients under this group will receive sham ccPAS followed by speech-language therapy.