A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Liver Problems
Hepatic Insufficiency
About this trial
This is an interventional treatment trial for Hepatic Insufficiency
Eligibility Criteria
Inclusion criteria applicable to all participants Male or female participants Age 18-79 years (inclusive) Body Mass Index (BMI) of 18.5 to 35 kilogram per square meter (kg/m2) (inclusive) Signed and dated written informed consent in accordance with Guideline for Guideline for Good Clinical Practice - Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial Male participants are not required to use contraception Women of childbearing potential are allowed to participate provided they use a highly effective contraception from at least 30 days before the administration of trial medication until 7 days after trial completion. Of note, oral hormonal contraceptives are not considered as highly effective in this study due to the potential CYP3A induction by BI 1015550. Therefore, the following methods of contraception are considered adequate for female participants of childbearing potential: Use of combined (oestrogen and progestogen containing) hormonal contraception that prevents ovulation (oral, intravaginal or transdermal), plus condom Use of progestogen-only hormonal contraception that inhibits ovulation (only injectables or implants), plus condom Use of intrauterine device or intrauterine hormone-releasing system Sexually abstinent A vasectomised sexual partner who received medical assessment of the surgical success (documented absence of sperm) and provided that partner is the sole sexual partner of the trial participant. Female participants are not considered to be of childbearing potential if they are either surgically sterilised (including hysterectomy) or postmenopausal, defined as no menses for 1 year without an alternative medical cause (in questionable cases a blood sample with levels of Follicle stimulating hormone (FSH) above 40 Units per litre (U/L) and oestradiol below 30 nanogram per litre (ng/L) is confirmatory) Inclusion criteria applying only to participants with impaired hepatic function Hepatic impairment classified as Child-Pugh A (score 5-6 points) or Child-Pugh B (score 7-9 points) further inclusion criteria apply Inclusion criteria applying only to participants with normal hepatic function Individually matched to participants with hepatic impairment according to sex, age, and weight further inclusion criteria apply Exclusion criteria applying to all participants Any evidence of a concomitant disease assessed as clinically relevant by the investigator Cholecystectomy or other surgery of the gastrointestinal tract that could interfere with the pharmacokinetic(s) (PK) of the trial medication (except appendectomy or simple hernia repair) Diseases of the central nervous system (CNS) (including but not limited to any kind of seizures or stroke), and other relevant neurological or psychiatric disorders (including but not limited to major depressive disorder) History of relevant orthostatic hypotension, fainting spells, or blackouts Relevant chronic or acute infections Any documented active or suspected malignancy or history of malignancy within 5 years prior to screening, except appropriately treated basal cell carcinoma of the skin or squamous cell carcinoma in situ of the skin or in situ carcinoma of uterine cervix further exclusion criteria apply Exclusion criteria applying only to participants with hepatic impairment A marked prolongation of time from the start of the Q wave to the end of the T wave (QT)/ QT corrected for heart rate (QTc) interval (such as QT Corrected by the Fridericia Formula (QTcF) intervals that are repeatedly greater than 480 milliseconds (ms) in males or repeatedly greater than 500 ms in females) or any other relevant Electrocardiogram (ECG) finding at screening further exclusion criteria apply Exclusion criteria applying only to participants with normal hepatic function Any finding in the medical examination (including blood pressure (BP), pulse rate (PR) or ECG) deviating from normal and assessed as clinically relevant by the investigator further exclusion criteria apply
Sites / Locations
- CRS Clinical Research Services Kiel GmbH
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Group 1: participants with mild hepatic impairment (Child-Pugh A)
Group 2: participants with moderate hepatic impairment (Child-Pugh B)
Group 3: participants with normal hepatic function individually matched to participants of Group 1
Group 4: participants with normal hepatic function individually matched to participants of Group 2
One participant with normal hepatic function may match one participant in one or both groups of participants with hepatic impairment. The matching criteria of the participants with normal hepatic function to the participants with hepatic impairment: Age (± 10 years) Gender Weight (± 15%)
One participant with normal hepatic function may match one participant in one or both groups of participants with hepatic impairment. The matching criteria of the participants with normal hepatic function to the participants with hepatic impairment: Age (± 10 years) Gender Weight (± 15%)