Catheter Guided Chemo-infusion in Breast Cancer
Breast Cancer
About this trial
This is an interventional treatment trial for Breast Cancer focused on measuring breast cancer, chemotherapy
Eligibility Criteria
Inclusion Criteria: Adult female had stage III,IV breast cancer. Female had received no prior chemotherapy, radiotherapy, or definitive surgical therapy for breast cancer. Patient had adequate organ function. Exclusion Criteria: Patients known to have absolute contraindications for contrast. Patient known to have systemic organ failure.
Sites / Locations
Arms of the Study
Arm 1
Experimental
Advanced breast cancer patients
Tumors are staged according to the criteria of the Union for International Cancer Control (UICC). Tumor volume was determined by mammography or magnetic resonance imaging (MRI). Patients will be cannulated via the femoral artery. Then, a 4F fixed-curve catheter (Cobra catheter, Cook Corporation, Bloomington) was advanced to the ipsilateral subclavian artery. Digital subtraction angiography (DSA) was performed to determine tumor arterial blood supply. Super selection of the internal mammary artery done by micro-catheter. Chemo-infusion was decided by the major feeding artery. The intra-arterial chemoinfusion regimen consisted of docetaxel 75 mg/m2 and epirubicin 50 mg/m2 in 200 mL of normal saline and 5% glucose; the drugs were slowly infused via the catheter over at least 15 minutes. Intraarterial infusion was performed once every 3 weeks on average.