Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp
Intracanal Medication, N-acetylcystine, Calcium Hydroxide
About this trial
This is an interventional treatment trial for Intracanal Medication
Eligibility Criteria
Inclusion Criteria: Patients who are free from any physical or mental handicapping condition. Males & Females with Mandibular single rooted permanent premolar teeth. Absence of spontaneous pain. Slight widening in the periodontal membrane space or with periapical radiolucency not exceeding 2*2 mm radiographically. Patients' acceptance to participate in the trial. Patients who can understand pain scale and can sign the informed consent (Appendix I) Exclusion Criteria: Medically compromised patients. Pregnant women Patients undergoing previous endodontic treatment or analgesics and/or antibiotics have been administrated by the patient during the past 24 hours preoperatively. Patients reporting bruxism or clenching. Teeth that show association with acute periapical abscess and swelling. Greater than grade I mobility or pocket depth greater than 5mm. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam Teeth with vital pulp. Immature teeth. Radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.
Sites / Locations
- FACULTY OF DENTISTRY-cairo university
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
N-acetylcysteine
Calcium hydroxide
intracanal medication of NAC paste
intracanal medication of Ca(OH)2 paste