lIfestyle iNterventionS for PaIn ReliEf (INSPIRE) (INSPIRE)
Osteoarthritis, Knee
About this trial
This is an interventional basic science trial for Osteoarthritis, Knee
Eligibility Criteria
Inclusion Criteria: Participant is willing and able to give informed consent for participation in the study Participant eligibility includes those aged >18 years who have a body mass index (BMI) between 18.5 and 39.9 kg/m2 Exclusion Criteria: The participant may not enter the study if ANY of the following apply: Have psychosocial or gastrointestinal (e.g. malabsorptive conditions such as IBS/IBD, coeliac) Are taking the following medications: immunosuppressants, anticoagulants, amiodarone and/or perhexiline Are currently following or anticipated to commence a specialised commercially available weight loss diet and/or program Pregnant or breast feeding History or current psychiatric illness History or current neurological condition (e.g. epilepsy) Those undergoing revision, having severe hip OA, inflammatory arthropathies Diagnosed non-OA cause of knee pain (e.g. rheumatoid arthritis) Neuropathy or diabetes mellitus Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance (this must remain for ALL UoN FMHS UREC approved studies)
Sites / Locations
- University of NottinghamRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Placebo Comparator
Experimental
Experimental
Experimental
Placebo arm
Diet only Arm
Exercise only arm
Diet + exercise intervention arm
The participants in the placebo/control arm (N=30) will be required to take 10g of maltodextrin for the same period of 6 weeks.
The participants in the dietary intervention arm will be required to take 20g of inulin (N=30) for a period of 6 weeks.
Joint Academy An app-based exercises platform (Joint Academy®) will be used as an intervention given to the treatment arm. The programme consists of a mixture of open and close chain exercises, a combination of concentric, eccentric and focusing on the global strength of legs including the muscles around the hips and knee joints as well as balance enhancement exercises. The intervention also includes educational sessions integrated into the programme covering the basics of OA, its treatment, self-managing symptoms of OA and the benefits of maintaining a healthy lifestyle. The exercise intervention focuses on core stability and performance, neuromuscular leg strengthening and balance enhancement.
The participants in this arm will be required to take 20g of inulin (N=30) for a period of 6 weeks and doing exercise at the same time.