Transcranial Magnetic Stimulation in Disorder of Consciousness in Acute Severe Cerebrovascular Disease Patients (I-HELP)
Ischemic Stroke, Consciousness Disorder, Transcranial Magnetic Stimulation
About this trial
This is an interventional treatment trial for Ischemic Stroke focused on measuring Ischemic Stroke, Consciousness Disorder, Transcranial Magnetic Stimulation, Hybrid Neural Network Evaluation Model
Eligibility Criteria
Inclusion Criteria: 7-28 days after ischemic stroke behavioral profile consistent with a UWS or MCS as assessed with the Coma Recovery Scale Revise prestroke Modified Ranking Scale(mRS) ≤2 Exclusion Criteria: history of vascular malformation or aneurysmal SAH or untreated aneurysm prior to stroke disorder of consciousness prior to stroke impairment of hearing metal implants, e.g. stenting, pacemaker, etc. contraindications to MRI, such as claustrophobia history of epilepsy or epileptic episodes suffering from serious diseases such as malignant tumors, etc., with expected survival time <1 year patient is currently involved with other trials
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
rTMS treatment
iTBS treatment
20 days of repetitive transcranial magnetic stimulation: stimulation site is the left dorsolateral prefrontal cortex, stimulation intensity at 90% RMT, stimulation frequency is 10Hz. A total of 1000 pulses, 10s 10Hz train stimulation, repeated 10 times, each interval 60s, a total of 11 minutes and 40 seconds, 1 treatment per day, a total of 20 days.
20 days of intermittent theta-burst stimulation: stimulation site is the left dorsolateral prefrontal cortex, stimulation intensity at 90% RMT, stimulation frequency is 50Hz. A total of 600 pulses, 3 pulses each time, with an interval of 200 ms, for a total of 2 seconds (10 groups), and then repeat the above process after an interval of 10 seconds, a total of 190 seconds, 1 treatment per day, a total of 20 days.