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ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors (PRESERVE-003)

Primary Purpose

Non Small Cell Lung Cancer

Status
Recruiting
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Gotistobart
Docetaxel
Sponsored by
OncoC4, Inc.
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Non Small Cell Lung Cancer

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria (Major criteria): Adult (≥ 18 years), all genders, capable of signing informed consent. Histologically- or cytologically- confirmed diagnosis of metastatic NSCLC, metastasis can be regional lymph nodes or distant organs. Radiographic progression after treatment with the most recent line of treatment being either 3a or 3b: At least 12 weeks of PD-1/PD-L1 inhibitor in combination with platinum-based chemotherapy; Prior treatment with at least 2 cycles of a platinum-based chemotherapy, followed by at least 12 weeks of standard doses of PD-1 or PD-L1 inhibitor-based immunotherapy. Antibodies against CTLA-4, LAG-3, TIGIT, VEGF or VEGFR in combination with PD-1/PD-L1 inhibitor are allowed. At least one measurable tumor lesion according to RECIST 1.1. ECOG score of 0 or 1. Adequate organ functions. Serum LDH level ≤ 2xULN. Life expectancy ≥ 3 months. Exclusion Criteria (Major criteria): Cancer treatment related AEs have not recovered to NCI CTCAE grade≤ 1 except endocrinopathy. Last anti-PD-1/PD-L1 dosing within 28 days prior to first dose of study treatment. Receiving systemic steroid therapy with >10 mg/day prednisone or equivalent within 7 days prior to the first dose of study treatment. Having documented actionable mutations or genomic alterations in any of the following genes: EGFR, ALK, ROS1, HER2, MET, BRAF, RET or NTRK;. Exception: KRAS mutations are not excluded. Patients who have symptomatic brain metastasis. Palliative radiotherapy or radiosurgery to brain metastasis within 14 days of the first dose of study drug. Active GI disease, including peptic ulcer disease, pancreatitis, diverticulitis, or inflammatory bowel disease. Active interstitial lung disease (ILD) or non-infectious pneumonitis. Active infections with IV antibiotics within 14 days prior to first dose of study treatment. Impaired heart function.

Sites / Locations

  • XCancer/Dothan Hematology & Oncology - 1114Recruiting
  • Genesis Cancer and Blood Institute - 1123
  • The Oncology Institute (TOI) Clinical Research - 1109Recruiting
  • Sharp Healthcare - 1150
  • University of California at Davis - 1103Recruiting
  • Emad Ibrahim MD Inc. - 1147
  • University of Connecticut - 1111
  • Nuvance Health - 1118Recruiting
  • Ocala Oncology Center PL - 1102Recruiting
  • AdventHealth Cancer Institute - 1105Recruiting
  • Orlando Health - 1130
  • Florida Cancer Specialists -South - 1126
  • Florida Cancer Specialists -North - 1125
  • Florida Cancer Specialists -East - 1124
  • Orchard Healthcare Research, Inc. - 1116Recruiting
  • Springfield Clinic - The Cancer Center - 1110Recruiting
  • Fort Wayne Medical Oncology - 1133
  • Deaconess Chancellor Center for Oncology - 1131
  • Alliance for Multispecialty Research, LLC - 1144
  • University of Kentucky - Markey Cancer Center - 1112
  • Norton Cancer Institute - 1108Recruiting
  • Hematology Oncology Clinics - Baton Rouge - 1142
  • HealthPartners Institute, Cancer Research Center - 1143
  • Jefferson City Medical Group - 1145
  • Astera Cancer Care - 1128Recruiting
  • Messino Cancer Centers - 1121
  • University of Cincinnati Cancer Center - 1107
  • The Ohio State University James Cancer Center - 1104Recruiting
  • Miami Valley Hospital - 1115Recruiting
  • Oncology Associates of Oregon - 1138
  • Pennsylvania Cancer Specialists Research Institute - 1101Recruiting
  • Donald Guthrie Foundation - 1135
  • Cancer Care Associates of York, Inc. - 1113Recruiting
  • University of Tennessee Medical Center - 1146
  • Sarah Cannon Research Institute - Tennessee Oncology at Nashville - 1119Recruiting
  • Texas Oncology -Dallas - 1127
  • Texas Oncology - Denison - 1139
  • Texas Oncology - Fort Worth Cancer Center - 1141
  • Oncology Consultants, P.A. - 1120Recruiting
  • Texas Oncology - McAllen - 1132
  • Texas Oncology - Plano West - 1137
  • Texas Oncology -San Antonio - 1122
  • Texas Oncology - Northeast Texas - Tyler - 1134
  • NEXT Oncology - Virginia - 1129
  • Virginia Cancer Institute - 1149
  • Virginia Oncology Associates - 1136
  • MultiCare Institute for Research and Innovation - Tacoma - 1148
  • Bankstown Hospital - 3305
  • Newcastle Private Hospital - 3302
  • Mater - 3301
  • Cancer Research SA - 3303
  • AZ Maria Middelares - 2104
  • Jessa Ziekenhuis (Jessa Hospital) - Campus Salvator - 2102
  • C. H. R. de la Citadelle - 2103
  • Vitaz - Sint-niklaas Moerland - 2101
  • BC Cancer Centre - Kelowna - 1203
  • Saskatchewan Cancer Agency - Regina - 1201
  • Saskatchewan Cancer Agency - Saskatoon Cancer Centre - 1202
  • The First Affiliated Hospital of Anhui Medical University - 3221
  • Anhui Medical University - The Second Hospital - 3222
  • Beijing Cancer Hospital - 3205
  • Cancer Hospital, Chinese Academy of Medical Sciences - 3211
  • Fujian Medical University Union Hospital - 3225
  • The First Affiliated Hospital of Xiamen University - 3210
  • Dongguan People's Hospital - 3206
  • Guangdong Provincial People's Hospital - 3201Recruiting
  • Zhujiang Hospital of Southern Medical University - 3203
  • The First Affiliated Hospital of Guangdong Pharmaceutical University - 3215
  • The People's Hospital of Guangxi Zhuang Autonomous Region - 3228
  • Hainan General Hospital - 3202
  • Affiliated Hospital of Hebei University - 3214
  • The Affiliated Tumor Hospital of Harbin Medical University - 3232
  • Henan Cancer Hospital - 3226
  • The First Affliated Hospital of Zhengzhou University - 3207
  • Renmin Hospital of Wuhan University - 3216
  • Union Hospital Tongji Medical College - 3212
  • Xiangya Hospital, Central South University - 3223
  • Hunan Cancer Hospital - 3209
  • The Second Affiliated Hospital of Soochow University - 3217
  • Xuzhou Medical University - The Affiliated Hospital - 3234
  • The Second Affiliated Hospital of Nanchang University - 3224
  • Jinan Central Hospital - 3230
  • Shanxi Bethune Hospital - 3233
  • The First Affiliated Hospital of Xi'an Jiaotong University - 3218
  • Chengdu Seventh People's Hospital - 3229
  • Sichuan Cancer Hospital - 3227
  • Chongqing University Cancer Hospital - 3213
  • Tianjin Medical University Cancer Institute and Hospital - 3208
  • Yunnan Cancer Hospital - 3231
  • Sir Run Run Shaw Hospital, Zhejiang University School of Medicine - 3219
  • The Second Affiliated Hospital of Zhejiang University School of Medicine - 3220
  • Zhejiang Cancer Hospital - 3204
  • Hôpital Ambroise Paré - 2501
  • Centre Hospitalier Intercommunal de Créteil - 2502
  • CHU Limoges - Hospital du Cluzeau - 2503
  • Städt. Klinikum München GmbH - 2204
  • Kliniken Essen-Mitte - 2206
  • Klinikum Esslingen GmbH - 2201
  • Lungenfachklinik Immenhausen - 2202
  • Klinikverbund Allgaü - Klinikum Kempten - 2205
  • Asklepios Fachkliniken Muenchen-Gauting - 2203
  • Clinica Oncologica Ospedali Riuniti Ancona - 2311
  • IRCCS Istituto Tumori Giovanni Paolo II - 2306
  • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - 2310
  • Azienda Ospedaliera Papardo - 2301
  • Ospedale San Raffaele - 2307
  • Fondazione IRCCS Instituto Tumori Di Milano - 2305
  • Ospedale San Gerardo di Monza - 2302
  • Azienda Ospedaliera Universitaria "Federico II" - 2304
  • AOU Policlinico Giaccone, Università di Palermo - 2309
  • Universita degli Studi di Perugia - Ospedale Santa Maria della Misericordia - 2308
  • Universita Campus Bio-medico Di Roma (UCBM) - Policlinico Universitario - 2303
  • Chungbuk National University Hospital - 3101
  • Keimyung University Dongsan Hospital - 3102
  • National Cancer Center - 3107
  • Severance Hospital, Yonsei University Health System - 3104
  • Asan Medical Centre - 3103
  • Korea University Guro Hospital - 3106
  • The Catholic University of Korea, St Vincent's Hospital - 3105
  • Rijnstate Ziekenhuis - 2701
  • Jeroen Bosch Ziekenhuis - 2702
  • Hospital General Universitario de Elche - 2401
  • Hospital Universitario Lucus Augusti - 2405
  • Hospital General Universitario Gregorio Marañon - 2404
  • Hospital Regional Universitario de Malaga - 2403
  • Hospital General Universitario de Valencia - 2406
  • Fundacion Instituto Valenciano De Oncologia (IVO) - 2402
  • Adana Sehir Hastanesi - 2602
  • Baskent University Adana - 2601
  • Hacettepe Universitesi - 2609
  • Ankara Bilkent Sehir Hastanesi - 2610
  • Akdeniz University Medical Hospital - 2606
  • Trakya University Faculty of Medicine Edirne - 2608
  • Göztepe Prof Dr. Suleyman Yalcin City Hospital - 2605
  • Istanbul Bakirkoy Sadi Konuk - 2604
  • Medipol University Medical Faculty Hospital - 2603
  • Izmir Ekonomi Universitesi Medical Point Hastanesi - 2607
  • University Hospital Birmingham (UHB) / Queen Elizabeth Hospital Birmingham - 2801
  • Cambridge University Hospitals - 2804
  • University Hospital Leicester - 2806
  • The Christie NHS Foundation Trust - 2803
  • Barts Health NHS Trust (St. Bartholomew's Hospital) - 2802
  • Torbay Hospital - Horizon Centre - 2805

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Active Comparator

Arm Label

Arm 1: Gotistobart 6 mg/kg with 2 loading doses of 10 mg/kg, Q3W

Arm 2: Gotistobart 3 mg/kg Q3W

Arm 3: Docetaxel 75 mg/m2, Q3W

Arm Description

Gotistobart will be administrated by IV infusion in 60 minutes on day 1 of each cycle. A cycle is 21 days.

Gotistobart will be administrated by IV infusion in 60 minutes on day 1 of each cycle. A cycle is 21 days.

Docetaxel will be administrated by IV infusion in 60 minutes on day 1 of each cycle. A cycle is 21 days.

Outcomes

Primary Outcome Measures

Overall Survival (OS)
OS is defined as the time from randomization to the date of death by any cause. Kaplan-Meier estimates of median OS time will be presented by treatment arm with two sided 95% CIs.

Secondary Outcome Measures

Objective response rate (ORR)
Objective response rate (ORR) as assessed by Blinded Independent Central Review (BICR) per RECIST 1.1
Progression-free survival (PFS)
Progression-free survival (PFS) as assessed by Investigator per RECIST 1.1
Treatment emergent adverse events, treatment related adverse events and immune related adverse events.
Incidence of TEAEs, TRAEs, irAEs will be calcuated. The AEs leading to treatment discontinuation will be recorded.

Full Information

First Posted
December 26, 2022
Last Updated
October 10, 2023
Sponsor
OncoC4, Inc.
Collaborators
BioNTech SE
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1. Study Identification

Unique Protocol Identification Number
NCT05671510
Brief Title
ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors
Acronym
PRESERVE-003
Official Title
Phase 3, Two-stage, Randomized Study of ONC-392 Versus Docetaxel in Metastatic Non-Small Cell Lung Cancers That Progressed on PD-1/PD-L1 Inhibitors
Study Type
Interventional

2. Study Status

Record Verification Date
October 2023
Overall Recruitment Status
Recruiting
Study Start Date
June 28, 2023 (Actual)
Primary Completion Date
June 30, 2026 (Anticipated)
Study Completion Date
June 30, 2027 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
OncoC4, Inc.
Collaborators
BioNTech SE

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The goal of this Phase 3 clinical trial is study the safety and efficacy of the nextgen anti-CTLA-4 antibody, gotistobart (ONC-392/BNT316), in patients with metastatic non-small cell lung cancer who have disease progressed on anti-PD-1/PD-L1 antibody based therapy. The study will test whether gotistobart, in comparison with chemotherapy agent docetaxel, could prolong the life for NSCLC patients. Patients will be randomized to be treated with either gotistobart or docetaxel, IV infusion, once every 21 days, for up to 17 cycles in approximately one year.
Detailed Description
This is a seamless 2-stage, randomized, open-label, active-controlled, Phase 3 study. The study population consists of patients with NSCLC who progressed on PD-1/PD-L1 inhibitor. Approximately 600 patients will be enrolled. Two gotistobart dosing regimens will be tested in Stage I, and one will be selected for Stage II. Stage I, the dose-confirmation stage, will assess the efficacy and safety of two gotistobart dosing regimens (3 mg/kg Q3W and 6 mg/kg Q3W with 2 loading doses of 10 mg/kg Q3W) in comparison to docetaxel 75 mg/m2 Q3W. Stage II will assess the safety and efficacy of gotistobart at the selected dosing regimen versus docetaxel. Patients will be randomized 1:1 to receive either gotistobart at the selected dosing regimen or docetaxel.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Non Small Cell Lung Cancer

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Model Description
Randomized, open-label, active controlled, multi-center Phase 3 study.
Masking
None (Open Label)
Allocation
Randomized
Enrollment
600 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Arm 1: Gotistobart 6 mg/kg with 2 loading doses of 10 mg/kg, Q3W
Arm Type
Experimental
Arm Description
Gotistobart will be administrated by IV infusion in 60 minutes on day 1 of each cycle. A cycle is 21 days.
Arm Title
Arm 2: Gotistobart 3 mg/kg Q3W
Arm Type
Experimental
Arm Description
Gotistobart will be administrated by IV infusion in 60 minutes on day 1 of each cycle. A cycle is 21 days.
Arm Title
Arm 3: Docetaxel 75 mg/m2, Q3W
Arm Type
Active Comparator
Arm Description
Docetaxel will be administrated by IV infusion in 60 minutes on day 1 of each cycle. A cycle is 21 days.
Intervention Type
Drug
Intervention Name(s)
Gotistobart
Other Intervention Name(s)
A humanized anti-CTLA4 IgG1 monoclonal antibody, ONC-392, BNT316
Intervention Description
Gotistobart will be administrated through IV infusion over 60 minutes, once every 21 days in assigned dose.
Intervention Type
Drug
Intervention Name(s)
Docetaxel
Other Intervention Name(s)
Docefrez, Taxotere
Intervention Description
Docetaxel will be administrated through IV infusion over 60 minutes, once every 21 days in 75mg/m2 dose.
Primary Outcome Measure Information:
Title
Overall Survival (OS)
Description
OS is defined as the time from randomization to the date of death by any cause. Kaplan-Meier estimates of median OS time will be presented by treatment arm with two sided 95% CIs.
Time Frame
36 months
Secondary Outcome Measure Information:
Title
Objective response rate (ORR)
Description
Objective response rate (ORR) as assessed by Blinded Independent Central Review (BICR) per RECIST 1.1
Time Frame
36 months
Title
Progression-free survival (PFS)
Description
Progression-free survival (PFS) as assessed by Investigator per RECIST 1.1
Time Frame
36 months
Title
Treatment emergent adverse events, treatment related adverse events and immune related adverse events.
Description
Incidence of TEAEs, TRAEs, irAEs will be calcuated. The AEs leading to treatment discontinuation will be recorded.
Time Frame
36 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria (Major criteria): Adult (≥ 18 years), all genders, capable of signing informed consent. Histologically- or cytologically- confirmed diagnosis of metastatic NSCLC, metastasis can be regional lymph nodes or distant organs. Radiographic progression after treatment with the most recent line of treatment being either 3a or 3b: At least 12 weeks of PD-1/PD-L1 inhibitor in combination with platinum-based chemotherapy; Prior treatment with at least 2 cycles of a platinum-based chemotherapy, followed by at least 12 weeks of standard doses of PD-1 or PD-L1 inhibitor-based immunotherapy. Antibodies against CTLA-4, LAG-3, TIGIT, VEGF or VEGFR in combination with PD-1/PD-L1 inhibitor are allowed. At least one measurable tumor lesion according to RECIST 1.1. ECOG score of 0 or 1. Adequate organ functions. Serum LDH level ≤ 2xULN. Life expectancy ≥ 3 months. Exclusion Criteria (Major criteria): Cancer treatment related AEs have not recovered to NCI CTCAE grade≤ 1 except endocrinopathy. Last anti-PD-1/PD-L1 dosing within 28 days prior to first dose of study treatment. Receiving systemic steroid therapy with >10 mg/day prednisone or equivalent within 7 days prior to the first dose of study treatment. Having documented actionable mutations or genomic alterations in any of the following genes: EGFR, ALK, ROS1, HER2, MET, BRAF, RET or NTRK;. Exception: KRAS mutations are not excluded. Patients who have symptomatic brain metastasis. Palliative radiotherapy or radiosurgery to brain metastasis within 14 days of the first dose of study drug. Active GI disease, including peptic ulcer disease, pancreatitis, diverticulitis, or inflammatory bowel disease. Active interstitial lung disease (ILD) or non-infectious pneumonitis. Active infections with IV antibiotics within 14 days prior to first dose of study treatment. Impaired heart function.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Pan Zheng, MD, PhD
Phone
2027516823
Email
pzheng@oncoc4.com
First Name & Middle Initial & Last Name or Official Title & Degree
Martin Devenport, PhD
Phone
4102070582
Email
mdevenport@oncoc4.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Mark Socinski, MD
Organizational Affiliation
Advent Health System
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Tianhong Li, MD, PhD
Organizational Affiliation
University of California, Davis
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Kai He, MD, PhD
Organizational Affiliation
Ohio State University
Official's Role
Principal Investigator
Facility Information:
Facility Name
XCancer/Dothan Hematology & Oncology - 1114
City
Dothan
State/Province
Alabama
ZIP/Postal Code
36303
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jawaunna Blackmon, MD
Facility Name
Genesis Cancer and Blood Institute - 1123
City
Russellville
State/Province
Arkansas
ZIP/Postal Code
72801
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Timothy Webb, MD
Facility Name
The Oncology Institute (TOI) Clinical Research - 1109
City
Cerritos
State/Province
California
ZIP/Postal Code
90703
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Omkar Marathe, MD
Facility Name
Sharp Healthcare - 1150
City
Chula Vista
State/Province
California
ZIP/Postal Code
91911
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kenneth Johnson, MD
Facility Name
University of California at Davis - 1103
City
Davis
State/Province
California
ZIP/Postal Code
95817
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tianhong Li, MD, PhD
Facility Name
Emad Ibrahim MD Inc. - 1147
City
Redlands
State/Province
California
ZIP/Postal Code
92373
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Emad Ibrahim, MD
Facility Name
University of Connecticut - 1111
City
Farmington
State/Province
Connecticut
ZIP/Postal Code
06030
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Susan Tannenbaum, MD
Facility Name
Nuvance Health - 1118
City
Norwalk
State/Province
Connecticut
ZIP/Postal Code
06850
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Richard Frank, MD
Facility Name
Ocala Oncology Center PL - 1102
City
Ocala
State/Province
Florida
ZIP/Postal Code
34474
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rama Balaraman, MD
Facility Name
AdventHealth Cancer Institute - 1105
City
Orlando
State/Province
Florida
ZIP/Postal Code
32804
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mark Socinski, MD
Facility Name
Orlando Health - 1130
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tirrell Johnson, MD
Facility Name
Florida Cancer Specialists -South - 1126
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34232
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fadi Kayali, MD
Facility Name
Florida Cancer Specialists -North - 1125
City
The Villages
State/Province
Florida
ZIP/Postal Code
32159
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Adewale Fawole, MD
Facility Name
Florida Cancer Specialists -East - 1124
City
West Palm Beach
State/Province
Florida
ZIP/Postal Code
33401
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Todd Gersten, MD
Facility Name
Orchard Healthcare Research, Inc. - 1116
City
Skokie
State/Province
Illinois
ZIP/Postal Code
60077
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ira Oliff, MD
Facility Name
Springfield Clinic - The Cancer Center - 1110
City
Springfield
State/Province
Illinois
ZIP/Postal Code
62702
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Preet Singh, MD
Facility Name
Fort Wayne Medical Oncology - 1133
City
Fort Wayne
State/Province
Indiana
ZIP/Postal Code
46805
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ahad Sadiq, MD
Facility Name
Deaconess Chancellor Center for Oncology - 1131
City
Newburgh
State/Province
Indiana
ZIP/Postal Code
47630
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yasoda Devabhaktuni, MD
Facility Name
Alliance for Multispecialty Research, LLC - 1144
City
Merriam
State/Province
Kansas
ZIP/Postal Code
66204
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jaswinder Singh, MD
Facility Name
University of Kentucky - Markey Cancer Center - 1112
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40536
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhonglin Hao, MD, PhD
Facility Name
Norton Cancer Institute - 1108
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
John Hamm, MD
Facility Name
Hematology Oncology Clinics - Baton Rouge - 1142
City
Baton Rouge
State/Province
Louisiana
ZIP/Postal Code
70809
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christopher McCanless, MD
Facility Name
HealthPartners Institute, Cancer Research Center - 1143
City
Saint Louis Park
State/Province
Minnesota
ZIP/Postal Code
55426
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dylan Zylla, MD, MS
Facility Name
Jefferson City Medical Group - 1145
City
Jefferson City
State/Province
Missouri
ZIP/Postal Code
65109
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shadi Haddadin, MD
Facility Name
Astera Cancer Care - 1128
City
East Brunswick
State/Province
New Jersey
ZIP/Postal Code
08816
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bruno Fang, MD
Facility Name
Messino Cancer Centers - 1121
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28806
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andrew Beardsley, MD
Facility Name
University of Cincinnati Cancer Center - 1107
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jennifer Leddon, MD, PhD
Facility Name
The Ohio State University James Cancer Center - 1104
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kai He, MD, PhD
Facility Name
Miami Valley Hospital - 1115
City
Dayton
State/Province
Ohio
ZIP/Postal Code
45409
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tarek Sabagh, MD
Facility Name
Oncology Associates of Oregon - 1138
City
Eugene
State/Province
Oregon
ZIP/Postal Code
97401
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bo Wang, MD
Facility Name
Pennsylvania Cancer Specialists Research Institute - 1101
City
Gettysburg
State/Province
Pennsylvania
ZIP/Postal Code
17325
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Satish Shah, MD
Facility Name
Donald Guthrie Foundation - 1135
City
Sayre
State/Province
Pennsylvania
ZIP/Postal Code
18840
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joyson Poulose, MD
Facility Name
Cancer Care Associates of York, Inc. - 1113
City
York
State/Province
Pennsylvania
ZIP/Postal Code
17403
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chanh Huynh, MD
Facility Name
University of Tennessee Medical Center - 1146
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37920
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ardalan Davarifar, MD, PhD
Facility Name
Sarah Cannon Research Institute - Tennessee Oncology at Nashville - 1119
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Melissa Johnson, MD
Facility Name
Texas Oncology -Dallas - 1127
City
Dallas
State/Province
Texas
ZIP/Postal Code
75230
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jay Courtright, MD
Facility Name
Texas Oncology - Denison - 1139
City
Denison
State/Province
Texas
ZIP/Postal Code
75020
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Amir Faridi, MD
Facility Name
Texas Oncology - Fort Worth Cancer Center - 1141
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76105
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rahel Theriault, MD
Facility Name
Oncology Consultants, P.A. - 1120
City
Houston
State/Province
Texas
ZIP/Postal Code
77024
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Julio Peguero, MD
Facility Name
Texas Oncology - McAllen - 1132
City
McAllen
State/Province
Texas
ZIP/Postal Code
78503
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Habib Ghaddar, MD, FACP
Facility Name
Texas Oncology - Plano West - 1137
City
Plano
State/Province
Texas
ZIP/Postal Code
75093
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Philip Kovoor, MD
Facility Name
Texas Oncology -San Antonio - 1122
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78240
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Krishna Alluri, MD
Facility Name
Texas Oncology - Northeast Texas - Tyler - 1134
City
Tyler
State/Province
Texas
ZIP/Postal Code
75702
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Donald Richards, MD
Facility Name
NEXT Oncology - Virginia - 1129
City
Fairfax
State/Province
Virginia
ZIP/Postal Code
22031
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yin Chao, MD
Facility Name
Virginia Cancer Institute - 1149
City
Henrico
State/Province
Virginia
ZIP/Postal Code
23226
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rachit Kumar, MD
Facility Name
Virginia Oncology Associates - 1136
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23502
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
John Paschold, MD
Facility Name
MultiCare Institute for Research and Innovation - Tacoma - 1148
City
Spokane
State/Province
Washington
ZIP/Postal Code
99218
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jay Wittenkeller, MD
Facility Name
Bankstown Hospital - 3305
City
Bankstown
State/Province
New South Wales
ZIP/Postal Code
2200
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
Newcastle Private Hospital - 3302
City
Newcastle
State/Province
New South Wales
ZIP/Postal Code
2305
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
Mater - 3301
City
Newstead
State/Province
Queensland
ZIP/Postal Code
4006
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
Cancer Research SA - 3303
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
AZ Maria Middelares - 2104
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paul Germonpre, MD, PhD
Facility Name
Jessa Ziekenhuis (Jessa Hospital) - Campus Salvator - 2102
City
Hasselt
ZIP/Postal Code
3500
Country
Belgium
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kristof Cuppens, MD, MSc
Facility Name
C. H. R. de la Citadelle - 2103
City
Liège
ZIP/Postal Code
4000
Country
Belgium
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Frederique Bustin, MD
Facility Name
Vitaz - Sint-niklaas Moerland - 2101
City
Sint-Niklaas
ZIP/Postal Code
9100
Country
Belgium
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Koenraad Deschepper, MD
Facility Name
BC Cancer Centre - Kelowna - 1203
City
Kelowna
State/Province
British Columbia
Country
Canada
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Guillermo Martos, MD
Facility Name
Saskatchewan Cancer Agency - Regina - 1201
City
Regina
State/Province
Saskatchewan
ZIP/Postal Code
S4T 7T1
Country
Canada
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mussawar Iqbal, MD
Facility Name
Saskatchewan Cancer Agency - Saskatoon Cancer Centre - 1202
City
Saskatoon
State/Province
Saskatchewan
ZIP/Postal Code
S7N 4H4
Country
Canada
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sunil Yadav, MD
Facility Name
The First Affiliated Hospital of Anhui Medical University - 3221
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230022
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kangsheng Gu, MD
Facility Name
Anhui Medical University - The Second Hospital - 3222
City
Hefei
State/Province
Anhui
ZIP/Postal Code
231200
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hui Zhao, MD
Facility Name
Beijing Cancer Hospital - 3205
City
Beijing
State/Province
Beijing
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jian Fang, MD
Facility Name
Cancer Hospital, Chinese Academy of Medical Sciences - 3211
City
Beijing
State/Province
Beijing
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Puyuan Xing, MD
Facility Name
Fujian Medical University Union Hospital - 3225
City
Fuzhou
State/Province
Fujian
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaoyan Lin, MD
Facility Name
The First Affiliated Hospital of Xiamen University - 3210
City
Xiamen
State/Province
Fujian
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jingxun Wu, MD
Facility Name
Dongguan People's Hospital - 3206
City
Dongguan
State/Province
Guangdong
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhigang Liu, MD
Facility Name
Guangdong Provincial People's Hospital - 3201
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510105
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Huajun Chen, MD
Facility Name
Zhujiang Hospital of Southern Medical University - 3203
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510280
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jian Zhang, MD
Facility Name
The First Affiliated Hospital of Guangdong Pharmaceutical University - 3215
City
Guangzhou
State/Province
Guangdong
Country
China
Individual Site Status
Not yet recruiting
Facility Name
The People's Hospital of Guangxi Zhuang Autonomous Region - 3228
City
Nanning
State/Province
Guangxi
ZIP/Postal Code
530021
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yanrong Hao, MD
Facility Name
Hainan General Hospital - 3202
City
Haikou
State/Province
Hainan
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xicheng Wang, MD
Facility Name
Affiliated Hospital of Hebei University - 3214
City
Zhengzhou
State/Province
Hebei
ZIP/Postal Code
71000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zizheng Song, MD
Facility Name
The Affiliated Tumor Hospital of Harbin Medical University - 3232
City
Harbin
State/Province
Heilongjiang
ZIP/Postal Code
150040
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yan Yu, MD
Facility Name
Henan Cancer Hospital - 3226
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450008
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Qiming Wang, MD
Facility Name
The First Affliated Hospital of Zhengzhou University - 3207
City
Zhengzhou
State/Province
Henan
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xingya Li, MD
Facility Name
Renmin Hospital of Wuhan University - 3216
City
Wuhan
State/Province
Hubei
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ximing Xu, MD
Facility Name
Union Hospital Tongji Medical College - 3212
City
Wuhan
State/Province
Hubei
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaorong Dong, MD
Facility Name
Xiangya Hospital, Central South University - 3223
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410008
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pinhua Pan, MD
Facility Name
Hunan Cancer Hospital - 3209
City
Changsha
State/Province
Hunan
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lin Wu, MD
Facility Name
The Second Affiliated Hospital of Soochow University - 3217
City
Suzhou
State/Province
Jiangsu
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhixiang Zhang, MD
Facility Name
Xuzhou Medical University - The Affiliated Hospital - 3234
City
Xuzhou
State/Province
Jiangsu
ZIP/Postal Code
221002
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bi Chen, MD
Facility Name
The Second Affiliated Hospital of Nanchang University - 3224
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anwen Liu, MD
Facility Name
Jinan Central Hospital - 3230
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250013
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Meili Sun, MD
Facility Name
Shanxi Bethune Hospital - 3233
City
Taiyuan
State/Province
Shanxi
ZIP/Postal Code
30032
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Huijing Feng, MD
Facility Name
The First Affiliated Hospital of Xi'an Jiaotong University - 3218
City
Xi'an
State/Province
Shanxi
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hong Sun, MD
Facility Name
Chengdu Seventh People's Hospital - 3229
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610041
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jiliang Zhang, MD
Facility Name
Sichuan Cancer Hospital - 3227
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610041
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Juan Li, MD
Facility Name
Chongqing University Cancer Hospital - 3213
City
Chongqing
State/Province
Sichuan
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Luchun Li, MD
Facility Name
Tianjin Medical University Cancer Institute and Hospital - 3208
City
Tianjin
State/Province
Tianjin
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xinwei Zhang, MD
Facility Name
Yunnan Cancer Hospital - 3231
City
Kunming
State/Province
Yunnan
ZIP/Postal Code
650118
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Runxiang Yang, MD
Facility Name
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine - 3219
City
Hangzhou
State/Province
Zhejiang
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hongming Pan, MD
Facility Name
The Second Affiliated Hospital of Zhejiang University School of Medicine - 3220
City
Hangzhou
State/Province
Zhejiang
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wen Li, MD
Facility Name
Zhejiang Cancer Hospital - 3204
City
Hangzhou
State/Province
Zhejiang
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xinmin Yu, MD
Facility Name
Hôpital Ambroise Paré - 2501
City
Billancourt
ZIP/Postal Code
92100
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Etienne Giroux Leprieur, MD
Facility Name
Centre Hospitalier Intercommunal de Créteil - 2502
City
Créteil
ZIP/Postal Code
94000
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christos Chouaid, MD
Facility Name
CHU Limoges - Hospital du Cluzeau - 2503
City
Limoges
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alain Vergnenegre, MD
Facility Name
Städt. Klinikum München GmbH - 2204
City
Bogenhausen
ZIP/Postal Code
81925
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Konrad Kokowski, MD
Facility Name
Kliniken Essen-Mitte - 2206
City
Essen
ZIP/Postal Code
45136
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Daniel Christoph, MD
Facility Name
Klinikum Esslingen GmbH - 2201
City
Esslingen am Neckar
ZIP/Postal Code
73730
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Faehling, MD, MSc
Facility Name
Lungenfachklinik Immenhausen - 2202
City
Immenhausen
ZIP/Postal Code
34376
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Achim Rittmeyer, MD
Facility Name
Klinikverbund Allgaü - Klinikum Kempten - 2205
City
Immenstädt
ZIP/Postal Code
87509
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christian Schumann, MD, PhD
Facility Name
Asklepios Fachkliniken Muenchen-Gauting - 2203
City
Muenchen-Gauting
ZIP/Postal Code
82131
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Niels Reinmuth, MD, PhD
Facility Name
Clinica Oncologica Ospedali Riuniti Ancona - 2311
City
Ancona
ZIP/Postal Code
60126
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rossana Berardi, MD
Facility Name
IRCCS Istituto Tumori Giovanni Paolo II - 2306
City
Bari
ZIP/Postal Code
70124
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Domenico Galetta, MD, PhD
Facility Name
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - 2310
City
Bergamo
ZIP/Postal Code
24126
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anna Cecilia Bettini, MD
Facility Name
Azienda Ospedaliera Papardo - 2301
City
Messina
ZIP/Postal Code
98158
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alessandro Russo, MD, PhD
Facility Name
Ospedale San Raffaele - 2307
City
Milano
ZIP/Postal Code
20132
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alessandra Bulotta, MD
Facility Name
Fondazione IRCCS Instituto Tumori Di Milano - 2305
City
Milano
ZIP/Postal Code
20133
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Giuseppe Lo Russo, MD, PhD
Facility Name
Ospedale San Gerardo di Monza - 2302
City
Monza
ZIP/Postal Code
20900
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Diego Cortinovis, MD
Facility Name
Azienda Ospedaliera Universitaria "Federico II" - 2304
City
Naples
ZIP/Postal Code
80131
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alberto Servetto, MD, PhD
Facility Name
AOU Policlinico Giaccone, Università di Palermo - 2309
City
Palermo
ZIP/Postal Code
90129
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Valerio Gristina, MD, PhD
Facility Name
Universita degli Studi di Perugia - Ospedale Santa Maria della Misericordia - 2308
City
Perugia
ZIP/Postal Code
06132
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rita Chiari, MD
Facility Name
Universita Campus Bio-medico Di Roma (UCBM) - Policlinico Universitario - 2303
City
Roma
ZIP/Postal Code
00128
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alessio Cortellini, MD, PhD
Facility Name
Chungbuk National University Hospital - 3101
City
Cheongju-si
ZIP/Postal Code
28644
Country
Korea, Republic of
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ki Hyeong Lee, MD, PhD
Facility Name
Keimyung University Dongsan Hospital - 3102
City
Daegu
ZIP/Postal Code
42601
Country
Korea, Republic of
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Keon Uk Park, MD
Facility Name
National Cancer Center - 3107
City
Goyang-si
ZIP/Postal Code
10408
Country
Korea, Republic of
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Young Joo Lee, MD, MMM
Facility Name
Severance Hospital, Yonsei University Health System - 3104
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Byoung Chul Cho, MD
Facility Name
Asan Medical Centre - 3103
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sang-We Kim, MD
Facility Name
Korea University Guro Hospital - 3106
City
Seoul
ZIP/Postal Code
08308
Country
Korea, Republic of
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eun Joo Kang, MD
Facility Name
The Catholic University of Korea, St Vincent's Hospital - 3105
City
Suwon
ZIP/Postal Code
16247
Country
Korea, Republic of
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Byoung Yong Shim, MD
Facility Name
Rijnstate Ziekenhuis - 2701
City
Arnhem
ZIP/Postal Code
6815
Country
Netherlands
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Niels Claessens, MD
Facility Name
Jeroen Bosch Ziekenhuis - 2702
City
Herzogenbusch
ZIP/Postal Code
5223
Country
Netherlands
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bianca Van Veggel, MD
Facility Name
Hospital General Universitario de Elche - 2401
City
Elche
ZIP/Postal Code
03203
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria Guirado Risueno, MD
Facility Name
Hospital Universitario Lucus Augusti - 2405
City
Lugo
ZIP/Postal Code
27003
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sergio Vazquez Estevez, MD
Facility Name
Hospital General Universitario Gregorio Marañon - 2404
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Antonio Calles Blanco, MD
Facility Name
Hospital Regional Universitario de Malaga - 2403
City
Málaga
ZIP/Postal Code
29010
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Manuel Cobo Dols, MD, PhD
Facility Name
Hospital General Universitario de Valencia - 2406
City
Valencia
ZIP/Postal Code
46014
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ana Blasco Cordellat, MD
Facility Name
Fundacion Instituto Valenciano De Oncologia (IVO) - 2402
City
Valencia
ZIP/Postal Code
56009
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ignacio Gil-Bazo, MD, PhD
Facility Name
Adana Sehir Hastanesi - 2602
City
Adana
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Timucin Cil, MD
Facility Name
Baskent University Adana - 2601
City
Adana
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fatih Kose, MD
Facility Name
Hacettepe Universitesi - 2609
City
Ankara
ZIP/Postal Code
06230
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mustafa Erman, MD
Facility Name
Ankara Bilkent Sehir Hastanesi - 2610
City
Ankara
ZIP/Postal Code
06800
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mehmet Ali nahit Sendur, MD
Facility Name
Akdeniz University Medical Hospital - 2606
City
Antalya
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sema Sezgin Goksu, MD
Facility Name
Trakya University Faculty of Medicine Edirne - 2608
City
Edirne
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bulent Erdogan, MD
Facility Name
Göztepe Prof Dr. Suleyman Yalcin City Hospital - 2605
City
Istanbul
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mahmut Gumus, MD
Facility Name
Istanbul Bakirkoy Sadi Konuk - 2604
City
Istanbul
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Deniz Tural, MD
Facility Name
Medipol University Medical Faculty Hospital - 2603
City
Istanbul
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ahmet Bilici, MD
Facility Name
Izmir Ekonomi Universitesi Medical Point Hastanesi - 2607
City
İzmir
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Cagatay Arslan, MD
Facility Name
University Hospital Birmingham (UHB) / Queen Elizabeth Hospital Birmingham - 2801
City
Birmingham
State/Province
England
ZIP/Postal Code
B15 2TG
Country
United Kingdom
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gary Middleton, MD
Facility Name
Cambridge University Hospitals - 2804
City
Cambridge
State/Province
England
ZIP/Postal Code
CB2 0QQ
Country
United Kingdom
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Philip Earwaker, MD
Facility Name
University Hospital Leicester - 2806
City
Leicester
State/Province
England
ZIP/Postal Code
LE1 5WW
Country
United Kingdom
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sean Dulloo, MRCP, MSc
Facility Name
The Christie NHS Foundation Trust - 2803
City
London
State/Province
England
ZIP/Postal Code
EC1A 7BE
Country
United Kingdom
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fabio Gomes, MD, MRes
Facility Name
Barts Health NHS Trust (St. Bartholomew's Hospital) - 2802
City
Manchester
State/Province
England
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Farah Louise Lim, MRCP
Facility Name
Torbay Hospital - Horizon Centre - 2805
City
Torquay
State/Province
England
ZIP/Postal Code
TQ2 7AA
Country
United Kingdom
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Louise / Jonathan Medley / Buckley, MD

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
31267017
Citation
Zhang Y, Du X, Liu M, Tang F, Zhang P, Ai C, Fields JK, Sundberg EJ, Latinovic OS, Devenport M, Zheng P, Liu Y. Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy. Cell Res. 2019 Aug;29(8):609-627. doi: 10.1038/s41422-019-0184-1. Epub 2019 Jul 2.
Results Reference
background
PubMed Identifier
31836191
Citation
Liu Y, Zheng P. Preserving the CTLA-4 Checkpoint for Safer and More Effective Cancer Immunotherapy. Trends Pharmacol Sci. 2020 Jan;41(1):4-12. doi: 10.1016/j.tips.2019.11.003. Epub 2019 Dec 10.
Results Reference
background

Learn more about this trial

ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors

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