Effects of a Colon-delivered Multivitamin Supplement on Brain Functioning, Immunometabolic- and Intestinal Markers in Ageing (COMBI)

Inclusion Criteria: Written informed consent Age between 60-75 years (at pre-screening) Fluency in Dutch (speaking, reading and writing) Score ≥2 points on the risk factor scale below based on self report: BMI≥25 (1 point) Physical inactivity (according to WHO guidelines) (1 point) Hypertension (1 point) Hypertension without medication (1 point) Hypercholesterolemia (1 point) Diabetes type II (1 point) Mild cardiovascular disease (1 point) Exclusion Criteria: Food allergies or other issues with the vitamins included in the supplement Concurrent participation in other intervention trials Clinical diagnosis of ≥1 of the following: Stroke; Neurological disease(s) (e.g. MCI, dementia, MS, Parkinson's, epilepsy); Current malignant disease(s), with or without treatment; Current psychiatric disorder(s) (e.g. depression, psychosis, bipolar episodes, eating disorder); Symptomatic cardiovascular disease (e.g. stroke, angina pectoris, heart failure, myocardial infarction); Revascularisation surgery in the last 12 months at pre-screening; Gastrointestinal diseases (i.e., diarrhoea, Crohn's disease, ulcerative colitis, diverticulosis, stomach or duodenal ulcers) or having a history of gastrointestinal surgical events (e.g. stoma) that may influence the results of the study, as determined by the study team; Visual impairment (e.g. blindness); Hearing or communicative impairment. Use of antibiotics within the previous 3 months before the study start. Use of protonpump inhibitors within the study period (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole) Not willing to refrain from taking other supplements (containing vitamin B2, B3, B6, B9, or C, prebiotic, or probiotic) that can interfere with the study outcomes, from at least 2 weeks before start of the intervention till the end of the intervention period. Answering "Yes" on ≥1 of the Donders Institute MRI safety screening protocol questions (see the 8 questions below): Are there metal objects located in your upper body? Exception: tooth-fillings and/or dental crowns. Are there metal splinters in your body, in particular within the eyes? For example: through labour work in the metal industry. Are there jewellery items or piercings that you are unable to take off? Have you had a brain surgery in the past? Are there active implants present? For example: pacemaker, neurostimulator, insulin pump, hearing aid (that is unable to be removed). Are there any medical plasters or patches that you can't or may not take off? For example: nicotine patch. Do you suffer from epilepsy? Do you suffer from claustrophobia? Cognitive impairment as determined by Telephone Interview for Cognitive Status (TICS-M1), performed during pre-screening before inclusion and defined as a score <23.