Antioxidant and Immune Effects of Vitamin K2 (ProteK2t)

Inclusion Criteria: Self-reported postmenopausal (at least one year after the final menstruation) BMI ≥25 and ≤32 kg/m2; Plasma dp-ucMGP concentration in highest 50-66% of the screened population Non-smoking, defined as not smoking currently and not having smoked (at all) in the year before study start; Healthy as assessed by the health questionnaire and according to the judgment of the study physician; Voluntary participation; Having given written informed consent; Willing to comply with study procedures; Exclusion Criteria: Plasma dp-ucMGP concentration >1000 pmol/L at screening Treatment with oral antibiotics within 2 months of the start of the study Any vaccination in the month before study start or any scheduled vaccination during the study period Use of antioxidant or vitamin K and D supplements; Use of antioxidant or vitamin K and D supplements in the month before the start of the study; Use of aspirin or medication with established antioxidant or anti-inflammatory properties; Use of medication that interferes with vitamin K or blood coagulation; Use of statins to reduce level of low-density lipoprotein cholesterol in the blood; Hyperlipidaemia, diabetes, hypertension, intestinal disease, diseases with an inflammation component; Hormone replacement therapy in women; Follow a vegetarian or vegan diet; Participation in any clinical trial including blood sampling and/or administration of substances up to 30 days before day 1 of this study; Alcohol consumption for men > 28 units/week and >4/day; for women: >21 units/week and >3/day; Reported unexpected weight loss or weight gain of > 3 kg in the month prior to pre-study screening, or intention to lose weight during the study period; Reported slimming or medically prescribed diet; Recent blood donation (<1 month prior to Day 01 of the study); Not willing to give up blood donation during the study;