Clinical Study on the Efficacy of Autologous Cell Factor Induced Killer Cells in the Treatment of Colorectal Cancer
Colorectal Cancer
About this trial
This is an interventional treatment trial for Colorectal Cancer focused on measuring Autologous cytokine induced killer cells
Eligibility Criteria
Inclusion Criteria: Age range 18-70 years; Patients diagnosed with colorectal cancer, TNM stage III-IV; Had at least one extracranially measurable lesion by recist1.1 criteria; ④ Patients who had failed at least one or two prior lines of standard therapy or relapsed, or who were intolerant to or voluntarily abandoned one or two prior lines of standard therapy; ⑤ Expected survival ≥ 90 days; The major organs function normally; ⑦ The subject voluntarily joined this study, signed the informed consent, complied well and cooperated with the follow-up. Exclusion Criteria: Had participated in other clinical trialists of drugs within 4 weeks before the start of the study; Those who had hypertension that was inadequately controlled with a single antihypertensive agent (systolic blood pressure > 140 mmHg and diastolic blood pressure > 90 mmHg, as judged by the investigator), had myocardial ischemia or myocardial infarction of grade I or higher, arrhythmia of grade I and higher (including QT interval ≥ 440 MS), or cardiac dysfunction; Those with a history of substance abuse who are unable to abstain or who have a history of mental disorders; Presence of fungal, bacterial, viral, or other infections that are not controllable or require antibiotic therapy; For subjects with prior chemotherapy use, ≥ grade 2 hematologic toxicity, or ≥ grade 3 nonhematologic toxicity according to nci-ctcae 5.0 criteria at enrollment; ⑥ Known presence of a history of HIV, or hepatitis B (HBsAg positive) or hepatitis C virus (anti HCV positive) nucleic acid test positive; Presence of any indwelling catheter or drain (eg, biliary drain or pleural / peritoneal / pericardial catheter). Use of a dedicated central venous catheter was permitted (colostomy for patients with bowel cancer, percutaneous nephrostomy tube, indwelling Frey catheter, considered by the investigator for implications); ⑧ Presence of brain metastases, presence of a history or disease of the CNS such as seizure disorders, cerebral ischemia / hemorrhage, dementia, cerebellar disease, or any autoimmune disease involving the CNS;
Sites / Locations
- Southwest Hospital, Army Medical University (Third Military Medical University)Recruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
CIK combined with chemotherapy group
CIK combined immunotherapy group
CIK combined targeted therapy group
CIK in combination with other therapies
Combination of CIK cells and chemotherapy
Combination of CIK cells and immunotherapy
Combination of CIK cells and targeted therapy
CIK in combination with any two or three of these (i.e., chemotherapy, immunotherapy, and targeted therapy) treatments