Cardiotoxicity Monitoring With Single-lead Electrocardiogram
Cardiotoxicity
About this trial
This is an interventional diagnostic trial for Cardiotoxicity focused on measuring 1-minute, single-lead ECG, cardiotoxicity, chemotherapy
Eligibility Criteria
Inclusion Criteria: chemotherapy-naive patients with first time diagnosed various kinds of tumors, planned for the first cycle polychemotherapy treatment over 18 years old Written informed consent to participate in the study. Patients without decompensation of cardiovascular diseases Non-inclusion criteria: Pregnancy; Severe hepatic and\or renal failure(glomerular filtration rate below 30 (ml\min\1.732) Cockcroft-Gault, Child-Pugh score less than 6 points; Radiation therapy and\or any surgical treatment in last 30 days. Heart failure with left ventricular ejection fraction< 50 %, III-IV functional class New York Heart Association Functional Classification (NYHA) Cardiac arrhythmias - permanent form of atrial fibrillation\flutter, atrioventricular block (AV block) II-III degree Congenital or acquired heart valve disease Patients with impaired motor function or tremor of the upper limb. As well as patients with severe cognitive impairments Patients with a minimum life expectancy of less than 1 month Exclusion Criteria: Refusal to further participate in the study; Non-compliance to the therapy regimen. Poor quality ECG, poor echocardiography visualization,detection a defect of the preanalytical stage of the blood biochemical analysis (hemolysis, non-compliance with the temperature regime, long-term transportation, long-term storage, long-term or repeated centrifugation). Development of other toxicity during chemotherapy treatment, which might prevents the evaluation of the study results
Sites / Locations
- I.M. Sechenov First Moscow State Medical University (Sechenov University)Recruiting
Arms of the Study
Arm 1
Experimental
monitoring group
a group of chemotherapy-naive patients with first time diagnosed various kinds of tumors, planned for the first cycle polychemotherapy treatment.