Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-III)
Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection
About this trial
This is an interventional prevention trial for Prosthesis and Implants
Eligibility Criteria
Inclusion Criteria: Healthy male and female participants ≥ 18 years who volunteer for the pilot study, in which a routine photodynamic treatment at the Department of Dermatology will be performed and effect of skin colonization will be analyzed, and who signed an informed consent (after information about the project) Exclusion Criteria: Pregnant and breastfeeding women Participants with inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc., Participants taking antibiotics in the 14 days prior to PDT or until follow-up at 21 days Participants who received oral retinoid therapy within the last 6 months Participants who received anti-inflammatory agents as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) within the 14 days prior and after the PDT Participants taking any photosensitizing drugs within 4 weeks prior to PDT Participants who had a history of photosensitivity disorder Fitzpatrick's skin phototype V-VI
Sites / Locations
- University Hospital of ZurichRecruiting
Arms of the Study
Arm 1
Experimental
PDT group
PDT with 5% topical methyl aminolevulinate (MAL) before skin antisepsis