Role of Paclitaxel in Stricture Urethra
Stricture Urethra
About this trial
This is an interventional treatment trial for Stricture Urethra focused on measuring DVIU, Stricture, Paclitaxel
Eligibility Criteria
Inclusion Criteria: Anterior urethral stricture Short strictures (less than 2 cm) International Prostate Symptom Score less than 11 and maximum flow rate < 15 ml per second. No previous treatment for stricture disease Exclusion Criteria: Recurrent cases Prior pelvic radiation Associated other pathology or unresolved confounding etiologies (e.g. bladder neck contracture, neurogenic bladder, benign prostatic hyperplasia) were excluded.
Sites / Locations
- Mohamed Fawzy SalmanRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
DVIU with paclitaxel
DVIU
Cystourethroscopy will be performed using a 22 Fr rigid cystoscope to allow for ureteric catheter 3F/a wire to be passed through the stricture and into the urinary bladder. DVIU will be performed by cold-knife incisions at the 12-, 3-, and 9 o'clock positions through the full thickness of the fibrosis to healthier appearing tissue. A 23 Fr Wolf (Vernon Hills, IL) injection scope and a standard injection needle was used to inject 30 mg/5mL of paclitaxel vial, 1.5 mL will be injected along the length of each incision into healthier appearing tissue for a total of 5 mL.
Cystourethroscopy will be performed using a 22 Fr rigid cystoscope to allow for ureteric catheter 3F/a wire to be passed through the stricture and into the urinary bladder. DVIU will be performed by cold-knife incisions at the 12-, 3-, and 9 o'clock positions through the full thickness of the fibrosis to healthier appearing tissue.