Antibiotics Against Amyloid Angiopathy (BATMAN)

Inclusion Criteria: Age ≥18 years for D-CAA and age ≥55 years for sporadic-CAA Probable-CAA according to the Modified-Boston-Criteria or genetically proven D-CAA ≤ 2 ICH (occurrence of ICHs at least 1 year ago) and presence of ≥ 2 lobar microbleeds +/-cortical superficial siderosis Written informed consent Exclusion Criteria: Previous allergic reactions to minocycline Modified Rankin Score ≥3 Contraindications, such as: Contraindications for 7T MRI as determined by the 7Tesla safety committee. Examples of possible contra-indications are: claustrophobia, pacemakers and defibrillators, nerve stimulators, intracranial clips, intraorbital or intraocular metallic fragments, cochlear implants, ferromagnetic implants, hydrocephalus pump, intra-uterine device, permanent make-up, tattoos above the shoulders. In case of specific contra-indications for 7T a 3T will be made instead. - Specific contraindications for checkerboard fMRI: seizure within prior year, photosensitive epilepsy, noncorrectable visual impairment. - Contraindications for lumbar puncture: compression of the spinal cord, signs and symptoms of increased intracranial pressure, local infections of the skin at the puncture site, a coagulopathy or thrombocytopenia (<100). (Use of acetylsalicylic acid, NSAIDs, COX2 inhibitors or low-molecular-weight heparin are no contraindications for lumbar puncture.) Pregnancy/breast feeding Liver/renal failure Use of antibiotics <1 month SLE or other diseases known to generate inflammatory responses Previous/current/planned use of retinoids (since this is related to increasing risk of increased intracranial pressure) Current use of anaesthetics like methoxyflurane, agents inhibiting peristalsis, barbiturates, carbamazepine or fenytoïne