Feasibility Assessment of Cardiovascular Endurance Training for the Symptomatic Improvement of Irritable Bowel Syndrome Patients With a Sedentary and Non-active Lifestyle.

Inclusion Criteria: Patients aged 18 - 60 years; Fulfilling the ROME IV criteria for Irritable bowel syndrome (IBS); Moderate symptom severity as defined by a IBS-Symptom Severity Scale > 175; Sedentary lifestyle defined as SIT-Q-7D > 8h/day; Physically inactive defined as < 150min/week on the IPAQ score Exclusion Criteria: Cardiorespiratory disorder hampering participation in a program of physical exercise as evidenced by the sport + keuringsartsen (SKA) questionnaire. Clinical suspicion of an organic disorder different from IBS (patients can be included when this disorder had been excluded); Known inflammatory bowel disorder; Known intestinal motility disorder; Alcohol (defined as more than 14 U per week) or other substance abuse; Active psychiatric disorder; Known systemic or auto-immune disorder with implication for the GI system; Prior abdominal surgery (with the exception of appendectomy or cholecystectomy more than 6 months ago); Any prior diagnosis of cancer other than basocellular carcinoma; Current chemotherapy; History of gastro-enteritis in the past 8 weeks; Change in diet in the past 8 weeks; Dietary supplements unless taken at a stable dose for more than 8 weeks; Antibiotics, pre-, pro-, post-biotics or any combination during the past 8 weeks; Treatment with neuromodulators (one neuromodulator taken at a stable dose for more than 12 weeks is allowed); Treatment with spasmolytic agents, opioids, loperamide, gelatine tannate or mucoprotect-ants during the past 8 weeks.