microRNAs in the Diagnosis of Atherosclerotic Plaque Instability
Atherosclerosis of Artery
About this trial
This is an interventional prevention trial for Atherosclerosis of Artery focused on measuring unstable plaque, miRNA, trimethylamine N-oxide, atherosclerosis, carotid artery
Eligibility Criteria
Inclusion Criteria: Availability of written informed consent to participate in research work; Age from 18 to 85 years; Availability of data from a general blood test, blood lipid profile (total cholesterol, very low density lipoproteins, low density lipoproteins, high density lipoproteins, triglycerides); Absence of clinical signs of atherosclerosis of brachiocephalic arteries (no stroke, transient ischemic attack. On auscultation of the carotid arteries, there are no additional noises); Absence of signs of atherosclerosis of the brachiocephalic arteries according to ultrasound duplex scanning (USDS) and/or multispiral computed tomography (MSCT) angiography of the brachiocephalic arteries; Conducted outpatient visit at a research center with clinical and biochemical blood tests performed, ultrasound examination of arterial vessels and/or multispiral tomography of arterial vessels with contrast enhancement and/or hospitalization at a research center. Non-inclusion criteria: Chronic kidney disease stage 3b and above (glomerular filtration rate < 45 ml / min / 1.73 sq.m); The presence of severe somatic pathology (with the exception of atherosclerosis of the carotid arteries and conditions caused by it), reducing life expectancy to less than 6 months; Chronic somatic diseases in the acute stage; Weight less than 40kg and more than 125kg; Pregnancy. Exclusion Criteria 1. Refusal to continue participation in the study.
Sites / Locations
- I.M. Sechenov First Moscow State Medical University (Sechenov University)Recruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
atherosclerosis of the brachiocephalic arteries
No brachiocephalic atherosclerosis
The recruitment of patients will be carried out at the University Clinical Hospital No. 1 of the Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University). The study will include up to 50 people - the study group with atherosclerosis of the brachiocephalic arteries.
The recruitment of patients will be carried out at the University Clinical Hospital No. 1 of the Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University). Up to 30 people - the control group without brachiocephalic atherosclerosis.