Anemia Studies in CKD: Erythropoiesis Via a Novel PHI Daprodustat - Pediatric (ASCEND-P) (ASCEND-P)
Anaemia

About this trial
This is an interventional treatment trial for Anaemia focused on measuring Daprodustat, ASCEND-P, Anemia, Chronic kidney disease, Erythropoiesis stimulating agent, Dialysis, Non-dialysis, 214066, 212914
Eligibility Criteria
Inclusion Criteria: Participant must be 3 months to less than (<)18 years of age. Anemia associated with CKD stage 3, 4, 5 (not on dialysis) or who have dialysis-dependent CKD, defined as Hgb 7.0 to 11.0 g/dL (if not using erythropoiesis stimulating agents [ESAs]) or Hgb 9.5 to 12.0 g/dL if using ESAs. Written informed consent or assent as appropriate. Exclusion Criteria: Kidney transplant recipient with a functioning allograft. Scheduled for elective kidney transplantation within 3 months. Transferrin saturation (TSAT) < 20 percent (%), or Ferritin <25 nanogram (ng)/milliliter (mL). History of bone marrow aplasia or pure red cell aplasia. Active hemolysis. Other causes of anemia. Active gastrointestinal bleeding within the last 4 weeks. Active or previous malignancy within the last 2 years. Acute or chronic infection requiring antimicrobial therapy. History of significant thrombotic or thromboembolic events within the last 8 weeks. Heart failure (HF) New York Heart Association (NYHA) Class IV Uncontrolled hypertension. Alanine aminotransferase (ALT) >2× upper limit of normal (ULN), bilirubin >1.5× ULN (unless bilirubin is fractionated and direct bilirubin <35%), and cirrhosis or current unstable liver or biliary disease.
Sites / Locations
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Arms of the Study
Arm 1
Experimental
Daprodustat
All participants will receive daprodustat for up to 52 weeks.